2023
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrusProtocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome
Awasthi J, Harris-Starling C, Kalvin C, Pittman B, Park H, Bloch M, Fernandez T, Sukhodolsky D, Hampson M. Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome. Psychiatry Research Neuroimaging 2023, 336: 111692. PMID: 37673711, PMCID: PMC10722977, DOI: 10.1016/j.pscychresns.2023.111692.Peer-Reviewed Case Reports and Technical NotesConceptsTourette syndromeFunctional magnetic resonance imagingStudy protocolChronic tic disorderSupplementary motor areaLower functional connectivityMagnetic resonance imagingResearch study protocolLarge trialsClinical trialsTic disordersMotor areaBrain areasControl groupResonance imagingBrain regionsNew trialsFunctional connectivityNeurofeedback interventionFMRI neurofeedbackNF protocolTrialsNF studiesSyndromeIntervention
2022
Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome
Morand-Beaulieu S, Crowley MJ, Grantz H, Leckman JF, Scahill L, Sukhodolsky DG. Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome. Clinical Neurophysiology 2022, 142: 75-85. PMID: 35987093, DOI: 10.1016/j.clinph.2022.07.500.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionGo/NoGo taskTourette syndromeTreatment outcomesEEG coherenceTic severityNoGo taskBehavioral interventionsFirst-line treatmentTic Severity ScaleClinical outcomesMotor areaSeverity ScaleAlpha frequency bandBlinded evaluatorsTic controlMotor responseEEG biomarkersOutcomesSyndromeBrain mechanismsSeverityInterventionSocial and Adaptive Functioning in Tourette Syndrome
Sukhodolsky D, Kalvin C, Artukoğlu B, Eicher V, Leckman J. Social and Adaptive Functioning in Tourette Syndrome. 2022, 391-404. DOI: 10.1093/med/9780197543214.003.0023.Peer-Reviewed Original ResearchAdaptive functioningAttention-deficit/hyperactivity disorderTourette syndromeThorough clinical assessmentCo-occurring disordersHyperactivity disorderQuality of lifePsychosocial interventionsClinical assessmentBehavioral disordersSymptom severityFunctioningStandardized ratingsDisordersActive investigationImpairmentSyndromeSeverityControl of actions and tics: A psychophysiological perspective
Morand-Beaulieu S, Jordan R, Baldwin E, Zhong J, Sukhodolsky D. Control of actions and tics: A psychophysiological perspective. International Review Of Movement Disorders 2022, 3: 343-363. DOI: 10.1016/bs.irmvd.2022.01.003.Peer-Reviewed Original ResearchTourette syndromeFunctional magnetic resonance imagingTic suppressionInhibitory controlMagnetic resonance imagingChronic ticsResonance imagingBrain correlatesBrain activityPsychophysiological studiesInhibitory control taskPsychophysiological correlatesControl of actionCorrelatesPsychophysiological techniquesSyndromeControlSuppressionStudy
2018
Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome
Tudor M, Bertschinger E, Piasecka J, Sukhodolsky D. Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome. Clinical Case Studies 2018, 17: 220-232. DOI: 10.1177/1534650118782438.ChaptersTourette syndromeOppositional defiant disorderAnger outburstsPrimary clinical concernContext of TSBehavioral therapy treatmentCognitive behavioral therapy treatmentCognitive behavioral therapySelect supplementsUseful treatmentMotor ticsDisruptive behaviorClinical concernPosttreatment assessmentBehavioral therapyWeekly sessionsAnxiety disordersTherapy treatmentSyndromeNeurodevelopmental disordersSignificant decreaseDefiant disorderInitial assessmentDisordersAggressive behavior
2013
Social and Adaptive Functioning in Tourette Syndrome
Sukhodolsky D, Eicher V, Leckman J. Social and Adaptive Functioning in Tourette Syndrome. 2013, 468-484. DOI: 10.1093/med/9780199796267.003.0021.ChaptersHabit reversal training for the treatment of tics in Tourette syndrome
Kapci E, Sukhodolsky D. Habit reversal training for the treatment of tics in Tourette syndrome. Anatolian Journal Of Psychiatry 2013, 14: 167. DOI: 10.5455/apd.35928.Peer-Reviewed Original Research
2009
Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior
Sukhodolsky DG, Vitulano LA, Carroll DH, McGuire J, Leckman JF, Scahill L. Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 413-421. PMID: 19242384, DOI: 10.1097/chi.0b013e3181985050.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleTourette syndromeACT groupControl trainingTAU control groupPrimary outcome measureIndependent evaluatorsAnger control trainingRating Scale scoresDisruptive behaviorEnd point evaluationLarge trialsBehavior rating scale scoresRandomized subjectsTAU conditionOutcome measuresScale scoreControl groupSyndromeRating ScaleACT conditionBehavior Rating ScaleAdolescentsTrialsDisruptive Behavior Rating Scale
2007
The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder
Sukhodolsky DG, Leckman JF, Rothenberger A, Scahill L. The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry 2007, 16: 51-59. PMID: 17665283, DOI: 10.1007/s00787-007-1007-3.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderTourette syndromeAbnormal neural oscillationsOscillatory activityHyperactivity disorderAbnormal oscillatory activityThalamo-cortical circuitsSymptoms of ADHDNeural oscillationsNeural oscillatory activityBasal gangliaFunctional abnormalitiesNormal brainThalamocortical regionsThalamocortical oscillationsCortical regionsTransient hyperpolarizationPrefrontal cortexNeural activityNeural communicationPathophysiologyMotor controlSyndromeBrainDisorders