2024
Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis
Ibrahim K, Iturmendi-Sabater I, Vasishth M, Barron D, Guardavaccaro M, Funaro M, Holmes A, McCarthy G, Eickhoff S, Sukhodolsky D. Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis. Schizophrenia Research 2024, 264: 298-313. PMID: 38215566, PMCID: PMC10922721, DOI: 10.1016/j.schres.2023.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderBrainBrain MappingFixation, OcularHumansLikelihood FunctionsMagnetic Resonance ImagingSchizophreniaConceptsRight inferior frontal gyrusAutism spectrum disorderInferior frontal gyrusEye gaze processingActivation likelihood estimationRight fusiform gyrusGaze processingFrontal gyrusFusiform gyrusFrontotemporal circuitryFunctional decodingSpectrum disorderActivation likelihood estimation meta-analysisMeta-analytic connectivity modelingMeta-analytic connectivityNeural circuit disruptionsTransdiagnostic biomarkerEmotional processingLeft amygdalaNeurobiological dysfunctionSocial cognitionEmotion perceptionNeural mechanismsSchizophreniaSpatial cognition
2021
What are we optimizing for in autism screening? Examination of algorithmic changes in the M‐CHAT
Schjølberg S, Shic F, Volkmar FR, Nordahl‐Hansen A, Stenberg N, Torske T, Larsen K, Riley K, Sukhodolsky DG, Leckman JF, Chawarska K, Øien RA. What are we optimizing for in autism screening? Examination of algorithmic changes in the M‐CHAT. Autism Research 2021, 15: 296-304. PMID: 34837355, PMCID: PMC8821132, DOI: 10.1002/aur.2643.Peer-Reviewed Original ResearchAutism Spectrum DisorderAutistic DisorderChecklistChildCohort StudiesFemaleHumansInfantMass ScreeningMothersConducting CBT for Anxiety in Children with Autism Spectrum Disorder During COVID-19 Pandemic
Kalvin CB, Jordan RP, Rowley SN, Weis A, Wood KS, Wood JJ, Ibrahim K, Sukhodolsky DG. Conducting CBT for Anxiety in Children with Autism Spectrum Disorder During COVID-19 Pandemic. Journal Of Autism And Developmental Disorders 2021, 51: 4239-4247. PMID: 33385281, PMCID: PMC7775616, DOI: 10.1007/s10803-020-04845-1.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyAutism Spectrum DisorderChildCognitive Behavioral TherapyCOVID-19HumansPandemicsSARS-CoV-2TelemedicineTreatment OutcomeConceptsCognitive behavioral therapyAutism spectrum disorderSpectrum disorderEngagement of childrenChild anxietyExposure exercisesTreatment fidelityCOVID-19 pandemicAnxietyTelehealth deliveryTreatment targetsChildrenRemote deliveryDisordersTreatment deliveryResearch protocolParentsQuarantine restrictionsEngagementPandemicNew reality
2020
Parent Emotion Socialization in Children with Autism Spectrum Disorder and Co-Occurring Anxiety
Jordan R, Kalvin CB, Ibrahim K, Sukhodolsky DG. Parent Emotion Socialization in Children with Autism Spectrum Disorder and Co-Occurring Anxiety. Research On Child And Adolescent Psychopathology 2020, 49: 125-137. PMID: 33442839, PMCID: PMC7809195, DOI: 10.1007/s10802-020-00731-7.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyAnxiety DisordersAutism Spectrum DisorderChildEmotionsHumansParent-Child RelationsParentsSocializationConceptsAutism spectrum disorderChildren’s emotional experiencesParent emotion socializationEmotion socialization practicesNegative Emotions ScaleEmotional experienceEmotion socializationTD childrenSpectrum disorderSocialization practicesGreater anxietyParent emotion socialization practicesChildren's Negative Emotions ScaleSocialization approachEmotion-focused responsesASD symptom severityCo-occurring anxietyFamilies of childrenParents of childrenParent socializationEmotions ScalePsychiatric disordersChild anxietyFluent childrenLower anxietyAssessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index
Kalvin CB, Gladstone TR, Jordan R, Rowley S, Marsh CL, Ibrahim K, Sukhodolsky DG. Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index. Journal Of Autism And Developmental Disorders 2020, 51: 1496-1507. PMID: 32734421, PMCID: PMC7855357, DOI: 10.1007/s10803-020-04627-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffective SymptomsAnxietyAutism Spectrum DisorderChildCross-Sectional StudiesFemaleHumansIrritable MoodMaleMood DisordersParentsSurveys and Questionnaires
2019
Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder
