2023
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrus
2022
Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome
Morand-Beaulieu S, Crowley MJ, Grantz H, Leckman JF, Scahill L, Sukhodolsky DG. Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome. Clinical Neurophysiology 2022, 142: 75-85. PMID: 35987093, DOI: 10.1016/j.clinph.2022.07.500.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionGo/NoGo taskTourette syndromeTreatment outcomesEEG coherenceTic severityNoGo taskBehavioral interventionsFirst-line treatmentTic Severity ScaleClinical outcomesMotor areaSeverity ScaleAlpha frequency bandBlinded evaluatorsTic controlMotor responseEEG biomarkersOutcomesSyndromeBrain mechanismsSeverityIntervention
2021
Organizational skills training for children with ADHD: study protocol for a randomized, controlled trial
Bikic A, Dalsgaard S, Olsen KD, Sukhodolsky DG. Organizational skills training for children with ADHD: study protocol for a randomized, controlled trial. Trials 2021, 22: 752. PMID: 34715906, PMCID: PMC8556963, DOI: 10.1186/s13063-021-05499-9.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderOrganizational skills trainingOrganizational skillsPoor organizational skillsWeekly therapy sessionsUsual control groupInattention ratingsSustained attentionSkill deficitsParent ratingsHyperactivity disorderLives of childrenNeurocognitive testsSchool functioningSkills trainingGroup formatCognitive functionBehavioral interventionsSkills ScalePresent deficitsAcademic performanceWeekly sessionsInattentionTherapy sessionsTreatment response
2019
Behavioral Interventions for Irritability in Children and Adolescents
Sukhodolsky D, Gladstone T, Marsh C, Cimino K. Behavioral Interventions for Irritability in Children and Adolescents. 2019, 255-274. DOI: 10.1093/med-psych/9780190846800.003.0013.Peer-Reviewed Original ResearchParent management trainingCognitive behavioral therapyDialectical behavior therapySocial problem-solving skillsDisruptive mood dysregulation disorderProblem-solving skillsCo-occurring symptomsDimensions of psychopathologyEmotion regulationEmotion dysregulationAversive patternInterpersonal conflictChild noncomplianceAnger outburstsBehavior therapyBehavioral skillsFamily interactionsBehavioral principlesForm of interventionBehavioral interventionsChildhood disordersAcceptance techniquesManagement trainingAggressive behaviorTreatment studies
2017
Tics and Tourette Syndrome
Sukhodolsky D, Gladstone T, Kaushal S, Piasecka J, Leckman J. Tics and Tourette Syndrome. Autism And Child Psychopathology Series 2017, 241-256. DOI: 10.1007/978-3-319-71210-9_14.ChaptersHabit reversal trainingTourette syndromeBehavioral interventionsPathophysiology of TSComprehensive clinical careComprehensive Behavioral InterventionCore clinical characteristicsAttention-deficit/hyperactivity disorderModerators of responseCo-occurring conditionsDisruptive behavior disordersClinical characteristicsChronic motorClinical efficacyTic expressionVocal ticsClinical recommendationsCo-occurring psychopathologyClinical careTic severityTreatment approachesPremonitory urgesBehavior disorderAnxiety disordersDiagnostic assessment
2016
Brain responses to biological motion predict treatment outcome in young children with autism
Yang D, Pelphrey KA, Sukhodolsky DG, Crowley MJ, Dayan E, Dvornek NC, Venkataraman A, Duncan J, Staib L, Ventola P. Brain responses to biological motion predict treatment outcome in young children with autism. Translational Psychiatry 2016, 6: e948-e948. PMID: 27845779, PMCID: PMC5314125, DOI: 10.1038/tp.2016.213.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderYoung childrenSocial information processingMultivariate pattern analysisMotivation/rewardBiological motionCore deficitComplex neurodevelopmental disorderBrain responsesResponse treatmentSpectrum disorderNeurobiological markersNeural predictorsInformation processingBehavioral interventionsIndividual childrenNeurodevelopmental disordersCurrent findingsNeural circuitsBehavioral deficitsEarly childhoodChildrenUnsuccessful interventionsNeurobiomarkersPattern analysisBehavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents
