2020
Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments
Garg D, Johnstone E, Lomo L, Fair D, Rosen M, Taylor R, Silver B, Letourneau J. Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments. Journal Of Assisted Reproduction And Genetics 2020, 37: 1467-1476. PMID: 32342270, PMCID: PMC7311602, DOI: 10.1007/s10815-020-01792-9.Peer-Reviewed Original ResearchConceptsCancer survivorsPregnancy complicationsObstetrical outcomesFertility-preserving treatmentLow birth weightPoor obstetrical outcomesFemale cancer survivorsImpact of chemotherapyEarly pregnancy lossOncofertility carePregnancy implantationLate complicationsPregnancy outcomesPreterm birthRadiation fibrosisEndometrial receptivityGonadotoxic effectsUterine injuryBirth weightPregnancy lossPregnant uterusBlood supplyUterine functionChemotherapyComplicationsChapter 1 Neuroendocrine mechanisms of reproduction
Garg D, Berga SL. Chapter 1 Neuroendocrine mechanisms of reproduction. Handbook Of Clinical Neurology 2020, 171: 3-23. PMID: 32736757, DOI: 10.1016/b978-0-444-64239-4.00001-1.Peer-Reviewed Original ResearchConceptsGnRH driveNeuroendocrinology of reproductionReproductive functionFunctional hypothalamic amenorrheaSex steroid hormone synthesisFollicle-stimulating hormoneGonadotropin-releasing hormoneStress-induced anovulationSteroid hormone synthesisAbsence of oocytesHypothalamic amenorrheaHypothalamic hypogonadismCongenital causesCeliac diseaseMenstrual cyclePsychogenic amenorrheaCommon causeGonadal axisEndocrine effectsAnterior pituitaryBrain tumorsBehavioral variablesSecondary insufficiencyAppropriate secretionNeuroendocrine mechanisms
2019
Oncofertility conundrum: discrepancy between anti-Mϋllerian hormone and mature oocyte yield in a peripubertal girl with Hodgkin lymphoma
Garg D, Johnstone E, Fair D, Carrell D, Berga S, Letourneau J. Oncofertility conundrum: discrepancy between anti-Mϋllerian hormone and mature oocyte yield in a peripubertal girl with Hodgkin lymphoma. Journal Of Assisted Reproduction And Genetics 2019, 36: 1753-1756. PMID: 31313012, PMCID: PMC6708038, DOI: 10.1007/s10815-019-01516-8.Peer-Reviewed Original Research
2017
Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS
Garg D, Grazi R, Lambert-Messerlian GM, Merhi Z. Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. Journal Of Assisted Reproduction And Genetics 2017, 34: 1507-1513. PMID: 28825156, PMCID: PMC5699991, DOI: 10.1007/s10815-017-1011-6.Peer-Reviewed Original ResearchConceptsAdvanced glycation end productsFollicular fluidVitamin DPro-inflammatory advanced glycation end productsHigher anti-Mullerian hormone levelsAnti-Mullerian hormone levelsProtective anti-inflammatory roleFollicular fluid levelsLevels of sRAGEAnti-inflammatory rolePathogenesis of PCOSGlycation end productsPotential therapeutic targetDay 5 embryosConclusionsIn womenSRAGE levelsOvarian dysfunctionOvarian levelHormone levelsPCOSSRAGESoluble receptorTherapeutic targetDay 3Fluid levelsProgesterone-Mediated Non-Classical Signaling
Garg D, Ng S, Baig K, Driggers P, Segars J. Progesterone-Mediated Non-Classical Signaling. Trends In Endocrinology And Metabolism 2017, 28: 656-668. PMID: 28651856, DOI: 10.1016/j.tem.2017.05.006.Peer-Reviewed Original ResearchConceptsProgesterone response elementGrowth factor signalingNon-genomic signalingNon-classical signaling pathwaysNon-classical signalingCycle regulationFactor signalingSignaling pathwaysResponse elementProgesterone signalingCell growthSignalingProgesterone receptorSubsequent activationNovel therapeutic strategiesHormone actionProgesterone actionPathwayGrowth factorImportant physiological actionsPhysiological actionsMenstrual cycle regulationNuclear progesterone receptorRecent studiesActivation
2016
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS
Garg D, Merhi Z. Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS. Reproductive Biology And Endocrinology 2016, 14: 71. PMID: 27769286, PMCID: PMC5073880, DOI: 10.1186/s12958-016-0205-6.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxysteroid DehydrogenasesAnimalsCholesterol Side-Chain Cleavage EnzymeFemaleGlycation End Products, AdvancedGonadal Steroid HormonesGranulosa CellsHumansOvaryPhosphoproteinsPolycystic Ovary SyndromeReceptors, LHReceptors, PeptideReceptors, Transforming Growth Factor betaSteroid 17-alpha-HydroxylaseTheca CellsConceptsAdvanced glycation end productsOvaries of womenTheca cell functionGlycation end productsCell functionHormone receptor expressionSteroidogenic enzyme activitiesSteroidogenic acute regulatory proteinAbnormal steroidogenesisPCOS modelOvarian dysfunctionAcute regulatory proteinReceptor expressionPCOSFollicular developmentTheca cellsGranulosa cellsSystematic reviewNew interventionsHormone receptorsEnzyme cytochrome P450SteroidogenesisEnd productsGranulosaCytochrome P450The role of AMH in the pathophysiology of polycystic ovarian syndrome
