Comparative Analysis of Fecal Microbiota Between Adolescents with Early-Onset Psychosis and Adults with Schizophrenia
Nuncio-Mora L, Nicolini H, Lanzagorta N, García-Jaimes C, Sosa-Hernández F, González-Covarrubias V, Cabello-Rangel H, Sarmiento E, Glahn D, Genis-Mendoza A. Comparative Analysis of Fecal Microbiota Between Adolescents with Early-Onset Psychosis and Adults with Schizophrenia. Microorganisms 2024, 12: 2071. PMID: 39458380, PMCID: PMC11510430, DOI: 10.3390/microorganisms12102071.Peer-Reviewed Original ResearchEarly-onset psychosisPsychiatric disordersAtypical antipsychotic treatmentNon-psychotic individualsTreated with sertralineAntipsychotic treatmentSchizophrenia groupSchizophrenia patientsSchizophreniaGut-brain axisPsychosisGene orthology analysisPotential metabolic functionsAssociated with gut dysbiosisFunctional prediction analysisValproate treatmentPharmacological treatmentOscillospiraceae familiesOrthology analysisDecreased levelsFatty acid metabolismGut microbiomeExpressed genesMicrobial communitiesMicrobial compositionRESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS
Kochunov P, Nichols T, Blangero J, Medland S, Glahn D, Hong E. RESOLVING THE CHALLENGES OF BIG-DATA IMAGING GENETICS ANALYSIS TO UNDERSTAND GENETIC AND ENVIRONMENTAL RISK FACTORS IN PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2024, 87: 21-22. DOI: 10.1016/j.euroneuro.2024.08.056.Peer-Reviewed Original ResearchGenetic analysisGenome-wide associationBrain patternsImaging genetic analysisImaging genetic datasetGenetic resolutionGenetic risk factorsGenetic datasetsGenetic dataDepressive disorderPsychiatric disordersRisk of development of dementiaVariance componentsHigh-resolution neuroimagingDevelopment of dementiaNurturing interactionsEnvironmental risk factorsAlzheimer's diseaseGenetic correlationsRisk factorsTreatment effectsDisordersLongitudinal datasetPsychosisSNPsCharacterization of pain and somatization and its relationship with psychopathology in early onset psychosis
van der Heijden H, Goldman M, Ray A, Golden E, Petty C, Deaso E, Hojlo M, Sethna N, Glahn D, Gonzalez-Heydrich J, Upadhyay J. Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis. Journal Of Psychiatric Research 2024, 179: 77-82. PMID: 39260111, PMCID: PMC11531992, DOI: 10.1016/j.jpsychires.2024.09.006.Peer-Reviewed Original ResearchBrief Psychiatric Rating ScaleEarly onset psychosisDegree of psychopathologyBrief Psychiatric Rating Scale totalBrief Psychiatric Rating Scale subscalesDimensions of psychopathologyPsychiatric Rating ScaleChlorpromazine equivalent doseAntipsychotic medication usageControl of psychosisStructured Clinical InterviewAdult-onset psychosisPain catastrophizingSelf-report questionnairesCentral sensitizationPain severityFrequent cause of distressClinical interviewSomatic severityClinical presentation of painSomatic symptomsPsychopathologyPsychosisSubscale scoresRating Scale