2014
Primary Care–Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence: A Randomized Clinical Trial
Fiellin DA, Schottenfeld RS, Cutter CJ, Moore BA, Barry DT, O’Connor P. Primary Care–Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence: A Randomized Clinical Trial. JAMA Internal Medicine 2014, 174: 1947-1954. PMID: 25330017, PMCID: PMC6167926, DOI: 10.1001/jamainternmed.2014.5302.Peer-Reviewed Original ResearchConceptsPrescription opioid dependenceOngoing maintenance therapyIllicit opioid useMaintenance therapyOpioid dependenceBuprenorphine taperBuprenorphine therapyTaper groupMaintenance groupOpioid usePrimary careClinical trialsPrimary care-based treatmentSignificant public health burdenBuprenorphine maintenance therapyOngoing maintenance treatmentPrimary care physiciansEvidence-based guidelinesPrimary care sitesPublic health burdenWeeks of stabilizationHydrochloride therapyOpioid withdrawalBuprenorphine treatmentNaltrexone treatmentPrevalence of psychiatric disorders among treatment-seeking individuals with co-occurring chronic pain and opioid dependence
Barry D, Cutter C, Beitel M, Liong C, Schottenfeld R. Prevalence of psychiatric disorders among treatment-seeking individuals with co-occurring chronic pain and opioid dependence. Drug And Alcohol Dependence 2014, 140: e11-e12. DOI: 10.1016/j.drugalcdep.2014.02.053.Peer-Reviewed Original Research
2013
Pain and Associated Substance Use among Opioid Dependent Individuals Seeking Office‐Based Treatment with Buprenorphine–Naloxone: A Needs Assessment Study
Barry DT, Savant JD, Beitel M, Cutter CJ, Moore BA, Schottenfeld RS, Fiellin DA. Pain and Associated Substance Use among Opioid Dependent Individuals Seeking Office‐Based Treatment with Buprenorphine–Naloxone: A Needs Assessment Study. American Journal On Addictions 2013, 22: 212-217. PMID: 23617861, PMCID: PMC3641684, DOI: 10.1111/j.1521-0391.2012.00327.x.Peer-Reviewed Original ResearchConceptsBuprenorphine-naloxone treatmentChronic painSubstance usePain intensityPast-week substance useCharacteristics of painCurrent pain intensityOpioid-dependent individualsTypical pain intensitySelf-reported substance useHigh rateBNT patientsBuprenorphine-naloxoneOpioid withdrawalPain frequencyPercent of respondentsPain durationPain locationPain subgroupsNerve damageOpioid dependencePain interferencePain typesConsecutive individualsPainTreating Pain in Patients Receiving Methadone Maintenance for Opioid Dependence
Alford D, Barry D, Fiellin D. Treating Pain in Patients Receiving Methadone Maintenance for Opioid Dependence. 2013, 31-37. DOI: 10.1007/978-1-4614-6974-2_3.ChaptersPain complaintsOpioid dependenceMethadone maintenanceChronic painOpioid-dependent patientsIllicit opioid useTreatment of painOpioid usePrescription opioidsMaintenance treatmentPain perceptionClinical challengePainPsychiatric disordersPatientsMethadonePhysiologic toleranceEffective coping skillsComplaintsOpioidsMedicationsTreatmentCoping skillsLoss of controlAddictionA Randomized Trial of Cognitive Behavioral Therapy in Primary Care-based Buprenorphine
Fiellin DA, Barry DT, Sullivan LE, Cutter CJ, Moore BA, O'Connor PG, Schottenfeld RS. A Randomized Trial of Cognitive Behavioral Therapy in Primary Care-based Buprenorphine. The American Journal Of Medicine 2013, 126: 74.e11-74.e17. PMID: 23260506, PMCID: PMC3621718, DOI: 10.1016/j.amjmed.2012.07.005.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPhysician managementBehavioral therapyOpioid useOpioid dependencePrimary careSelf-reported frequencyBuprenorphine/naloxone treatmentConsecutive weeksOpioid-dependent patientsIllicit opioid usePrimary care clinicsPrimary outcome measureWeeks of treatmentNaloxone treatmentOpioid abstinenceBuprenorphine/Care clinicsIllicit opioidsRandomized trialsUrine toxicologyClinical trialsStudy completionOutcome measuresCocaine use
2012
Use of Conventional, Complementary, and Alternative Treatments for Pain Among Individuals Seeking Primary Care Treatment With Buprenorphine-Naloxone
