2017
Extended-Release Guanfacine Does Not Show a Large Effect on Tic Severity in Children with Chronic Tic Disorders
Murphy TK, Fernandez TV, Coffey BJ, Rahman O, Gavaletz A, Hanks CE, Tillberg CS, Gomez LI, Sukhodolsky DG, Katsovich L, Scahill L. Extended-Release Guanfacine Does Not Show a Large Effect on Tic Severity in Children with Chronic Tic Disorders. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 762-770. PMID: 28723227, DOI: 10.1089/cap.2017.0024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-2 Receptor AgonistsChildDouble-Blind MethodFemaleGuanfacineHumansMalePsychiatric Status Rating ScalesSeverity of Illness IndexTic DisordersTreatment OutcomeConceptsExtended-release guanfacineLack of efficacyChronic tic disorderGuanfacine groupPlacebo groupYGTSS total scoreAdverse eventsTotal scoreTic disordersYale Global Tic Severity Scale total scoreClinical Global Impressions-Improvement scaleCommon adverse eventsPlacebo-controlled trialKey secondary outcomesPrimary outcome measureLarger efficacy trialScale total scoreDry mouthSecondary outcomesPreliminary efficacyWeek 8Efficacy trialsOutcome measuresTic severityTourette's disorder
2015
Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials
Scahill L, Sukhodolsky DG, Anderberg E, Dimitropoulos A, Dziura J, Aman MG, McCracken J, Tierney E, Hallett V, Katz K, Vitiello B, McDougle C. Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials. Autism 2015, 20: 145-152. PMID: 25882391, DOI: 10.1177/1362361315574889.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntipsychotic AgentsAutism Spectrum DisorderChildChild, PreschoolDouble-Blind MethodFemaleHealth EducationHumansMaleObsessive-Compulsive DisorderParentsPsychiatric Status Rating ScalesRisperidone
2014
Examination of Aggression and Self-injury in Children with Autism Spectrum Disorders and Serious Behavioral Problems
Carroll D, Hallett V, McDougle CJ, Aman MG, McCracken JT, Tierney E, Arnold LE, Sukhodolsky DG, Lecavalier L, Handen BL, Swiezy N, Johnson C, Bearss K, Vitiello B, Scahill L. Examination of Aggression and Self-injury in Children with Autism Spectrum Disorders and Serious Behavioral Problems. Child And Adolescent Psychiatric Clinics Of North America 2014, 23: 57-72. PMID: 24231167, PMCID: PMC4212264, DOI: 10.1016/j.chc.2013.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAnalysis of VarianceAntipsychotic AgentsChildChild Development Disorders, PervasiveChild, PreschoolChi-Square DistributionDouble-Blind MethodFemaleHumansIntelligence TestsMaleOutcome Assessment, Health CarePsychiatric Status Rating ScalesRandomized Controlled Trials as TopicRisperidoneSelf-Injurious BehaviorSeverity of Illness IndexConceptsAutism spectrum disorderSubtypes of aggressionSelf-injurious behaviorSpectrum disorderUnderstanding of aggressionSerious behavioral problemsParent interviewsBehavioral problemsSelf-InjuryAggressionStudy findingsChildrenRisperidone trialsChildren 2DisordersIndividualized treatmentPositive responseSubtypesFurther studiesBiological mechanismsHigh rateInterviewsFindingsNarrativesBehavior
2012
Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome
Wilhelm S, Peterson AL, Piacentini J, Woods DW, Deckersbach T, Sukhodolsky DG, Chang S, Liu H, Dziura J, Walkup JT, Scahill L. Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome. JAMA Psychiatry 2012, 69: 795-803. PMID: 22868933, PMCID: PMC3772729, DOI: 10.1001/archgenpsychiatry.2011.1528.Peer-Reviewed Original ResearchMeSH KeywordsAdultBehavior TherapyFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesSelf ReportSeverity of Illness IndexTicsTourette SyndromeTreatment OutcomeConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionTic Severity ScaleTourette syndromeBehavior therapySeverity ScaleBehavioral interventionsOutpatient research clinicTotal tic scoreLeast moderate severityChronic tic disorderGreater mean decreaseMonthly booster sessionsAdult patientsSupportive treatmentModerate severityTic scoreTic disordersPositive respondersResearch clinicBooster sessionsMean decreasePosttreatment evaluationPatients
2011
Poor fine‐motor and visuospatial skills predict persistence of pediatric‐onset obsessive‐compulsive disorder into adulthood
Bloch MH, Sukhodolsky DG, Dombrowski PA, Panza KE, Craiglow BG, Landeros‐Weisenberger A, Leckman JF, Peterson BS, Schultz RT. Poor fine‐motor and visuospatial skills predict persistence of pediatric‐onset obsessive‐compulsive disorder into adulthood. Journal Of Child Psychology And Psychiatry 2011, 52: 974-983. PMID: 21244423, PMCID: PMC3625937, DOI: 10.1111/j.1469-7610.2010.02366.x.Peer-Reviewed Original ResearchConceptsLong-term outcomesVisual-motor integrationPoor long-term outcomesCox proportional hazards modelBeery-Buktenica TestPediatric-onset obsessive-compulsive disorderFine motor skill deficitsPurdue pegboard taskCourse of symptomsProportional hazards modelPurdue Pegboard TestComorbid tic disordersAge of onsetVisuospatial skillsFuture longitudinal studiesOCD symptomsFine motor skillsCases remitNonverbal memory performanceObsessive-compulsive disorderNeuropsychiatric deficitsTic disordersMAIN OUTCOMEPegboard TestNeuropsychological testing
