2021
In vivo evidence of lower synaptic vesicle density in schizophrenia
Radhakrishnan R, Skosnik PD, Ranganathan M, Naganawa M, Toyonaga T, Finnema S, Hillmer AT, Esterlis I, Huang Y, Nabulsi N, Carson RE, D’Souza D. In vivo evidence of lower synaptic vesicle density in schizophrenia. Molecular Psychiatry 2021, 26: 7690-7698. PMID: 34135473, DOI: 10.1038/s41380-021-01184-0.Peer-Reviewed Original ResearchConceptsSynaptic vesicle densityHealthy controlsVesicle densityHigh-resolution research tomographySynaptic densitySCZ patientsVivo measuresNovel positron emission tomography (PET) ligandGender-matched healthy controlsCumulative antipsychotic exposurePositron emission tomography (PET) ligandSynaptic spine densityPsychosis symptom severityGray matter volumeJ bindingAntipsychotic exposureSpine densityDisease progressionFrontal cortexOccipital cortexTomography ligandTemporal cortexAnterior cingulateVivo findingsParietal cortex
2012
Lower β2*-Nicotinic Acetylcholine Receptor Availability in Smokers With Schizophrenia
D'Souza DC, Esterlis I, Carbuto M, Krasenics M, Seibyl J, Bois F, Pittman B, Ranganathan M, Cosgrove K, Staley J. Lower β2*-Nicotinic Acetylcholine Receptor Availability in Smokers With Schizophrenia. American Journal Of Psychiatry 2012, 169: 326-334. PMID: 22193533, PMCID: PMC3881431, DOI: 10.1176/appi.ajp.2011.11020189.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptor availabilityNicotinic acetylcholine receptorsReceptor availabilityNegative symptomsAcetylcholine receptorsNicotinic acetylcholine receptor systemHealthy tobacco smokersAcetylcholine receptor systemDevelopment of medicationsSingle photon emissionIA-85380Agonist radiotracerTobacco smokersCigarette smokingAvailability of receptorsSmoking abstinenceNicotine actionPostmortem studiesFrontal cortexSmokersSmokingVivo findingsParietal cortexReceptor systemSymptoms