2024
Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for the treatment of head and neck oropharyngeal carcinoma (OPC).
Frank S, Busse P, Rosenthal D, Hernandez M, Swanson D, Garden A, Sturgis E, Ferrarotto R, Gunn G, Patel S, LEE N, Lin A, Snider J, McDonald M, Henson C, Bajaj G, Kalman N, Parvathaneni U, Katz S, Foote R. Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for the treatment of head and neck oropharyngeal carcinoma (OPC). Journal Of Clinical Oncology 2024, 42: 6006-6006. DOI: 10.1200/jco.2024.42.16_suppl.6006.Peer-Reviewed Original ResearchProgression-free survivalProgression-free survival HROverall survivalOropharyngeal carcinomaInduction chemotherapyChemoradiation therapyGastrostomy-tube dependenceHazard ratioRate of progression-free survivalManagement of head and neck tumorsIntensity-modulated photon therapyReceipt of induction chemotherapyTreated with chemoradiation therapyIntensity-modulated proton therapySurgical lymph node dissectionHead and neck tumorsPhase III randomized trialWeight loss <5%Bilateral neck treatmentHuman papillomavirus statusLymph node dissectionTarget tumor volumeMedian follow-upDe-intensification strategiesIntent-to-treatAcupuncture for Chronic Radiation-Induced Xerostomia in Head and Neck Cancer
Cohen L, Danhauer S, Garcia M, Dressler E, Rosenthal D, Chambers M, Cusimano A, Brown W, Ochoa J, Yang P, Chiang J, Gordon O, Crutcher R, Kim J, Russin M, Lukenbill J, Porosnicu M, Yost K, Weaver K, Lesser G. Acupuncture for Chronic Radiation-Induced Xerostomia in Head and Neck Cancer. JAMA Network Open 2024, 7: e2410421. PMID: 38739392, PMCID: PMC11091764, DOI: 10.1001/jamanetworkopen.2024.10421.Peer-Reviewed Original ResearchConceptsSham acupunctureTrue acupunctureTreating radiation-induced xerostomiaHead and neck cancerFunctional Assessment of Cancer Therapy-General scoresRadiation-induced xerostomiaBenefits of acupunctureQuestionnaire scoresCommunity-based cancer centerNeck cancerPatient-reported outcomesRisk of biasQuality of lifeTreated 2 timesAcupuncture studiesGroup differencesStatistically significant group differencesBetween-group differencesAcupunctureXerostomia questionnaire scoreMain OutcomesSignificant group differencesFunctional assessmentStudy armsCancer CenterSurrogate Endpoints in p16-Positive Squamous Cell Carcinoma of the Oropharynx
Gharzai L, Morris E, Nguyen-Tan P, Rosenthal D, Gillison M, Harari P, Garden A, Zanotti K, Caudell J, Jones C, Mitchell D, Krempl G, Ridge J, Gensheimer M, Bonner J, Le Q, Torres-Saavedra P, Mierzwa M, Schipper M. Surrogate Endpoints in p16-Positive Squamous Cell Carcinoma of the Oropharynx. International Journal Of Radiation Oncology • Biology • Physics 2024, 118: e14. DOI: 10.1016/j.ijrobp.2024.01.035.Peer-Reviewed Original ResearchLocoregional progression-free survivalProgression-free survivalP16-positive oropharyngeal cancerOverall survivalOropharyngeal cancerIncreasing incidence of HPV-related cancersIncidence of HPV-related cancersP16-positive squamous cell carcinomaOptimal treatment paradigmMedian follow-upHPV-related cancersSquamous cell carcinomaMulticenter randomized trialClinical trial endpointsLocoregional progressionDistant metastasisLocal progressionCell carcinomaDefinitive treatmentTreatment paradigmDMFSFollow-upRandomized trialsIncreased incidenceTreatment effectsLongitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study