2008
Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders
Scahill L, Aman MG, McDougle CJ, Arnold LE, McCracken JT, Handen B, Johnson C, Dziura J, Butter E, Sukhodolsky D, Swiezy N, Mulick J, Stigler K, Bearss K, Ritz L, Wagner A, Vitiello B. Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders. Journal Of Autism And Developmental Disorders 2008, 39: 720-729. PMID: 19096921, PMCID: PMC4807607, DOI: 10.1007/s10803-008-0675-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionBehavior TherapyChildChild Development Disorders, PervasiveCombined Modality TherapyDopamine AntagonistsFemaleHumansMaleOutpatientsParent-Child RelationsParentsPatient CompliancePersonality AssessmentPsychiatric Status Rating ScalesRisperidoneSelf-Injurious BehaviorTreatment OutcomeConceptsParent trainingAdaptive functioningPervasive developmental disorderMeasures of noncomplianceBehavioral interventionsSymptom reductionDevelopmental disordersTraining targetClinical treatment targetsTrial design challengesTreatment targetsFunctioningTrainingFunctional improvementLow doseTreatment groupsMedicationsClinical practiceTantrumsAggressionBeneficial effectsIrritabilityChildrenNoncomplianceDisorders
2006
Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents
Stewart SE, Rosario MC, Brown TA, Carter AS, Leckman JF, Sukhodolsky D, Katsovitch L, King R, Geller D, Pauls DL. Principal Components Analysis of Obsessive–Compulsive Disorder Symptoms in Children and Adolescents. Biological Psychiatry 2006, 61: 285-291. PMID: 17161383, DOI: 10.1016/j.biopsych.2006.08.040.Peer-Reviewed Original ResearchRandomized Trial of Parent Management Training in Children With Tic Disorders and Disruptive Behavior
Scahill L, Sukhodolsky DG, Bearss K, Findley D, Hamrin V, Carroll DH, Rains AL. Randomized Trial of Parent Management Training in Children With Tic Disorders and Disruptive Behavior. Journal Of Child Neurology 2006, 21: 650-656. PMID: 16970865, DOI: 10.1177/08830738060210080201.Peer-Reviewed Original ResearchConceptsTic disordersParent management trainingUsual groupClinical Global ImpressionShort-term efficacyRating Scale scoresShort-term improvementDisruptive behaviorRandomized trialsStable medicationBehavior rating scale scoresGlobal ImpressionParent management training programsClinical trialsImprovement ScaleScale scoreStructured parent training programTraining programTreatment assignmentParent training programTraining groupDisruptive behavior problemsDisordersClinical samplesSevere levels
2005
Adaptive, Emotional, and Family Functioning of Children With Obsessive-Compulsive Disorder and Comorbid Attention Deficit Hyperactivity Disorder
Sukhodolsky DG, do Rosario-Campos MC, Scahill L, Katsovich L, Pauls DL, Peterson BS, King RA, Lombroso PJ, Findley DB, Leckman JF. Adaptive, Emotional, and Family Functioning of Children With Obsessive-Compulsive Disorder and Comorbid Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2005, 162: 1125-1132. PMID: 15930061, PMCID: PMC2291297, DOI: 10.1176/appi.ajp.162.6.1125.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAttention Deficit Disorder with HyperactivityChildComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersEmotionsFamily HealthFemaleHealth StatusHumansMaleObsessive-Compulsive DisorderPersonality InventoryPsychiatric Status Rating ScalesSurveys and QuestionnairesConceptsAttention deficit hyperactivity disorderObsessive-compulsive disorderComorbid attention deficit hyperactivity disorderDiagnosis of OCDDeficit hyperactivity disorderFamily functioningEmotional adjustmentHyperactivity disorderVineland Adaptive Behavior ScalesSelf-reported anxietyDaily living skillsAdaptive Behavior ScalesAdolescents ages 7Self-reported depressionBest-estimate DSM-IV diagnosesGroup of childrenAdaptive functioningLevel of impairmentChild functioningParent ratingsComparison childrenEmotional functioningComprehensive batteryLiving skillsDSM-IV diagnosis
1997
The association between adaptive and cognitive deficits in geriatric chronic schizophrenic patients
Harvey P, Sukhodolsky D, Parrella M, White L, Davidson M. The association between adaptive and cognitive deficits in geriatric chronic schizophrenic patients. Schizophrenia Research 1997, 27: 211-218. PMID: 9416650, DOI: 10.1016/s0920-9964(97)00068-6.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAge of OnsetAgedAged, 80 and overCognition DisordersComorbidityDisruptive, Impulse Control, and Conduct DisordersFemaleGeriatric AssessmentHumansMaleNeuropsychological TestsPsychiatric Status Rating ScalesPsychological TestsSchizophreniaSchizophrenic PsychologySelf CareSeverity of Illness IndexSocial AdjustmentConceptsUndercontrolled behaviorCognitive impairmentSocial skills deficitsChronic schizophreniaCognitive measuresCognitive batteryAdaptive functioningSkill deficitsCognitive deficitsAdaptive functionMagnitude of correlationsNegative symptomsStructured scaleDeficitsImpairmentChronic schizophrenic patientsSchizophrenic patientsSchizophreniaCertain aspectsFunctioningBehavior