1998
Alternative splicing of rearranged T cell receptor δ sequences to the constant region of the α locus
Livák F, Schatz D. Alternative splicing of rearranged T cell receptor δ sequences to the constant region of the α locus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 5694-5699. PMID: 9576946, PMCID: PMC20441, DOI: 10.1073/pnas.95.10.5694.Peer-Reviewed Original ResearchConceptsCalpha geneTCRalpha/delta locusT cell receptor alpha/delta locusDelta locusAlpha/delta locusProtein coding capacityTranscriptional controlAlternative splicingSplicing variationsDistinct functional capacitiesAlternative transcriptsDelta proteinΑ locusChimeric proteinConstant genesAlpha proteinGene-deficient miceCoding capacityGenesThymocyte developmentAlphabeta thymocytesNovel insightsTCRbeta chainLociDistinct diversity
1996
T-Cell Receptor α Locus V(D)J Recombination By-Products Are Abundant in Thymocytes and Mature T Cells
Livak F, Schatz D. T-Cell Receptor α Locus V(D)J Recombination By-Products Are Abundant in Thymocytes and Mature T Cells. Molecular And Cellular Biology 1996, 16: 609-618. PMID: 8552089, PMCID: PMC231040, DOI: 10.1128/mcb.16.2.609.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA DamageGene Rearrangement, alpha-Chain T-Cell Antigen ReceptorImmune SystemMiceMice, Inbred C57BLMolecular Probe TechniquesMolecular Sequence DataReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRecombination, GeneticThymus GlandT-LymphocytesConceptsRecombination signal sequencesSignal sequenceDNA moleculesAlpha locusTCR alpha/delta locusAlpha/delta locusBroken DNA moleculesReciprocal productsJ alpha locusTermination of expressionT-cell receptor α locusC delta regionTCR alpha locusSouthern blot analysisT cell developmentGenome integrityDNA existΑ locusQuantitative Southern blot analysisT-cell receptor genesCoding regionsDevelopmental transitionsLymphoid developmentDelta locusRAG-2