2023
The Effects of Aging on Rod Bipolar Cell Ribbon Synapses
Shrestha A, Rameshkumar N, Boff J, Rajmanna R, Chandrasegaran T, Frederick C, Zenisek D, Vaithianathan T. The Effects of Aging on Rod Bipolar Cell Ribbon Synapses. Cells 2023, 12: 2385. PMID: 37830599, PMCID: PMC10572008, DOI: 10.3390/cells12192385.Peer-Reviewed Original ResearchConceptsRod bipolar cellsRibbon synapsesSynaptic ribbonsCalcium currentBipolar cellsRetinal ganglion cellsAge-related morphological changesBipolar cell ribbon synapsesBipolar cell terminalsGlobal health concernAge-related visual impairmentAge-related changesPlexiform layerGanglion cellsInner nuclearCochlear cellsSensory alterationsCell terminalsVisual impairmentFunctional changesHealth concernCalcium signalsSynapsesCalcium dynamicsRetinaRibbon Synapses and Retinal Disease: Review
Frederick C, Zenisek D. Ribbon Synapses and Retinal Disease: Review. International Journal Of Molecular Sciences 2023, 24: 5090. PMID: 36982165, PMCID: PMC10049380, DOI: 10.3390/ijms24065090.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPresynaptic protein complexesRibbon synapsesDefective synaptic transmissionMolecular machineryProtein complexesRetinal malfunctionSynaptic transmissionRetinal diseasesSynaptic ribbonsNeurotransmitter releaseMuscular dystrophyVisual diseaseSynapsesDiseaseSensory informationMutagenesisMachineryPresent understandingSynaptopathyVisual systemReviewPathogenesisRetinaPathology
2013
Synaptic Ribbons Influence the Size and Frequency of Miniature-like Evoked Postsynaptic Currents
Mehta B, Snellman J, Chen S, Li W, Zenisek D. Synaptic Ribbons Influence the Size and Frequency of Miniature-like Evoked Postsynaptic Currents. Neuron 2013, 77: 516-527. PMID: 23395377, PMCID: PMC3569740, DOI: 10.1016/j.neuron.2012.11.024.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAminobutyratesAnimalsBiophysicsCo-Repressor ProteinsDNA-Binding ProteinsDose-Response Relationship, DrugElectric StimulationExcitatory Amino Acid AgonistsExcitatory Postsynaptic PotentialsGABA AntagonistsGlycine AgentsHibernationIn Vitro TechniquesMiceMice, Inbred C57BLPatch-Clamp TechniquesPhosphinic AcidsPhosphoproteinsPicrotoxinPyridinesReceptors, AMPARetinaSciuridaeStrychnineSynapsesVisual PathwaysWakefulnessConceptsSynaptic ribbons
2011
Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming
Snellman J, Mehta B, Babai N, Bartoletti TM, Akmentin W, Francis A, Matthews G, Thoreson W, Zenisek D. Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming. Nature Neuroscience 2011, 14: 1135-1141. PMID: 21785435, PMCID: PMC3171202, DOI: 10.1038/nn.2870.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAnimalsBiophysicsCo-Repressor ProteinsDNA-Binding ProteinsElectric StimulationExcitatory Postsynaptic PotentialsExocytosisIn Vitro TechniquesLightMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionPatch-Clamp TechniquesPeptidesPhosphoproteinsProtein BindingRetinaRetinal Bipolar CellsSynapsesSynaptic VesiclesTime FactorsUrodelaDevelopment of new peptide-based tools for studying synaptic ribbon function
Francis AA, Mehta B, Zenisek D. Development of new peptide-based tools for studying synaptic ribbon function. Journal Of Neurophysiology 2011, 106: 1028-1037. PMID: 21653726, PMCID: PMC3154815, DOI: 10.1152/jn.00255.2011.Peer-Reviewed Original Research
2000
The Role of Mitochondria in Presynaptic Calcium Handling at a Ribbon Synapse
Zenisek D, Matthews G. The Role of Mitochondria in Presynaptic Calcium Handling at a Ribbon Synapse. Neuron 2000, 25: 229-237. PMID: 10707986, DOI: 10.1016/s0896-6273(00)80885-5.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCalcium-Transporting ATPasesCarbonyl Cyanide m-Chlorophenyl HydrazoneFluorescent DyesFura-2GoldfishLanthanumMembrane PotentialsMitochondriaPatch-Clamp TechniquesPotassiumRetinaRhodamine 123SodiumSynapsesSynaptic TransmissionUncoupling AgentsVision, OcularConceptsSynaptic terminalsCalcium handlingBipolar cell synaptic terminalsCalcium clearance mechanismsRetinal bipolar neuronsSingle synaptic terminalsClearance of Ca2Patch-clamp techniqueATP-dependent Ca2Bipolar neuronsRibbon synapseClamp techniqueClearance mechanismsCalcium uptakeLarge Ca2Role of mitochondriaMitochondrial uptakeCa2Mitochondria actMembrane extrusionNeuronsUptake
1998
Calcium action potentials in retinal bipolar neurons
ZENISEK D, MATTHEWS G. Calcium action potentials in retinal bipolar neurons. Visual Neuroscience 1998, 15: 69-75. PMID: 9456506, DOI: 10.1017/s0952523898151064.Peer-Reviewed Original ResearchConceptsBipolar neuronsSynaptic terminalsAction potentialsCalcium-dependent action potentialsCalcium channel blockersRetinal bipolar neuronsCalcium action potentialsPerforated-patch recordingsNeurotransmitter GABAIntracellular calciumGoldfish retinaIntraterminal calciumCalcium channelsCalcium transientsRegenerative depolarizationTransient increaseNeuronsElectrical excitabilityFish retinaCalcium actionSpontaneous increaseRetinaElectrical recordingsExternal applicationCalcium
1997
Static and Dynamic Membrane Properties of Large-Terminal Bipolar Cells From Goldfish Retina: Experimental Test of a Compartment Model
Mennerick S, Zenisek D, Matthews G. Static and Dynamic Membrane Properties of Large-Terminal Bipolar Cells From Goldfish Retina: Experimental Test of a Compartment Model. Journal Of Neurophysiology 1997, 78: 51-62. PMID: 9242260, DOI: 10.1152/jn.1997.78.1.51.Peer-Reviewed Original ResearchConceptsBipolar neuronsGoldfish retinaSynaptic terminalsBipolar cellsIntact goldfish retinaDepolarization-evoked increaseSingle synaptic terminalsSynaptic transmitter releaseWhole-cell recordingsSoma/dendritesMorphological correlatesElectrotonic architectureTwo-compartment modelTransmitter releaseBiexponential time courseCell recordingsPatch pipetteNeuronsCompartment modelRetinaLines of evidenceTime courseSomaCells