1989
Insulin resistance in uremia: An in vivo and in vitro study
Stein P, Hunt W, Johnson C, DeFronzo R, Smith J. Insulin resistance in uremia: An in vivo and in vitro study. Metabolism 1989, 38: 562-567. PMID: 2657327, DOI: 10.1016/0026-0495(89)90217-5.Peer-Reviewed Original ResearchConceptsUremic ratsAbility of insulinInsulin resistanceSoleus muscleTotal body glucose disposalEuglycemic insulin clamp techniqueInsulin clamp techniqueUremic rat modelHepatic glucose productionPair-fed controlsChronic uremiaGlucose disposalRat modelGlucose metabolismClamp techniqueGlucose productionMetabolic defectsInsulinRatsUremiaGlycogen synthesisGlucose oxidationMuscleVivoOxidative pathway
1985
Improved Insulin Sensitivity in Patients with Type I Diabetes Mellitus After CSII
Simonson D, Tamborlane W, Sherwin R, Smith J, DeFronzo R, Group T. Improved Insulin Sensitivity in Patients with Type I Diabetes Mellitus After CSII. Diabetes 1985, 34: 80-86. PMID: 3894130, DOI: 10.2337/diab.34.3.s80.Peer-Reviewed Original ResearchConceptsContinuous subcutaneous insulin infusionGlucose metabolismDiabetic patientsControl subjectsTissue sensitivityAge-matched control subjectsEuglycemic insulin clamp techniqueInsulin-mediated glucose utilizationInsulin clamp techniqueSubcutaneous insulin infusionPlasma glucose concentrationHepatic glucose productionInsulin-stimulated glucose uptakeType IIDDM patientsGlycemic controlInsulin infusionInsulin sensitivityImpaired responseInsulin administrationPeripheral tissuesPatientsClamp techniqueGlucose utilizationMetabolic correction