2023
Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species
Pearce V, Groisman E, Townsend G. Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species. Gut Microbes 2023, 15: 2221484. PMID: 37358144, PMCID: PMC10294740, DOI: 10.1080/19490976.2023.2221484.Peer-Reviewed Original ResearchConceptsMaster regulatorMicrobial populationsOrthologous transcription factorsMammalian gut microbiotaMicrobial gene expressionHuman gut symbiontHuman gut BacteroidesDistinct microbial populationsIntestinal Bacteroides speciesGut symbiontsCarbohydrate utilizationMRNA leaderTranscription factorsHost dietGut BacteroidesNutrient availabilityGene expressionMolecular pathwaysUnknown mechanismDietary sugarsBacteroides speciesFuture therapeutic interventionsRegulatorSimple sugarsPathogenic outcomes
2020
A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor
Townsend GE, Han W, Schwalm ND, Hong X, Bencivenga-Barry NA, Goodman AL, Groisman EA. A Master Regulator of Bacteroides thetaiotaomicron Gut Colonization Controls Carbohydrate Utilization and an Alternative Protein Synthesis Factor. MBio 2020, 11: 10.1128/mbio.03221-19. PMID: 31992627, PMCID: PMC6989115, DOI: 10.1128/mbio.03221-19.Peer-Reviewed Original ResearchPutative translation factorProtein synthesis factorsTranslation factorsMammalian gutDietary fiber utilizationTranscriptional regulatorsBeneficial microbesSpecialized translation factorHundreds of genesMajor transcriptional regulatorGut colonizationCarbohydrate utilizationSynthesis factorsHuman gut microbiotaGlobal regulonGenetic repertoireTranscription factorsMaster regulatorDNA sequencesDerive nutrientsColonization defectUtilization of carbohydratesCellular metabolismComplex polysaccharidesGenes