Hypertensive disorders during pregnancy and polycystic ovary syndrome are associated with child communication and social skills in a sex-specific and androgen-dependent manner
Firestein MR, Romeo RD, Winstead H, Goldman DA, Grobman WA, Haas DM, Parry S, Reddy UM, Silver RM, Wapner RJ, Champagne FA. Hypertensive disorders during pregnancy and polycystic ovary syndrome are associated with child communication and social skills in a sex-specific and androgen-dependent manner. Frontiers In Endocrinology 2022, 13: 1000732. PMID: 36246897, PMCID: PMC9559211, DOI: 10.3389/fendo.2022.1000732.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeHyperandrogenic disordersOvary syndromeMaternal testosteroneHypertensive disordersNulliparous Pregnancy Outcomes StudyCohort study designPregnancy Outcomes StudyYears of ageAutism spectrum disorderSex-specific associationsHigher testosterone levelsChildren's brain developmentNeurodevelopmental outcomesAndrogen-dependent mannerSecond trimesterPrenatal exposureMonitoring MothersTestosterone levelsOutcome studiesPregnancyFemale controlsMaternal plasmaTestosteroneChild communication