2017
Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death
Anand S, Rollakanti KR, Brankov N, Brash DE, Hasan T, Maytin EV. Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death. Molecular Cancer Therapeutics 2017, 16: 1092-1101. PMID: 28336806, PMCID: PMC5497500, DOI: 10.1158/1535-7163.mct-16-0608.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiosynthetic PathwaysCarcinoma, Squamous CellCell DeathCell Line, TumorCell ProliferationCombined Modality TherapyDisease Models, AnimalFluorouracilGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHemeHumansMicePhotochemotherapyProtoporphyrinsTumor Suppressor Protein p53Xenograft Model Antitumor AssaysConceptsSquamous cell carcinomaActinic keratosesPhotodynamic therapyP53-null tumorsNew therapeutic approachesMol Cancer TherCell deathCell carcinomaTherapeutic responsePpIX levelsTherapeutic approachesMouse modelSkin cancerSCC precursorsHeme synthesis pathwayTumorsKeratosesDeathP53PDT efficacyInductionPretreatmentNeoadjuvantCombination approachSurgery
2003
Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice
Wikonkal NM, Remenyik E, Knezevic D, Zhang W, Liu M, Zhao H, Berton TR, Johnson DG, Brash DE. Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice. Nature Cell Biology 2003, 5: 655-660. PMID: 12833065, DOI: 10.1038/ncb1001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell Cycle ProteinsCell SurvivalCell Transformation, NeoplasticCells, CulturedDNA DamageDNA-Binding ProteinsE2F Transcription FactorsE2F1 Transcription FactorFemaleFibroblastsGene Expression Regulation, NeoplasticGenes, SuppressorKeratinocytesMaleMiceMice, KnockoutMutationSex RatioSkin NeoplasmsTranscription FactorsTumor Suppressor Protein p53Ultraviolet RaysConceptsUVB-induced apoptosisEarly-onset tumorsDouble knockout miceTrp53-deficient miceKnockout miceCancer sensitivityUVB exposureGenetic abnormalitiesMiceKeratinocyte apoptosisProtective mechanismApoptosis defectsApoptosis resistanceApoptosisDouble knockoutApoptosis pathwayE2F1 transcription factorE2F1 functionsPrimary fibroblastsE2F1Trp53S phase
1999
Induction of cyclin-dependent kinase inhibitors and G1 prolongation by the chemopreventive agent N-acetylcysteine
Liu M, Wikonkal N, Brash D. Induction of cyclin-dependent kinase inhibitors and G1 prolongation by the chemopreventive agent N-acetylcysteine. Carcinogenesis 1999, 20: 1869-1872. PMID: 10469636, DOI: 10.1093/carcin/20.9.1869.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsAnticarcinogenic AgentsAntioxidantsCell CycleCell LineChromansCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21CyclinsFibroblastsFree Radical ScavengersG1 PhaseGene Expression RegulationGene Expression Regulation, NeoplasticGenes, p16GlutathioneHumansKeratinocytesMiceModels, BiologicalNeoplasm ProteinsPapillomaSkin NeoplasmsTumor Cells, CulturedTumor Suppressor Protein p53ConceptsCyclin-dependent kinase inhibitorNovel molecular basisCell cycle transitionKinase inhibitorsDNA replicationDNA repairCellular differentiationMolecular basisG1 prolongationGene expressionAntioxidant N-acetylcysteineN-acetylcysteineIntracellular glutathione levelsArrestAgent N-acetylcysteineInductionInhibitorsGlutathione levelsCyclinChemopreventive agentsChemopreventive activityDifferentiationUsual mechanismP53Replication
1998
Antioxidant action via p53-mediated apoptosis.
Liu M, Pelling JC, Ju J, Chu E, Brash DE. Antioxidant action via p53-mediated apoptosis. Cancer Research 1998, 58: 1723-9. PMID: 9563490.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsAntioxidantsApoptosisBlotting, NorthernBlotting, WesternButhionine SulfoximineCells, CulturedDimercaprolDose-Response Relationship, DrugGene Expression Regulation, NeoplasticGlutathioneMiceOxidation-ReductionPyrrolidonecarboxylic AcidSulfhydryl CompoundsThiazolesThiazolidinesTumor Cells, CulturedTumor Suppressor Protein p53Vitamin EConceptsP53 inductionCellular redox potentialP53-dependent apoptosisNormal cellsP53-mediated apoptosisTumor suppressor geneP53 mRNA translationCellular thiol levelsMRNA translationRedox sensorProtein stabilitySuppressor geneP53 tumor suppressor geneNontoxic antioxidantsApoptosisCell linesSulfur-containing antioxidantsBiological effectsPrimary culturesElevated p53 expressionCellsInductionN-acetylcysteineGlutathione levelsRedox potential