Kalvin CB, Marsh CL, Ibrahim K, Gladstone TR, Woodward D, Grantz H, Ventola P, Sukhodolsky DG. Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder. Autism Research 2019, 13: 93-103. PMID: 31643143, PMCID: PMC7062240, DOI: 10.1002/aur.2220.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersAutism Spectrum DisorderChildFemaleHumansMaleParentsSelf ReportAnxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior
Sukhodolsky DG, Lecavalier L, Johnson C, Smith T, Swiezy N, Bearss K, Kalvin CB, Scahill L. Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior. Autism 2019, 24: 400-410. PMID: 31390873, PMCID: PMC6982590, DOI: 10.1177/1362361319866561.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyAnxiety DisordersAttention Deficit and Disruptive Behavior DisordersAutism Spectrum DisorderChildChild, PreschoolFemaleHumansMaleParentsProblem BehaviorConceptsAutism spectrum disorderSpectrum disorderAnxiety symptomsDisruptive behaviorParent-completed rating scaleOppositional defiant behaviorYoung childrenEarly Childhood InventorySchool-aged childrenAnxiety severity scoresChild psychiatric symptomsParent trainingDefiant behaviorOppositional behaviorBehavioral problemsSocial withdrawalPreschool childrenAnxietyIQSocial disabilityPsychiatric symptomsChildrenRating ScalePercent of childrenSignificant symptomsAltered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality‐Controlled Diffusion Tensor Imaging Study
Lei J, Lecarie E, Jurayj J, Boland S, Sukhodolsky DG, Ventola P, Pelphrey KA, Jou RJ. Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality‐Controlled Diffusion Tensor Imaging Study. Autism Research 2019, 12: 1472-1483. PMID: 31347307, PMCID: PMC6851962, DOI: 10.1002/aur.2180.Peer-Reviewed Original ResearchAnger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder
Ibrahim K, Kalvin C, Marsh CL, Anzano A, Gorynova L, Cimino K, Sukhodolsky DG. Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3656-3668. PMID: 31144231, PMCID: PMC7035789, DOI: 10.1007/s10803-019-04085-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAngerAttention Deficit and Disruptive Behavior DisordersAutism Spectrum DisorderChildFemaleHumansMaleRumination, CognitiveReduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior
Ibrahim K, Eilbott JA, Ventola P, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 1031-1041. PMID: 30979647, PMCID: PMC7173634, DOI: 10.1016/j.bpsc.2019.01.009.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCallous-unemotional traitsAmygdala-vlPFC connectivityDisruptive behaviorAmygdala reactivityNeural mechanismsSpectrum disorderAmygdala-prefrontal functional connectivityEmotion perception taskFunctional magnetic resonance imagingVentrolateral prefrontal cortexUnderlying neural mechanismsDisruptive behavior disordersTask-specific changesRisk of aggressionEmotion dysregulationFearful facesCalm facesPerception taskFear processingAmygdala activityPsychophysiological interactionAmygdala connectivityExternalizing behaviorsAmygdala hyperactivity
2018
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder
Lewis AS, van Schalkwyk GI, Lopez MO, Volkmar FR, Picciotto MR, Sukhodolsky DG. An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2018, 48: 2748-2757. PMID: 29536216, PMCID: PMC6394231, DOI: 10.1007/s10803-018-3536-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAggressionAutism Spectrum DisorderDouble-Blind MethodFemaleHumansIrritable MoodMaleMiddle AgedNicotineNicotinic AgonistsTransdermal PatchConceptsAutism spectrum disorderSpectrum disorderTransdermal nicotineDouble-blind crossover trialAggressive behaviorPreliminary efficacyAggressive symptomsSleep ratingsAggressionSubscale changesNicotinic acetylcholine receptorsNAChR agonistsPrimary outcomeNicotine treatmentCrossover trialExploratory trialΑ7 nAChRsAcetylcholine receptorsNicotineAdultsDisordersPlaceboNAChRsFurther investigationTrials
2016
Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder
Lecavalier L, Smith T, Johnson C, Bearss K, Swiezy N, Aman MG, Sukhodolsky DG, Deng Y, Dziura J, Scahill L. Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder. Research On Child And Adolescent Psychopathology 2016, 45: 1235-1245. PMID: 27917460, PMCID: PMC5459681, DOI: 10.1007/s10802-016-0233-x.Peer-Reviewed Original ResearchConceptsHome Situations QuestionnaireAutism spectrum disorderParent education programAttention deficit hyperactivity disorderParent trainingAberrant Behavior Checklist-Irritability subscaleSpectrum disorderClinical Global Impressions-Improvement scaleDisruptive behaviorOppositional defiant disorder symptomsASD symptom severityLow anxiety groupDeficit hyperactivity disorderYoung childrenADHD groupASD severityHyperactivity disorderAnxiety groupDisorder symptomsPotential moderatorsSituations QuestionnaireNoncompliant behaviorAge 3ModeratorSymptom severityBrain responses to biological motion predict treatment outcome in young children with autism
