1989
Effect of varying drop size on the efficacy and safety of a topical beta blocker.
Charap A, Shin D, Petursson G, Cinotti D, Wortham E, Brown R, Silverstone D, Atkins J, Eto C, Lue J. Effect of varying drop size on the efficacy and safety of a topical beta blocker. Annals Of Ophthalmology - Glaucoma 1989, 21: 351-7. PMID: 2683937.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAdultBlood PressureDosage FormsDose-Response Relationship, DrugDouble-Blind MethodElectrocardiographyExercise TestFollow-Up StudiesGlaucoma, Open-AngleHeart RateHumansIntraocular PressureLevobunololMiddle AgedMulticenter Studies as TopicRandom AllocationTime FactorsVisual AcuityConceptsIntraocular pressureBeta blockersHeart rateMicroL of vehicleTopical beta blockersMean intraocular pressureElevated intraocular pressureMean heart rateLevobunolol 0.5Levobunolol groupBlood pressureAcute studyTopical solutionVehicle groupChronic studiesMean decreaseControl groupOne hourEfficacyLevobunololBlockersSafetyGroupMicroLPatients
1985
Levobunolol A Beta-adrenoceptor Antagonist Effective in the Long-term Treatment of Glaucoma
Group T, Berson F, Epstein D, Partamian L, Cinotti A, Cohen H, Fries P, David R, Gurion B, Duzman E, Novack G, Lue J, Foerster R, Galin M, Lass J, Ober M, Scharrer A, Shin D, Silverstone D. Levobunolol A Beta-adrenoceptor Antagonist Effective in the Long-term Treatment of Glaucoma. Ophthalmology 1985, 92: 1271-1276. PMID: 2865710, DOI: 10.1016/s0161-6420(85)33887-3.Peer-Reviewed Original ResearchConceptsLong-term treatmentDouble-masked studyOcular hypotensive efficacyOcular hypotensive effectOpen-angle glaucomaMean heart rateConcentrations of levobunololTest medicationOcular hypertensionBlood pressureMean IOPSystemic reactionsOcular safetyEffective therapyHeart rateOphthalmic solutionGlaucomaLevobunololPatientsTwo-year periodTimololTreatmentHypertensionMedicationsIOP