Vibrio cholerae O1 experiences mild bottlenecks through the gastrointestinal tract in some but not all cholera patients
Lypaczewski P, Chac D, Dunmire C, Tandoc K, Chowdhury F, Khan A, Bhuiyan T, Harris J, LaRocque R, Calderwood S, Ryan E, Qadri F, Shapiro B, Weil A. Vibrio cholerae O1 experiences mild bottlenecks through the gastrointestinal tract in some but not all cholera patients. Microbiology Spectrum 2024, 12: e00785-24. PMID: 38916318, PMCID: PMC11302224, DOI: 10.1128/spectrum.00785-24.Peer-Reviewed Original ResearchGenetic diversityVibrio cholerae</i> O1Short-read dataLong-read sequencingDiarrheal disease choleraReduced genetic variationBacterial population sizeSingle-nucleotide variationsPangenome analysisGene presence/absencePilus operonPopulation bottlenecksDisease choleraMild bottleneckGene presenceGut colonizationGenetic variationAdaptive mutationsGenomeCholera patientsPopulation sizeGut resultsSites of active infectionGutStool samples