2024
RNA Interference-based Therapies for the Reduction of Cardiovascular Risk
Nazarenko N, Seo J, Nagraj S, Palaiodimos L, Kokkinidis D. RNA Interference-based Therapies for the Reduction of Cardiovascular Risk. Current Molecular Pharmacology 2024, 17: e18761429264553. PMID: 38449067, DOI: 10.2174/0118761429264553231204115314.Peer-Reviewed Original ResearchLDL-C levelsLDL-CReduction of cardiovascular riskRNA interference-based therapiesSignificant cardiovascular eventsLDL-C level reductionRisk of cardiovascular diseaseCases of coronary artery diseaseNon-modifiable risk factorsCoronary artery diseasePrevalent risk factorIncidence of CVDLowering lipid levelsRisk factors of heart diseaseCardiovascular eventsFactors of heart diseaseMortality benefitCardiovascular riskArtery diseaseRisk factorsHeart diseaseLipid levelsCardiovascular diseasePrevent 2Lifestyle factorsHypertension Management in Peripheral Artery Disease: A Mini Review
Kharawala A, Nagraj S, Pargaonkar S, Seo J, Kokkinidis D, Altin S. Hypertension Management in Peripheral Artery Disease: A Mini Review. Current Hypertension Reviews 2024, 20: 1-9. PMID: 38083897, DOI: 10.2174/0115734021267004231122061712.Peer-Reviewed Original ResearchPeripheral artery diseaseAngiotensin receptor blockersHypertension managementArtery diseaseAmerican Heart Association/American CollegeDevelopment of PADLower extremity peripheral artery diseaseConcomitant peripheral artery diseaseLower blood pressure levelsBlood pressure targetsGuideline-directed therapyUse of angiotensinLarge randomized trialsBlood pressure levelsTreatment of hypertensionMajor risk factorComplex patient populationWorse health outcomesPost Hoc AnalysisAntihypertensive medicationsHypertensive patientsReceptor blockersPressure targetsRandomized trialsAdequate therapy
2023
Inflammation, anti-inflammatory agents, and the role of colchicine in carotid artery stenosis.
Chlorogiannis D, Pargaonkar S, Papanagiotou P, Bakogiannis N, Bakoyiannis C, Kokkinidis D. Inflammation, anti-inflammatory agents, and the role of colchicine in carotid artery stenosis. Vasa 2023, 53: 4-12. PMID: 38079179, DOI: 10.1024/0301-1526/a001104.Peer-Reviewed Original ResearchConceptsCarotid artery stenosisArtery stenosisAnti-inflammatory medicationsRole of inflammationCoronary artery diseaseAnti-inflammatory agentsRole of colchicineArtery diseaseOngoing trialsOptimal treatmentCardiovascular diseaseStenosis developmentMedicationsInflammationAvailable evidenceMajor causeStenosisDiseaseColchicineMorbidityPatientsMortalityProgressionTrialsDifferences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions
Kokkinidis D, Schizas D, Pargaonkar S, Karamanis D, Mylonas K, Hasemaki N, Palaiodimos L, Varrias D, Tzavellas G, Siasos G, Klonaris C, Kharawala A, Chlorogiannis D, Georgopoulos S, Bakoyiannis C. Differences between Lower Extremity Arterial Occlusion vs. Stenosis and Predictors of Successful Endovascular Interventions. Medicina 2023, 59: 2029. PMID: 38004078, PMCID: PMC10673017, DOI: 10.3390/medicina59112029.Peer-Reviewed Original ResearchConceptsChronic total occlusionHistory of malignancyCTO groupRevascularization proceduresSuccessful revascularizationLower extremity chronic total occlusionChronic limb-threatening ischemiaEnd-stage renal diseaseSuccessful endovascular interventionUse of aspirinBaseline clinical variablesLimb-threatening ischemiaPeripheral artery diseaseNegative predictorHigh disease burdenInterventional characteristicsAngiographic characteristicsAspirin useCTO patientsEndovascular revascularizationPositive predictorArtery diseaseStenosis patientsRenal diseaseVascular centers