Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease
Baker C, Lu Z, Zaitsev I, Manuelidis L. Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease. Journal Of Virology 1999, 73: 5089-5097. PMID: 10233972, PMCID: PMC112554, DOI: 10.1128/jvi.73.6.5089-5097.1999.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCathepsinsCreutzfeldt-Jakob SyndromeCricetinaeDisease Models, AnimalGlial Fibrillary Acidic ProteinGuinea PigsMiceMicrogliaPrionsRatsReceptors, CCR5RNA, MessengerTransforming Growth Factor betaConceptsCreutzfeldt-Jakob diseaseLysosomal protease cathepsin SCathepsin SMRNA expressionAbnormal PrP formationHost mRNA expressionUpregulation of CCR5Chemokine receptor CCR5Glial cell involvementGrowth factor beta1Microglial transcriptsNeuronal destructionProtease cathepsin SMicroglial activationAmyloid depositionPathogenetic pathwaysReceptor CCR5Cell involvementRodent modelsChronic reservoirDistinctive neuropathologyPleiotropic cytokineTGF-beta1Primary sitePrP pathology