2019
Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors
Chen H, Thomas C, Munoz FA, Alexandrescu S, Horbinski CM, Olar A, McGuone D, Camelo-Piragua S, Wang L, Pentsova E, Phillips J, Aldape K, Chen W, Iafrate AJ, S AS, Zagzag D, Golfinos JG, Placantonakis DG, Rosenblum M, Ohman-Strickland P, Hameed M, Snuderl M. Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors. Neuro-Oncology 2019, 21: 1164-1174. PMID: 31140557, PMCID: PMC7571489, DOI: 10.1093/neuonc/noz098.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAneuploidyBrain NeoplasmsChemotherapy, AdjuvantChildChromosomal InstabilityChromosome DeletionChromosomes, Human, Pair 1Chromosomes, Human, Pair 19FemaleHumansIn Situ Hybridization, FluorescenceIsocitrate DehydrogenaseMaleMiddle AgedNeoadjuvant TherapyNeurosurgical ProceduresOligodendrogliomaPrognosisProgression-Free SurvivalRadiotherapy, AdjuvantSurvival RateYoung AdultConceptsProgression-free survivalOverall survivalOligodendroglial tumorsPrognostic significanceBetter progression-free survivalLonger progression-free survivalPolysomic cellsCodeletion of 1p/19qPresence of polysomyEarly recurrenceShorter survivalPoor outcomeEarly progressionPatientsTumorsSurvivalPolysomySitu hybridizationCodeletionChromosomal instabilityCellsGroupPrior studiesStatusRecurrence
2017
Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis
Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis. Diabetes 2017, 66: db161035. PMID: 28400392, PMCID: PMC5482092, DOI: 10.2337/db16-1035.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsCell MovementCell ProliferationCore Binding Factor Alpha 2 SubunitDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic RetinopathyDisease Models, AnimalEndothelial CellsFemaleGlucoseHumansImmunohistochemistryMaleMiceMiddle AgedOxygenRetinaRetinal NeovascularizationRNA, MessengerConceptsAberrant retinal angiogenesisHuman retinal microvascular endothelial cellsProliferative diabetic retinopathyOxygen-induced retinopathyFibrovascular membranesRetinal angiogenesisEndothelial cellsRetinal microvascular endothelial cellsType 2 diabetesRetina of miceMicrovascular endothelial cellsVascular endothelial cellsNeovascular tuftsDiabetic retinopathyTranscription factor 1Common causeRUNX1 inhibitionImmunohistochemical stainingAdult populationHigh glucoseType 1RetinopathyProtein expressionTube formationFactor 1
2015
Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes.
Marciscano AE, Stemmer-Rachamimov AO, Niemierko A, Larvie M, Curry WT, Barker FG, Martuza RL, McGuone D, Oh KS, Loeffler JS, Shih HA. Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes. Journal Of Neurosurgery 2015, 124: 106-14. PMID: 26274991, DOI: 10.3171/2015.1.jns142228.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCombined Modality TherapyDisease ProgressionFemaleFollow-Up StudiesHumansKi-67 AntigenMaleMeningiomaMiddle AgedNeoplasm Recurrence, LocalNeurosurgical ProceduresPrognosisRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentTreatment OutcomeWorld Health OrganizationYoung AdultConceptsAtypical featuresBenign meningiomasWorld Health Organization (WHO) grade I meningiomasSimpson grade IIMIB-1 labeling indexAtypical histological featuresProgression/recurrenceHigh-risk groupStratification of patientsSimpson grade resectionGrade I meningiomasMedian followConclusions PatientsActuarial rateAdditional surgeryClinical outcomesInitial treatmentHistopathological featuresPrognostic significanceHistological factorsHistological featuresGrade IGrade IIPathological diagnosisInclusion criteriaCharacterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy.
Kim LA, Wong LL, Amarnani DS, Bigger-Allen AA, Hu Y, Marko CK, Eliott D, Shah VA, McGuone D, Stemmer-Rachamimov AO, Gai X, D'Amore PA, Arboleda-Velasquez JF. Characterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy. Molecular Vision 2015, 21: 673-87. PMID: 26120272, PMCID: PMC4462955.Peer-Reviewed Original ResearchConceptsComparative genomic hybridizationDiscovery of cellsPlasma membrane infoldingsSpecific cell populationsCell identityPrimary culturesCell culture modelCharacterization of cellsMajor chromosomal aberrationsMembrane infoldingsCellular constituentsGenomic hybridizationAlpha-smooth muscle actinThrombospondin-1Cell populationsExpression of markersCulture conditionsStromal cellsPerivascular cellsCulture modelUnique resourceGlial fibrillary acidic protein-positive cellsCellsChromosomal aberrationsEndothelial cellsFailure to detect human papillomavirus in focal cortical dysplasia type IIb
Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ. Failure to detect human papillomavirus in focal cortical dysplasia type IIb. Annals Of Neurology 2015, 78: 63-67. PMID: 25893423, DOI: 10.1002/ana.24422.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasia type IIbFocal cortical dysplasiaHPV infectionCortical dysplasiaSurgical centersAbsence of HPVType IIBSingle surgical centerHuman papillomavirus 16Situ hybridizationHPV 16Human papillomavirusPolymerase chain reactionSurgical specimensDNA polymerase chain reactionIndependent cohortViral infectionFetal developmentPathological specimensInfectionCausative agentChain reactionCausal roleHPVDysplasia
2014
Case 18-2014 — A 32-Year-Old Man with a Rash, Myalgia, and Weakness
Cabot R, Rosenberg E, Harris N, Shepard J, Cort A, Ebeling S, McDonald E, Burgin S, Stone J, Shenoy-Bhangle A, McGuone D. Case 18-2014 — A 32-Year-Old Man with a Rash, Myalgia, and Weakness. New England Journal Of Medicine 2014, 370: 2327-2337. PMID: 24918376, DOI: 10.1056/nejmcpc1304161.Peer-Reviewed Original ResearchPhylogenetic and epidemiologic evidence of multiyear incubation in human rabies
Boland TA, McGuone D, Jindal J, Rocha M, Cumming M, Rupprecht CE, Barbosa TF, de Novaes Oliveira R, Chu CJ, Cole AJ, Kotait I, Kuzmina NA, Yager PA, Kuzmin IV, Hedley‐Whyte E, Brown CM, Rosenthal ES. Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies. Annals Of Neurology 2014, 75: 155-160. PMID: 24038455, PMCID: PMC4118733, DOI: 10.1002/ana.24016.Peer-Reviewed Original Research
2013
Case 18-2013 — A 32-Year-Old Woman with Recurrent Episodes of Altered Consciousness
Cabot R, Harris N, Rosenberg E, Shepard J, Cort A, Ebeling S, McDonald E, Cole A, Eskandar E, Mela T, Noebels J, Gonzalez R, McGuone D. Case 18-2013 — A 32-Year-Old Woman with Recurrent Episodes of Altered Consciousness. New England Journal Of Medicine 2013, 368: 2304-2312. PMID: 23758236, DOI: 10.1056/nejmcpc1215969.Peer-Reviewed Original Research