Insulin resistance in uremia: An in vivo and in vitro study
Stein P, Hunt W, Johnson C, DeFronzo R, Smith J. Insulin resistance in uremia: An in vivo and in vitro study. Metabolism 1989, 38: 562-567. PMID: 2657327, DOI: 10.1016/0026-0495(89)90217-5.Peer-Reviewed Original ResearchConceptsUremic ratsAbility of insulinInsulin resistanceSoleus muscleTotal body glucose disposalEuglycemic insulin clamp techniqueInsulin clamp techniqueUremic rat modelHepatic glucose productionPair-fed controlsChronic uremiaGlucose disposalRat modelGlucose metabolismClamp techniqueGlucose productionMetabolic defectsInsulinRatsUremiaGlycogen synthesisGlucose oxidationMuscleVivoOxidative pathway