Yang D, Pelphrey KA, Sukhodolsky DG, Crowley MJ, Dayan E, Dvornek NC, Venkataraman A, Duncan J, Staib L, Ventola P. Brain responses to biological motion predict treatment outcome in young children with autism. Translational Psychiatry 2016, 6: e948-e948. PMID: 27845779, PMCID: PMC5314125, DOI: 10.1038/tp.2016.213.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderYoung childrenSocial information processingMultivariate pattern analysisMotivation/rewardBiological motionCore deficitComplex neurodevelopmental disorderBrain responsesResponse treatmentSpectrum disorderNeurobiological markersNeural predictorsInformation processingBehavioral interventionsIndividual childrenNeurodevelopmental disordersCurrent findingsNeural circuitsBehavioral deficitsEarly childhoodChildrenUnsuccessful interventionsNeurobiomarkersPattern analysisBrief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment
Ventola PE, Yang D, Abdullahi SM, Paisley CA, Braconnier ML, Sukhodolsky DG. Brief Report: Reduced Restricted and Repetitive Behaviors after Pivotal Response Treatment. Journal Of Autism And Developmental Disorders 2016, 46: 2813-2820. PMID: 27230762, PMCID: PMC4939123, DOI: 10.1007/s10803-016-2813-6.Peer-Reviewed Original ResearchEffect of Parent Training on Adaptive Behavior in Children With Autism Spectrum Disorder and Disruptive Behavior: Results of a Randomized Trial
Scahill L, Bearss K, Lecavalier L, Smith T, Swiezy N, Aman MG, Sukhodolsky DG, McCracken C, Minshawi N, Turner K, Levato L, Saulnier C, Dziura J, Johnson C. Effect of Parent Training on Adaptive Behavior in Children With Autism Spectrum Disorder and Disruptive Behavior: Results of a Randomized Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 602-609.e3. PMID: 27343887, DOI: 10.1016/j.jaac.2016.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAutism Spectrum DisorderChildChild, PreschoolEducation, NonprofessionalFamily TherapyFemaleHumansMaleOutcome Assessment, Health CareParentsProblem BehaviorConceptsAutism spectrum disorderParent training groupParent trainingDaily living skillsDisruptive behaviorAdaptive behaviorParent educationSpectrum disorderLiving skillsVineland Adaptive Behavior Scales-IIHigh-functioning childrenTraining groupGreater behavioral problemsYoung childrenIntellectual disabilityBehavior management strategiesAdaptive functioningSocialization domainsTelephone boosterBehavioral problemsScale IIDaily livingCommunication domainCore sessionsDaily living domains
2015
Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials
Scahill L, Sukhodolsky DG, Anderberg E, Dimitropoulos A, Dziura J, Aman MG, McCracken J, Tierney E, Hallett V, Katz K, Vitiello B, McDougle C. Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials. Autism 2015, 20: 145-152. PMID: 25882391, DOI: 10.1177/1362361315574889.Peer-Reviewed Original Research
2014
Heterogeneity of neural mechanisms of response to pivotal response treatment
Ventola P, Yang DY, Friedman HE, Oosting D, Wolf J, Sukhodolsky DG, Pelphrey KA. Heterogeneity of neural mechanisms of response to pivotal response treatment. Brain Imaging And Behavior 2014, 9: 74-88. PMID: 25370452, PMCID: PMC4993028, DOI: 10.1007/s11682-014-9331-y.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderBehavior TherapyBrain MappingChildChild BehaviorChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleNerve NetTreatment OutcomeConceptsPivotal Response TreatmentPosterior superior temporal sulcusFunctional magnetic resonance imagingAutism spectrum disorderNeural responsesResponse treatmentRight posterior superior temporal sulcusBiological motion perception taskDifferential neural responsesMotion perception taskSuperior temporal sulcusPerception taskTD childrenTemporal sulcusSocial perceptionBrain responsesNeural mechanismsSpectrum disorderSocial communicationNeural vulnerabilityNeural characteristicsNeural systemsVentral striatumReward systemSubcortical regions