2006
Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages
Tircol M, Tirziu D, Simionescu M. Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages. Open Life Sciences 2006, 1: 150-166. DOI: 10.2478/s11535-006-0010-x.Peer-Reviewed Original ResearchSmooth muscle cellsLipid accumulationMuscle cellsHuman aortic smooth muscle cellsCultured smooth muscle cellsAortic smooth muscle cellsGene expressionLysosomal degradationLDL receptorCellular degradationMatrix proteinsAcidic compartmentsCellular uptakeLysosomal compartmentCell typesFluorescence microscopyLDL inducesUndegraded formCholesterol ester synthesisRT-PCRCholesteryl ester synthesisNative LDLAccumulationRegulationRegulation of LDL
2005
Angiogenesis in the human heart: Gene and cell therapy
Tirziu D, Simons M. Angiogenesis in the human heart: Gene and cell therapy. Angiogenesis 2005, 8: 241-251. PMID: 16308736, DOI: 10.1007/s10456-005-9011-z.Peer-Reviewed Original ResearchConceptsNew vessel growthCell therapyPeripheral arterial diseaseVessel growthBest cell typeStimulation of angiogenesisMechanism of actionArterial diseasePatient selectionClinical trialsBlood supplyIschemic tissueIschemic diseasesNew therapiesTherapyGrowth factorHuman heartDiseaseCell typesAngiogenesisMain biological processesPatientsMultiple questionsTrials