Antibiotic resistance and serotype distribution of Shigella strains in Bangladesh over the period of 2014-2022: evidence from a nationwide hospital-based surveillance for cholera and other diarrheal diseases.
Afrad M, Islam M, Begum Y, Saifullah M, Ahmmed F, Khan Z, Habib Z, Alam A, Shirin T, Bhuiyan T, Ryan E, Khan A, Qadri F. Antibiotic resistance and serotype distribution of Shigella strains in Bangladesh over the period of 2014-2022: evidence from a nationwide hospital-based surveillance for cholera and other diarrheal diseases. Microbiology Spectrum 2024, e0073924. PMID: 39540737, DOI: 10.1128/spectrum.00739-24.Peer-Reviewed Original ResearchAntimicrobial resistance patternsAntibiotic resistanceNalidixic acidResistance patternsAntibiotic susceptibility testingDisc diffusion methodStool specimensLevels of resistance to ciprofloxacinResistant to ciprofloxacinDiarrheal disease surveillanceQuinolone class of antibioticsClasses of antibioticsShigella strainsSerotype 2aShigella sonneiMonitoring of drug resistanceSusceptibility testingVaccine clinical trialsAcute watery diarrheaHospital-based surveillanceDiffusion methodIntermediate susceptibilityMultidrug resistanceSerotype distributionImproved hygieneDeterminants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function
Bernshtein B, Kelly M, Cizmeci D, Zhiteneva J, Macvicar R, Kamruzzaman M, Bhuiyan T, Chowdhury F, Khan A, Qadri F, Charles R, Xu P, Kováč P, Clarkson K, Kaminski R, Alter G, Ryan E. Determinants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function. The Lancet Microbe 2024, 5: 100889. PMID: 39116906, PMCID: PMC11488819, DOI: 10.1016/s2666-5247(24)00112-5.Peer-Reviewed Original ResearchFlexneri 2aShigella infectionO-specific polysaccharideS sonneiShigella flexneri 2aEndemic settingsAntibody responseInnate immune cell activationProduction of reactive oxygen speciesShigella sonneiFunctional antibody responsesNon-endemic populationCorrelates of protectionShigellaImmune cell activationShigella vaccineNon-endemic settingsReceptor binding profileReactive oxygen speciesSerum samplesAntibody-mediated activationHigh-burden settingsSonneiPredictive of protectionAntibody-mediated complement deposition