2001
Gα16 Couples Chemoattractant Receptors to NF-κB Activation
Yang M, Sang H, Rahman A, Wu D, Malik A, Ye R. Gα16 Couples Chemoattractant Receptors to NF-κB Activation. The Journal Of Immunology 2001, 166: 6885-6892. PMID: 11359849, DOI: 10.4049/jimmunol.166.11.6885.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusAmino Acid SubstitutionCell NucleusEnzyme ActivationGenes, ReporterGlutamineGTP-Binding Protein alpha Subunits, Gq-G11HeLa CellsHeterotrimeric GTP-Binding ProteinsHumansIsoenzymesLeucineLuciferasesNF-kappa BPhospholipase C betaReceptors, ChemokineReceptors, Formyl PeptideReceptors, ImmunologicReceptors, PeptideSignal TransductionTrans-ActivatorsTransfectionType C PhospholipasesConceptsNF-kappaB activationFormyl peptide receptorChemoattractant receptorsPeptide receptorCXC chemokine receptor 2NF-kappaB.Chemokine receptor 2Regulatory protein alpha subunitNF-κB activationLuciferase activityProtein kinase CKappaB-luciferase activityPhosphorylation of IkappaBalphaPhospholipase C-beta activityC3a receptorReceptor 2Seven-membrane-spanning receptorsAgonist stimulationConventional PKC isoformsPharmacological inhibitorsLuciferase reporterReceptorsHemopoietic cellsProtein alpha subunitsCell model system
2000
Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathway
Wong H, Mao J, Nguyen J, Srinivas S, Zhang W, Liu B, Li L, Wu D, Zheng J. Structural basis of the recognition of the Dishevelled DEP domain in the Wnt signaling pathway. Nature Structural & Molecular Biology 2000, 7: 1178-1184. PMID: 11101902, PMCID: PMC4381838, DOI: 10.1038/82047.Peer-Reviewed Original Research3T3 CellsAdaptor Proteins, Signal TransducingAmino Acid SequenceAmino Acid SubstitutionAnimalsBinding SitesCell MembraneDishevelled ProteinsDNA-Binding ProteinsLymphoid Enhancer-Binding Factor 1Membrane ProteinsMiceModels, MolecularMolecular Sequence DataMutationNuclear Magnetic Resonance, BiomolecularPhosphoproteinsProtein BindingProtein FoldingProtein Structure, SecondaryProtein Structure, TertiaryProto-Oncogene ProteinsSequence AlignmentSignal TransductionStatic ElectricityStructure-Activity RelationshipSubstrate SpecificityTranscription FactorsTransfectionWnt ProteinsZebrafish Proteins