Multicenter Phase III Trial of Chemoradiation (CRT) with IMPT vs. IMRT for Oropharyngeal Squamous Cell Carcinoma (OPSCC): Secondary Analysis of Association of Lymphopenia with Treatment Modality, Emergency Room (ER) Visits and Hospital Admission (HA)
Grippin A, Foote R, Busse P, Rosenthal D, Hernandez M, Garden A, Sturgis E, Ferrarotto R, Gunn G, Patel S, Lee N, Lin A, Snider J, McDonald M, Henson C, Bajaj G, Kalman N, Parvathaneni U, Frank S. Multicenter Phase III Trial of Chemoradiation (CRT) with IMPT vs. IMRT for Oropharyngeal Squamous Cell Carcinoma (OPSCC): Secondary Analysis of Association of Lymphopenia with Treatment Modality, Emergency Room (ER) Visits and Hospital Admission (HA). International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e755. DOI: 10.1016/j.ijrobp.2024.07.1658.Peer-Reviewed Original ResearchIntensity modulated proton therapyOropharyngeal squamous cell carcinomaAbsolute lymphocyte countAbsolute lymphocyte count nadirBaseline absolute lymphocyte countGrade 4 lymphopeniaMultivariate analysisTreatment modalitiesHospital admissionAdvanced stage oropharyngeal squamous cell carcinomaStage oropharyngeal squamous cell carcinomaMulticenter phase III trialPhase III randomized controlled trialsEmergency roomPhase III non-inferiority trialAssociation of lymphopeniaBilateral neck radiationBody mean doseStage III-IVAEffectiveness of treatment modalitiesSquamous cell carcinomaAssociated with increased ratesClinical implicationsER visitsSecondary analysis