Koutroumpakis E, Mohamed A, Chaftari P, Rosenthal D, Gujral D, Nutting C, Kamel S, Naser M, Kim P, Bassett R, Fuller C, Mouhayar E, Group A. Longitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study. Radiotherapy And Oncology 2024, 195: 110220. PMID: 38467343, DOI: 10.1016/j.radonc.2024.110220.Peer-Reviewed Original ResearchIntima-media thicknessGlobal circumferential strainRadiation therapyCarotid arteryHead and neck RTHead and neck cancer patientsHead and neck cancerNeck radiation therapyCircumferential strainNeck cancer patientsCarotid intima-media thicknessCarotid artery injuryArtery duplex studiesCarotid artery stenosisNeck RTNo significant differenceNeck cancerDuplex studiesArterial injuryArtery stenosisCancer patientsMedia thicknessCarotid ultrasoundArterial elastanceCarotidMR-guided stereotactic radiation therapy for head and neck cancers
Wang H, Yang J, Lee A, Phan J, Lim T, Fuller C, Han E, Rhee D, Salzillo T, Zhao Y, Chopra N, Pham M, Castillo P, Sobremonte A, Moreno A, Reddy J, Rosenthal D, Garden A, Wang X. MR-guided stereotactic radiation therapy for head and neck cancers. Clinical And Translational Radiation Oncology 2024, 46: 100760. PMID: 38510980, PMCID: PMC10950743, DOI: 10.1016/j.ctro.2024.100760.Peer-Reviewed Original ResearchAdapt-to-shapeStereotactic body radiation therapyIMRT plansVMAT plansTarget coverageMR-LinacPlan qualityAdapt-to-shape workflowElekta Unity MR-linacMonaco treatment planning systemSoft tissue contrastVMAT treatment plansTreatment planning systemUnity MR-linacCritical organ dosesMR-guided radiotherapyHead and neckAdapt-to-positionRadiation therapyMean doseVarian TrueBeamTrueBeam STxOAR dosesDosimetric differencesElekta UnityDyadic Yoga for Head and Neck Cancer Patients Undergoing Chemoradiation and their Family Caregivers
Milbury K, Rosenthal D, Li Y, Ngo-Huang A, Mallaiah S, Yousuf S, Fuller C, Lewis C, Bruera E, Cohen L. Dyadic Yoga for Head and Neck Cancer Patients Undergoing Chemoradiation and their Family Caregivers. Journal Of Pain And Symptom Management 2024, 67: 490-500. PMID: 38447621, DOI: 10.1016/j.jpainsymman.2024.02.565.Peer-Reviewed Original ResearchEmergency department visitsHead and neck cancerWaitlist controlHead and neck cancer patientsFamily caregiversYoga groupDepartment visitsYoga therapyHospital admissionPatient emergency department visitsPatient's last daysActive study participantsUnplanned hospital admissionsFeeding tube placementWaitlist control groupSupportive care strategiesQuality of lifeDyadic yogaYoga interventionYoga programCaregiver efficacyPilot RCTSF-36Care strategiesSymptom interferenceSurrogate endpoints in clinical trials of p16-positive squamous cell carcinoma of the oropharynx: an individual patient data meta-analysis
Gharzai L, Morris E, Suresh K, Nguyen-Tân P, Rosenthal D, Gillison M, Harari P, Garden A, Koyfman S, Caudell J, Jones C, Mitchell D, Krempl G, Ridge J, Gensheimer M, Bonner J, Filion E, Dunlap N, Stokes W, Le Q, Torres-Saavedra P, Mierzwa M, Schipper M. Surrogate endpoints in clinical trials of p16-positive squamous cell carcinoma of the oropharynx: an individual patient data meta-analysis. The Lancet Oncology 2024, 25: 366-375. PMID: 38423050, PMCID: PMC10962533, DOI: 10.1016/s1470-2045(24)00016-0.Peer-Reviewed Original ResearchConceptsLocoregional progression-free survivalProgression-free survivalIntermediate clinical endpointsMetastasis-free survivalOverall survivalClinical endpointsOropharyngeal cancerComposite endpointIncidence of human papillomavirus (HPV)-related cancersP16-positive squamous cell carcinomaHuman papillomavirus (HPV)-related cancersP16-positive oropharyngeal cancerCancer treated with chemotherapyIndividual patient data meta-analysisMedian follow-upPatient data meta-analysisSquamous-cell carcinomaSquamous cell carcinomaPatient levelClinical trial endpointsTreatment effectsData meta-analysisLocoregional progressionNational Cancer InstituteDistant metastasisClinical acceptability of automatically generated lymph node levels and structures of deglutition and mastication for head and neck radiation therapy