Sukhodolsky DG, Smith SD, McCauley SA, Ibrahim K, Piasecka JB. Behavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 58-64. PMID: 26745682, PMCID: PMC4808268, DOI: 10.1089/cap.2015.0120.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyParent management trainingAnger/irritabilityTransdiagnostic approachBehavioral interventionsDisruptive behaviorAggressive behaviorChild disruptive behaviorCallous-unemotional traitsDisruptive behavior disordersTreatment of irritabilityEmotion regulationAversive patternFamily interactionsBehavioral problemsAngerMental health referralsAggressionManagement trainingBehavior disorderMood disordersTreatment targetsIrritabilityChildrenPsychiatric diagnosis
2013
Phenomenology of Tics and Sensory Urges: The Self Under Siege
Leckman J, Bloch M, Sukhodolsky D, Scahill L, King R. Phenomenology of Tics and Sensory Urges: The Self Under Siege. 2013, 3-25. DOI: 10.1093/med/9780199796267.003.0001.Peer-Reviewed Original ResearchAcademic outcomesComorbid behavioral problemsNovel behavioral interventionKey phenomenological featuresCognitive domainsIrrelevant informationBehavioral problemsBehavioral interventionsPhenomenology of ticsTourette syndromeLong-term outcomesPhenomenological featuresTic expressionTic disordersEnvironmental contextReduced abilitySensory urgeOutside worldRelated disordersEducational objectivesPhenomenological spectrum
2012
Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome
Wilhelm S, Peterson AL, Piacentini J, Woods DW, Deckersbach T, Sukhodolsky DG, Chang S, Liu H, Dziura J, Walkup JT, Scahill L. Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome. JAMA Psychiatry 2012, 69: 795-803. PMID: 22868933, PMCID: PMC3772729, DOI: 10.1001/archgenpsychiatry.2011.1528.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionTic Severity ScaleTourette syndromeBehavior therapySeverity ScaleBehavioral interventionsOutpatient research clinicTotal tic scoreLeast moderate severityChronic tic disorderGreater mean decreaseMonthly booster sessionsAdult patientsSupportive treatmentModerate severityTic scoreTic disordersPositive respondersResearch clinicBooster sessionsMean decreasePosttreatment evaluationPatients
2008
Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders
Scahill L, Aman MG, McDougle CJ, Arnold LE, McCracken JT, Handen B, Johnson C, Dziura J, Butter E, Sukhodolsky D, Swiezy N, Mulick J, Stigler K, Bearss K, Ritz L, Wagner A, Vitiello B. Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders. Journal Of Autism And Developmental Disorders 2008, 39: 720-729. PMID: 19096921, PMCID: PMC4807607, DOI: 10.1007/s10803-008-0675-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionBehavior TherapyChildChild Development Disorders, PervasiveCombined Modality TherapyDopamine AntagonistsFemaleHumansMaleOutpatientsParent-Child RelationsParentsPatient CompliancePersonality AssessmentPsychiatric Status Rating ScalesRisperidoneSelf-Injurious BehaviorTreatment OutcomeConceptsParent trainingAdaptive functioningPervasive developmental disorderMeasures of noncomplianceBehavioral interventionsSymptom reductionDevelopmental disordersTraining targetClinical treatment targetsTrial design challengesTreatment targetsFunctioningTrainingFunctional improvementLow doseTreatment groupsMedicationsClinical practiceTantrumsAggressionBeneficial effectsIrritabilityChildrenNoncomplianceDisorders
2007
Development of a parent training program for children with pervasive developmental disorders
Johnson C, Handen B, Butter E, Wagner A, Mulick J, Sukhodolsky D, Williams S, Swiezy N, Arnold L, Aman M, Scahill L, Stigler K, McDougle C, Vitiello B, Smith T. Development of a parent training program for children with pervasive developmental disorders. Behavioral Interventions 2007, 22: 201-221. DOI: 10.1002/bin.237.Peer-Reviewed Original ResearchPervasive developmental disorderApplied behavior analysisBehavioral parent training programParent training programSingle-subject design methodologyAdaptive functioningChild functioningPsychosocial interventionsTreatment fidelityBehavioral interventionsTraining procedureDevelopmental disordersPT programImportant next stepTraining programPediatric psychopharmacologyFunctioningLarge sampleMultisite studyParentsBehavior analysisInterventionMeaningful outcomesChildrenPharmacological treatment