Role of “Western Diet” in Inflammatory Autoimmune Diseases
Manzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M. Role of “Western Diet” in Inflammatory Autoimmune Diseases. Current Allergy And Asthma Reports 2013, 14: 404. PMID: 24338487, PMCID: PMC4034518, DOI: 10.1007/s11882-013-0404-6.Peer-Reviewed Original ResearchConceptsAutoimmune diseasesWestern dietInflammatory autoimmune diseaseExcess salt intakeImmunologic mechanismsMetabolic syndromeSalt intakeAutoimmune pathologyCardiovascular diseaseT cellsWesternized countriesFrequent consumptionDietary influencesInfectious diseasesDiseaseNutritional patternsFast foodPathogen exposureDietCurrent knowledgeCentral playerAutoimmunityObesitySyndromeCholesterolMicrobial Reprogramming Inhibits Western Diet-Associated Obesity
Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney SM, Chatzigiagkos A, Hafler DA, Alm EJ, Erdman SE. Microbial Reprogramming Inhibits Western Diet-Associated Obesity. PLOS ONE 2013, 8: e68596. PMID: 23874682, PMCID: PMC3707834, DOI: 10.1371/journal.pone.0068596.Peer-Reviewed Original ResearchConceptsAge-associated weight gainWeight gainT cellsFast foodAd libitum caloric intakeActive immune toleranceImmune cell profilesRegulatory T cellsT cell balanceRecent epidemiological studiesLikelihood of obesityNaïve recipient animalsGut microbial ecologyT helperImmune toleranceBaseline dietWeight managementCaloric intakePopulation-based approachMouse modelCell balanceEpidemiological studiesRecipient animalsAnimal modelsAbdominal fat