New molecular markers of early and progressive CJD brain infection
Lu ZY, Baker CA, Manuelidis L. New molecular markers of early and progressive CJD brain infection. Journal Of Cellular Biochemistry 2004, 93: 644-652. PMID: 15660413, DOI: 10.1002/jcb.20220.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseBrain infectionTransmissible spongiform encephalopathiesHuman Creutzfeldt-Jakob diseaseAccessible peripheral tissuesL-selectin mRNASerum amyloid A3Progressive diseaseInflammatory pathwaysMIP-1alphaMIP-1betaIntracerebral inoculationPeripheral tissuesEarly diagnosisTSE infectionInfectious componentNormal brainTSE strainsInfectious agentsMyeloid cellsSimilar sequential changesImmune systemMouse brainTSE agentsNew molecular markers