Barry DT, Savant JD, Beitel M, Cutter CJ, Moore BA, Schottenfeld RS, Fiellin DA. Use of Conventional, Complementary, and Alternative Treatments for Pain Among Individuals Seeking Primary Care Treatment With Buprenorphine-Naloxone. Journal Of Addiction Medicine 2012, 6: 274-279. PMID: 23041680, PMCID: PMC3492534, DOI: 10.1097/adm.0b013e31826d1df3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesicsAnalgesics, OpioidBuprenorphineBuprenorphine, Naloxone Drug CombinationChronic PainCombined Modality TherapyComorbidityComplementary TherapiesFemaleHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPrimary Health CareTreatment OutcomeUtilization ReviewConceptsBuprenorphine-naloxone treatmentPain treatmentOpioid dependenceTreatment useCP groupSP groupPain treatment modalitiesPain-related treatmentsPain management servicesPrimary care treatmentLifetime useBuprenorphine-naloxoneOpioid medicationsPain groupPain statusCare treatmentTreatment modalitiesAlternative treatmentMeasures of demographicsPainMedical useMedicationsTreatmentUse of ConventionalEfficacyBrief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients
Tetrault JM, Moore BA, Barry DT, O'Connor PG, Schottenfeld R, Fiellin DA, Fiellin LE. Brief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients. Journal Of Substance Use And Addiction Treatment 2012, 43: 433-439. PMID: 22938914, DOI: 10.1016/j.jsat.2012.07.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineBuprenorphine, Naloxone Drug CombinationCounselingDelivery of Health Care, IntegratedFeasibility StudiesFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPsychotherapy, BriefSubstance Abuse DetectionTime FactorsTreatment OutcomeViral LoadConceptsEnhanced medical managementPhysician managementDetectable HIV viral loadHIV treatment settingsOpioid-negative urinesBuprenorphine/naloxoneHIV viral loadOpioid-dependent patientsPercentage of subjectsUntreated opioid dependenceExtended counselingHIV clinicHIV outcomesBuprenorphine/Medical managementOpioid dependenceViral loadDependent patientsExtensive counselingClinical trialsContinuous abstinenceNegative urineTreatment settingsGroup differencesCounseling
2010
Exploring Relations Among Traumatic, Posttraumatic, and Physical Pain Experiences in Methadone-Maintained Patients
Barry DT, Beitel M, Cutter CJ, Garnet B, Joshi D, Rosenblum A, Schottenfeld RS. Exploring Relations Among Traumatic, Posttraumatic, and Physical Pain Experiences in Methadone-Maintained Patients. Journal Of Pain 2010, 12: 22-28. PMID: 20646965, PMCID: PMC2962776, DOI: 10.1016/j.jpain.2010.04.006.Peer-Reviewed Original ResearchConceptsSymptoms of PTSDPosttraumatic stress disorderTraumatic eventsChronic severe painSexual assaultMMT patientsPhysical assaultPain experienceLifetime trauma exposurePhysical pain experiencesMethadone maintenance treatment patientsMethadone-maintained patientsTrauma exposureFunction of sexStress disorderComparable levelsPTSD screenerPain statusSevere painChronic painOpioid dependenceTreatment patientsCSP groupPatientsPainConventional and Nonconventional Pain Treatment Utilization Among Opioid Dependent Individuals With Pain Seeking Methadone Maintenance Treatment: A Needs Assessment Study
Barry DT, Beitel M, Cutter CJ, Joshi D, Falcioni J, Schottenfeld RS. Conventional and Nonconventional Pain Treatment Utilization Among Opioid Dependent Individuals With Pain Seeking Methadone Maintenance Treatment: A Needs Assessment Study. Journal Of Addiction Medicine 2010, 4: 81-87. PMID: 21769025, PMCID: PMC2846657, DOI: 10.1097/adm.0b013e3181ac913a.Peer-Reviewed Original ResearchMethadone maintenance treatmentPain treatment utilizationPain treatmentMaintenance treatmentTreatment utilizationConventional pain treatmentAlternative medicine utilizationOpioid-dependent individualsTypical pain intensityRecent painPain reductionPain intensityChronic painOpioid dependenceCounter medicationsMMT programPhysical therapyMedicine utilizationPhysical exerciseAlternative medicinePainConventional medicineLifetime historyHeat therapyHistory status
