Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance
Shukla S, Cyrta J, Murphy DA, Walczak EG, Ran L, Agrawal P, Xie Y, Chen Y, Wang S, Zhan Y, Li D, Wong EWP, Sboner A, Beltran H, Mosquera JM, Sher J, Cao Z, Wongvipat J, Koche RP, Gopalan A, Zheng D, Rubin MA, Scher HI, Chi P, Chen Y. Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer Cell 2017, 32: 792-806.e7. PMID: 29153843, PMCID: PMC5728174, DOI: 10.1016/j.ccell.2017.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 1-alphaHepatocyte Nuclear Factor 4HeterograftsHumansMaleMiceMice, SCIDProstatic Neoplasms, Castration-ResistantTrypsin Inhibitor, Kazal PancreaticConceptsProstate cancerCastration resistanceHNF4GCastration-resistant prostate cancerAndrogen deprivation therapyAndrogen receptor signalingPrimary prostate cancerAndrogen requirementAndrogen signalingPhysiologic levelsCancerAberrant activationExogenous expressionActivationSignalingAlternative lineage programsAndrogensTherapy