Maroongroge S, Mohamed A, Nguyen C, De la Vega J, Frank S, Garden A, Gunn B, Lee A, Mayo L, Moreno A, Morrison W, Phan J, Spiotto M, Court L, Fuller C, Rosenthal D, Netherton T. Clinical acceptability of automatically generated lymph node levels and structures of deglutition and mastication for head and neck radiation therapy. Physics And Imaging In Radiation Oncology 2024, 29: 100540. PMID: 38356692, PMCID: PMC10864833, DOI: 10.1016/j.phro.2024.100540.Peer-Reviewed Original ResearchLymph node levelsAI contoursClinical acceptanceSwallowing structuresComputed tomographyHead and neck radiotherapy patientsHead and neckMedian Dice similarity coefficientLevels I-VDice similarity coefficientRadiotherapy patientsCT scanManual contouringLymphComplex anatomyCT imagesCohortI-VPatientsChewingSimilarity coefficientAnatomyRadiotherapyHeadNode level
2023
Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation
Mohamed A, Martin G, Ng S, Takiar V, Beadle B, Zafereo M, Garden A, Frank S, Fuller C, Gunn G, Morrison W, Rosenthal D, Reddy J, Moreno A, Lee A, Phan J. Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation. Clinical And Translational Radiation Oncology 2023, 44: 100700. PMID: 38058404, PMCID: PMC10695834, DOI: 10.1016/j.ctro.2023.100700.Peer-Reviewed Original ResearchLocoregional recurrenceSalvage surgeryRecurrent headNeck squamous cell cancerNeck squamous cell carcinomaPhysician's classificationMarginal failureSubsequent locoregional recurrenceSquamous cell cancerSquamous cell carcinomaPatterns of failureLogistic regression analysisDeformable image registrationAdjuvant reirradiationRadiological progressionSurgical salvageInitial recurrenceRecurrent diseaseSalvage rateRecurrent HNSCCCell cancerMucosal sitesCell carcinoma137 Stereotactic Boost and Short-Course Radiotherapy for P16-Associated Oropharynx Cancer (Short-Opc): First Planned Interim Safety Analysis from a Randomized Phase Ii Trial
Ng S, Fuller D, Garden A, Rosenthal D, Phan J, Nguyen-Tan P, Yuan Y, Filion E, Soulieres D, Christopoulos A, Hutcheson K, Lee A, Bahig H. 137 Stereotactic Boost and Short-Course Radiotherapy for P16-Associated Oropharynx Cancer (Short-Opc): First Planned Interim Safety Analysis from a Randomized Phase Ii Trial. Radiotherapy And Oncology 2023, 186: s63. DOI: 10.1016/s0167-8140(23)89228-3.Peer-Reviewed Original Research
2022
Primary Care for Veterans Experiencing Homelessness: a Narrative Review of the Homeless Patient Aligned Care Team (HPACT) Model
Tsai J, Havlik J, Howell B, Johnson E, Rosenthal D. Primary Care for Veterans Experiencing Homelessness: a Narrative Review of the Homeless Patient Aligned Care Team (HPACT) Model. Journal Of General Internal Medicine 2022, 38: 765-783. PMID: 36443628, PMCID: PMC9971390, DOI: 10.1007/s11606-022-07970-y.Peer-Reviewed Original ResearchConceptsHomeless Patient Aligned Care TeamPrimary care medical home modelsVeterans' healthOnly original research studiesNarrative reviewPatient Aligned Care TeamsCare team modelPrimary care utilizationEmergency department utilizationMedical home modelDatabases Ovid MEDLINEPositive patient experienceVeterans Experiencing HomelessnessOriginal research studiesCare utilizationOvid EmbasePrimary careCare teamOvid MEDLINEInclusion criteriaPatient experiencePeer-reviewed studiesHome modelHealthcare outcomesVA system
2021