2009
The Association between Cocaine Use and Treatment Outcomes in Patients Receiving Office‐Based Buprenorphine/Naloxone for the Treatment of Opioid Dependence
Sullivan LE, Moore BA, O'Connor PG, Barry DT, Chawarski MC, Schottenfeld RS, Fiellin DA. The Association between Cocaine Use and Treatment Outcomes in Patients Receiving Office‐Based Buprenorphine/Naloxone for the Treatment of Opioid Dependence. American Journal On Addictions 2009, 19: 53-58. PMID: 20132122, PMCID: PMC3107713, DOI: 10.1111/j.1521-0391.2009.00003.x.Peer-Reviewed Original ResearchConceptsOpioid-negative urinesBuprenorphine/naloxoneUrine toxicology testsWeeks of treatmentWorse treatment outcomesTreatment outcomesCocaine useTreatment retentionMean weekBuprenorphine/naloxone maintenanceGreater percentageToxicology testsUrine toxicology resultsOpioid dependenceToxicology resultsPatientsTargeted interventionsWeeksNaloxoneOutcomesTreatmentBaselineUrineAssociationPercentage
2008
Integrating Buprenorphine Treatment into Office-based Practice: a Qualitative Study
Barry DT, Irwin KS, Jones ES, Becker WC, Tetrault JM, Sullivan LE, Hansen H, O’Connor P, Schottenfeld RS, Fiellin DA. Integrating Buprenorphine Treatment into Office-based Practice: a Qualitative Study. Journal Of General Internal Medicine 2008, 24: 218-225. PMID: 19089500, PMCID: PMC2628993, DOI: 10.1007/s11606-008-0881-9.Peer-Reviewed Original ResearchConceptsBuprenorphine maintenance treatmentOffice-based practicePhysicians' perceptionsPatient-related barriersOffice-based physiciansLack of remunerationBuprenorphine treatmentOpioid dependenceMaintenance treatmentPhysician barriersMethadone maintenancePrimary careResultsEighty percentLow prevalenceClinical practiceMedical providersMultidisciplinary teamPatient careInternal medicinePhysician facilitatorsInfectious diseasesAddiction medicinePhysiciansQualitative software programDesignQualitative study
2007
Primary Care Office-based Buprenorphine Treatment: Comparison of Heroin and Prescription Opioid Dependent Patients
Moore BA, Fiellin DA, Barry DT, Sullivan LE, Chawarski MC, O’Connor P, Schottenfeld RS. Primary Care Office-based Buprenorphine Treatment: Comparison of Heroin and Prescription Opioid Dependent Patients. Journal Of General Internal Medicine 2007, 22: 527-530. PMID: 17372805, PMCID: PMC1829433, DOI: 10.1007/s11606-007-0129-0.Peer-Reviewed Original ResearchConceptsPrescription opioid useOpioid useOnly patientsPrescription opioidsTreatment outcomesBuprenorphine/naloxone maintenanceBuprenorphine/naloxone treatmentOpioid-negative urine samplesPrescription opioid-dependent patientsHepatitis C antibodyDrug treatment historyOpioid-dependent patientsPrimary care officesOffice-based settingClinical characteristicsBuprenorphine treatmentNaloxone treatmentBuprenorphine/Opioid dependenceCare officesDependent patientsTreatment responseC antibodyHeroin usePatients
2006
A Trial of Integrated Buprenorphine/Naloxone and HIV Clinical Care
Sullivan LE, Barry D, Moore BA, Chawarski MC, Tetrault JM, Pantalon MV, O'Connor PG, Schottenfeld RS, Fiellin DA. A Trial of Integrated Buprenorphine/Naloxone and HIV Clinical Care. Clinical Infectious Diseases 2006, 43: s184-s190. PMID: 17109305, DOI: 10.1086/508182.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, SublingualAdultAntiretroviral Therapy, Highly ActiveBuprenorphineDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPilot ProjectsProbabilityReference ValuesRisk FactorsTreatment OutcomeConceptsHIV clinical careHIV-1 RNA copies/mLBuprenorphine/naloxone treatmentRNA copies/mLCopies/mLOpioid dependenceClinical careOpioid useNaloxone treatmentPhysician managementTreatment retentionHIV type 1 RNA levelsHIV-1 RNA levelsDose of buprenorphinePartial opioid agonistRNA levelsCD4 lymphocyte countBuprenorphine/naloxoneOpioid-dependent patientsUrine toxicology testsWeeks of treatmentHuman immunodeficiency virusUrine test resultsBetter treatment retentionUntreated opioid dependence