2022
Effect of chemotherapy on the uterus of young adult cancer survivors
Garg D, Hodgman M, Reil S, Lomo L, Aston K, Hill J, Johnstone E, Jenkins T, Letourneau J. Effect of chemotherapy on the uterus of young adult cancer survivors. F&S Reports 2022, 3: 198-203. PMID: 36212573, PMCID: PMC9532891, DOI: 10.1016/j.xfre.2022.05.008.Peer-Reviewed Original ResearchEndometrial thicknessChemotherapy exposureEndometrial biopsyUterine volumeCancer survivorsHodgkin's lymphomaMenstrual cycleDeoxyribonucleic acid (DNA) methylation patternsCross-sectional pilot studyYoung adult cancer survivorsImpact of chemotherapyRibonucleic acid expression levelsEffect of chemotherapyAdult cancer survivorsGeneral population controlsLate proliferative phaseMedian uterine volumeUniversity fertility clinicPelvic radiationEndometrial histologyPelvic ultrasoundCervical cancerFalse-positive resultsMenstruating womenStudy visit
2021
Cancer treatment is associated with a measurable decrease in live births in a large, population-based study
Garg D, Meeks H, Johnstone E, Berga S, Smith K, Hotaling J, Letourneau J. Cancer treatment is associated with a measurable decrease in live births in a large, population-based study. F&S Reports 2021, 2: 462-467. PMID: 34934988, PMCID: PMC8655402, DOI: 10.1016/j.xfre.2021.08.004.Peer-Reviewed Original ResearchIncidence rate ratiosPopulation-based studyLive birth rateAge-matched controlsLive birthsCancer survivorsCancer typesHealthy controlsBreast cancerLower live birth ratesCancer treatmentCentral nervous system cancerRetrospective cohort studyFemale cancer patientsNon-cancer controlsNervous system cancersAge 18 yearsCommon cancer typesSoft tissue cancerBirth rateCohort studyGastrointestinal cancerCancer patientsSystem cancersMAIN OUTCOME
2020
Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments
Garg D, Johnstone E, Lomo L, Fair D, Rosen M, Taylor R, Silver B, Letourneau J. Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments. Journal Of Assisted Reproduction And Genetics 2020, 37: 1467-1476. PMID: 32342270, PMCID: PMC7311602, DOI: 10.1007/s10815-020-01792-9.Peer-Reviewed Original ResearchConceptsCancer survivorsPregnancy complicationsObstetrical outcomesFertility-preserving treatmentLow birth weightPoor obstetrical outcomesFemale cancer survivorsImpact of chemotherapyEarly pregnancy lossOncofertility carePregnancy implantationLate complicationsPregnancy outcomesPreterm birthRadiation fibrosisEndometrial receptivityGonadotoxic effectsUterine injuryBirth weightPregnancy lossPregnant uterusBlood supplyUterine functionChemotherapyComplications