Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles
Baker CA, Martin D, Manuelidis L. Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles. Journal Of Virology 2002, 76: 10905-10913. PMID: 12368333, PMCID: PMC136595, DOI: 10.1128/jvi.76.21.10905-10913.2002.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid beta-PeptidesAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBrainCD40 AntigensChemokine CXCL10Chemokines, CXCCreutzfeldt-Jakob SyndromeGene ExpressionGene Expression ProfilingInterleukin-1Leukocyte Common AntigensLipopolysaccharidesMiceMicrogliaReceptor, Macrophage Colony-Stimulating FactorReceptors, CCR5RNA, MessengerTumor Necrosis Factor-alphaConceptsCreutzfeldt-Jakob diseaseCJD agentInfectious agentsCJD-infected miceB lymphocyte chemoattractantCytokine interleukin-1betaResult of infectionPathological prion proteinBrain cell typesMicroglial studiesMicroglial changesMicroglial markersReverse transcription-PCRAntigen presentationInterleukin-1betaBrain homogenatesMicrogliaPrP levelsBacterial lipopolysaccharideCellular activationPathological PrPActivated cellsBovine spongiformSpongiform encephalopathiesMolecular pathways