2009
Medication and Parent Training in Children With Pervasive Developmental Disorders and Serious Behavior Problems: Results From a Randomized Clinical Trial
Aman MG, Mcdougle CJ, Scahill L, Handen B, Arnold LE, Johnson C, Stigler KA, Bearss K, Butter E, Swiezy NB, Sukhodolsky DD, Ramadan Y, Pozdol SL, Nikolov R, Lecavalier L, Kohn AE, Koenig K, Hollway JA, Korzekwa P, Gavaletz A, Mulick JA, Hall KL, Dziura J, Ritz L, Trollinger S, Yu S, Vitiello B, Wagner A, Network F. Medication and Parent Training in Children With Pervasive Developmental Disorders and Serious Behavior Problems: Results From a Randomized Clinical Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 1143-1154. PMID: 19858761, PMCID: PMC3142923, DOI: 10.1097/chi.0b013e3181bfd669.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderClinical trialsClinical Global Impressions-Improvement scoreAberrant Behavior Checklist IrritabilityParallel-group clinical trialParent trainingBehavioral problemsDevelopmental disordersRisperidone doseRisperidone monotherapyHyperactivity/noncompliance subscaleSevere behavioral problemsCOMB groupPT sessionsQuestionnaire scoresHSQ scoresMedicationsGreater reductionChildrenPrimary measureRisperidoneSignificant reductionStereotypic behaviorScoresDose
2008
Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders
Scahill L, Aman MG, McDougle CJ, Arnold LE, McCracken JT, Handen B, Johnson C, Dziura J, Butter E, Sukhodolsky D, Swiezy N, Mulick J, Stigler K, Bearss K, Ritz L, Wagner A, Vitiello B. Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders. Journal Of Autism And Developmental Disorders 2008, 39: 720-729. PMID: 19096921, PMCID: PMC4807607, DOI: 10.1007/s10803-008-0675-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionBehavior TherapyChildChild Development Disorders, PervasiveCombined Modality TherapyDopamine AntagonistsFemaleHumansMaleOutpatientsParent-Child RelationsParentsPatient CompliancePersonality AssessmentPsychiatric Status Rating ScalesRisperidoneSelf-Injurious BehaviorTreatment OutcomeConceptsParent trainingAdaptive functioningPervasive developmental disorderMeasures of noncomplianceBehavioral interventionsSymptom reductionDevelopmental disordersTraining targetClinical treatment targetsTrial design challengesTreatment targetsFunctioningTrainingFunctional improvementLow doseTreatment groupsMedicationsClinical practiceTantrumsAggressionBeneficial effectsIrritabilityChildrenNoncomplianceDisordersFour-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents, and Adults
Stewart SE, Rosario MC, Baer L, Carter AS, Brown TA, Scharf JM, Illmann C, Leckman JF, Sukhodolsky D, Katsovich L, Rasmussen S, Goodman W, Delorme R, Leboyer M, Chabane N, Jenike MA, Geller DA, Pauls DL. Four-Factor Structure of Obsessive-Compulsive Disorder Symptoms in Children, Adolescents, and Adults. Journal Of The American Academy Of Child & Adolescent Psychiatry 2008, 47: 763-772. PMID: 18520961, DOI: 10.1097/chi.0b013e318172ef1e.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsChildFemaleHumansMaleModels, StatisticalObsessive-Compulsive DisorderPersonality AssessmentPsychometricsReproducibility of ResultsConceptsConfirmatory factor analysisAdult age groupsAge groupsAge group samplesAdult groupFour-factor solutionOngoing translational researchSymptom dimensionsPrevious confirmatory factor analysisObsessive-compulsive disorder symptomsMultiple-group confirmatory factor analysisCategory-based modelComparable model fitOCD symptom dimensions
2007
Parent-Rated Anxiety Symptoms in Children with Pervasive Developmental Disorders: Frequency and Association with Core Autism Symptoms and Cognitive Functioning
Sukhodolsky DG, Scahill L, Gadow KD, Arnold LE, Aman MG, McDougle CJ, McCracken JT, Tierney E, Williams White S, Lecavalier L, Vitiello B. Parent-Rated Anxiety Symptoms in Children with Pervasive Developmental Disorders: Frequency and Association with Core Autism Symptoms and Cognitive Functioning. Research On Child And Adolescent Psychopathology 2007, 36: 117-128. PMID: 17674186, DOI: 10.1007/s10802-007-9165-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAntipsychotic AgentsAnxietyAsperger SyndromeAttention Deficit Disorder with HyperactivityAutistic DisorderCentral Nervous System StimulantsChildChild Development Disorders, PervasiveChild, PreschoolCognition DisordersComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIntelligenceLanguage Development DisordersMaleMethylphenidatePersonality AssessmentRandomized Controlled Trials as TopicRisperidoneSocial BehaviorStereotyped BehaviorConceptsPervasive developmental disorderParent-rated anxiety symptomsAnxiety symptomsHigher IQCore symptomsDevelopmental disordersCore autism symptomsAdolescent Symptom InventoryFunctional language useMedication-free childrenSocial anxietyAutism symptomsCognitive functioningParent ratingsSocial reciprocityResultsForty-three percentProblem behaviorAnxiety disordersSymptom InventoryOverall impairmentAnxietyGreater impairmentLanguage useStereotyped behaviorIQ