Determinants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function
Bernshtein B, Kelly M, Cizmeci D, Zhiteneva J, Macvicar R, Kamruzzaman M, Bhuiyan T, Chowdhury F, Khan A, Qadri F, Charles R, Xu P, Kováč P, Clarkson K, Kaminski R, Alter G, Ryan E. Determinants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function. The Lancet Microbe 2024, 5: 100889. PMID: 39116906, PMCID: PMC11488819, DOI: 10.1016/s2666-5247(24)00112-5.Peer-Reviewed Original ResearchFlexneri 2aShigella infectionO-specific polysaccharideS sonneiShigella flexneri 2aEndemic settingsAntibody responseInnate immune cell activationProduction of reactive oxygen speciesShigella sonneiFunctional antibody responsesNon-endemic populationCorrelates of protectionShigellaImmune cell activationShigella vaccineNon-endemic settingsReceptor binding profileReactive oxygen speciesSerum samplesAntibody-mediated activationHigh-burden settingsSonneiPredictive of protectionAntibody-mediated complement deposition