Tips for Building a Community for Incoming Medical Students Virtually in the COVID-19 Era
Zheng M, Ruzgar NM, Angoff NR, Rosenthal DI. Tips for Building a Community for Incoming Medical Students Virtually in the COVID-19 Era. Medical Science Educator 2021, 31: 2033-2040. PMID: 34754599, PMCID: PMC8567972, DOI: 10.1007/s40670-021-01447-z.Peer-Reviewed Original ResearchCOVID-19 eraNew learning environmentMedical school communityIncoming medical studentsSense of communityLearning environmentSchool communitySchool institutionsClass formatMedical schoolsMedical studentsMedical traineesStudentsAccompanying shiftSupport relationshipsSchoolsMatriculationCollegialityCurrent pandemicMentorshipCommunityAn Advanced Communication Skills Workshop Using Standardized Patients for Senior Medical Students
Talwalkar JS, Fortin AH, Morrison LJ, Kliger A, Rosenthal DI, Murtha T, Ellman MS. An Advanced Communication Skills Workshop Using Standardized Patients for Senior Medical Students. MedEdPORTAL 2021, 17: 11163. PMID: 34124349, PMCID: PMC8155077, DOI: 10.15766/mep_2374-8265.11163.Peer-Reviewed Original Research
2019
Six habits of highly successful health information technology: powerful strategies for design and implementation
Ray JM, Ratwani RM, Sinsky CA, Frankel RM, Friedberg MW, Powsner SM, Rosenthal DI, Wachter RM, Melnick ER. Six habits of highly successful health information technology: powerful strategies for design and implementation. Journal Of The American Medical Informatics Association 2019, 26: 1109-1114. PMID: 31265064, PMCID: PMC7647223, DOI: 10.1093/jamia/ocz098.Peer-Reviewed Original ResearchConceptsInformation technologyHealthcare information technologyHealth information technologyEnd usersUsable technologyHealthcare technologiesPatient-clinician interactionsPatient-clinician relationshipCentre of careOperational functionsDocumentation burdenUse of scribesTechnologyPatient careRegulatory complianceRoutine componentClinical operationsDevelopersUsersHealth technologiesRight skillsCareBillingEveryday lifeImplementation
2016
Meaning and the Nature of Physicians’ Work
Rosenthal DI, Verghese A. Meaning and the Nature of Physicians’ Work. New England Journal Of Medicine 2016, 375: 1813-1815. PMID: 27959650, DOI: 10.1056/nejmp1609055.Peer-Reviewed Original Research
2015
A mobile app for securely capturing and transferring clinical images to the electronic health record: description and preliminary usability study.
Landman A, Emani S, Carlile N, Rosenthal DI, Semakov S, Pallin DJ, Poon EG. A mobile app for securely capturing and transferring clinical images to the electronic health record: description and preliminary usability study. JMIR MHealth And UHealth 2015, 3: e1. PMID: 25565678, PMCID: PMC4296096, DOI: 10.2196/mhealth.3481.Peer-Reviewed Original Research
2013
Instant replay
Rosenthal DI. Instant replay. Healthcare 2013, 1: 52-54. PMID: 26249640, DOI: 10.1016/j.hjdsi.2013.04.004.Peer-Reviewed Original ResearchElectronic health recordsData captureCurrent electronic health recordsCurrent EHR systemsSignificant data lossClinical documentation systemData lossEHR systemsElectronic clinical documentationInstant replayHealth recordsGreat facultyDocumentation systemWidespread adoptionClinical notesVideo recordsClinical documentationMultiple pointsReplay
2011
- Rosenthal DI, Hauser J. In The Picture of Health: Medical Ethics and the Movies, ed H Colt, S Quadrelli. Oxford University Press, May 2011, pp.433-440. http://www.oxfordscholarship.com/view/10.1093/acprof:osobl/9780199735365.001.0001/acprof-9780199735365-chapter-73Peer-Reviewed Original Research