2006
Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages
Tircol M, Tirziu D, Simionescu M. Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages. Open Life Sciences 2006, 1: 150-166. DOI: 10.2478/s11535-006-0010-x.Peer-Reviewed Original ResearchSmooth muscle cellsLipid accumulationMuscle cellsHuman aortic smooth muscle cellsCultured smooth muscle cellsAortic smooth muscle cellsGene expressionLysosomal degradationLDL receptorCellular degradationMatrix proteinsAcidic compartmentsCellular uptakeLysosomal compartmentCell typesFluorescence microscopyLDL inducesUndegraded formCholesterol ester synthesisRT-PCRCholesteryl ester synthesisNative LDLAccumulationRegulationRegulation of LDL
1993
Pathobiochemical Changes of the Arterial Wall at the Inception of Atherosclerosis
Simionescu N, Sima A, Dobrian A, Tirziu D, Simionescu M. Pathobiochemical Changes of the Arterial Wall at the Inception of Atherosclerosis. Current Topics In Pathology 1993, 87: 1-45. PMID: 8125021, DOI: 10.1007/978-3-642-76849-1_1.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinPotential therapeutic implicationsCerebral infarctionSerum cholesterolLipid infiltrationLDL metabolismPathogenic factorsPathobiochemical changesTherapeutic implicationsAtherosclerosisLDL receptorArterial wallArtery wallCardiovascular researchMolecular mechanismsMultiplicity of factorsCellular eventsLines of investigationInfarctionAtherogenesisPathogenesis