Garg D, Tal R. The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reproductive BioMedicine Online 2016, 33: 15-28. PMID: 27174394, DOI: 10.1016/j.rbmo.2016.04.007.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeAnti-Müllerian hormoneOvarian syndromePathophysiology of PCOSTreatment of PCOSRole of AMHLaparoscopic ovarian drillingReproductive-age womenSerum AMH concentrationsNew treatment modalitiesFollicular arrestOvarian drillingOvulation inductionClinical parametersInsulin resistanceAMH concentrationsTreatment modalitiesAge womenEndocrine alterationsPoor responseAromatase productionAMH declinePCOS pathogenesisFollicular developmentHelp cliniciansBilateral ovarian maldescent: Unusual cause of infertility – A case report and literature review
Garg D, Grazi R, Kankanala N, Melzer-Ross K. Bilateral ovarian maldescent: Unusual cause of infertility – A case report and literature review. Journal Of Obstetrics And Gynaecology Research 2016, 42: 1038-1041. PMID: 27094464, DOI: 10.1111/jog.13019.Peer-Reviewed Original ResearchConceptsOvarian maldescentOvulation induction/intrauterine inseminationNormal uterine anatomyPatient underwent laparoscopyFresh embryo transferCases of infertilityUnderwent laparoscopyUnexplained infertilityPrimary infertilityUterine anomaliesUnusual causeBilateral ovariesRare entityUterine anatomyCase reportIntrauterine inseminationFuture fertilityPelvic brimNormal uterusInfertility treatmentFollicular aspirationEmbryo transferAccurate diagnosisInfertilityBenign nature
2015
Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS?
Garg D, Merhi Z. Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS? Nutrients 2015, 7: 10129-10144. PMID: 26690206, PMCID: PMC4690076, DOI: 10.3390/nu7125524.Peer-Reviewed Original ResearchConceptsOvulatory dysfunctionAdvanced glycation end productsHigh AGE dietReproductive-aged womenPro-inflammatory receptorGlycation end productsDietary AGEsPharmacological therapyOvulatory problemsExpression of AGEsCommon causeOvarian healthPCOSOvarian tissueAnovulationModification of foodVariety of dietsWomenAgeDysfunctionDietReproductive alterationsSubsequent developmentNon-enzymatic reactionEnd productsLate Postpartum Eclampsia with Postpartum Angiopathy: An Uncommon Diagnosis in the Emergency Department
Garg D, Rahaman B, Stein EG, Dickman E. Late Postpartum Eclampsia with Postpartum Angiopathy: An Uncommon Diagnosis in the Emergency Department. Journal Of Emergency Medicine 2015, 49: e187-e191. PMID: 26409671, DOI: 10.1016/j.jemermed.2015.07.019.Peer-Reviewed Original ResearchConceptsLate postpartum eclampsiaEmergency departmentPostpartum eclampsiaMedical intensive care unitGeneralized tonic-clonic seizuresFurther seizure activityPossibility of preeclampsiaBlood pressure controlControl of seizuresNormal vaginal deliveryRare clinical entityTonic-clonic seizuresPast medical historyIntensive care unitBeats/minOccurrence of eclampsiaPostpartum angiopathyUndifferentiated headacheEntire pregnancyNonspecific symptomsBlood pressureVaginal deliveryCare unitChief complaintBlurry visionEndometrial osseous metaplasia: an unusual cause of infertility
Garg D, Bekker G, Akselrod F, Narasimhulu D. Endometrial osseous metaplasia: an unusual cause of infertility. BMJ Case Reports 2015, 2015: bcr2015209523. PMID: 25837325, PMCID: PMC4401972, DOI: 10.1136/bcr-2015-209523.Peer-Reviewed Original ResearchA rare case of fatal stroke after ethylene glycol toxicity
Garg D, Lim T, Irani M. A rare case of fatal stroke after ethylene glycol toxicity. BMJ Case Reports 2015, 2015: bcr2014208855. PMID: 25809433, PMCID: PMC4386312, DOI: 10.1136/bcr-2014-208855.Peer-Reviewed Original ResearchConceptsEthylene glycol toxicityGlycol toxicityAcute left-sided weaknessFurther blood testsLeft-sided weaknessSerum osmolal gapNeurological improvementFatal strokeAcute infarctionGeneralised oedemaBlood testsEmergency departmentOsmolal gapAnion gapBrain MRIRare casePatientsVisual fieldAcetone odorMOsm/StrokeToxicityTimely fashionDaysFomepizole