Featured Publications
Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease
Baker CA, Manuelidis L. Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 675-679. PMID: 12525699, PMCID: PMC141055, DOI: 10.1073/pnas.0237313100.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseMyeloid cellsUninfected microgliaInflammatory pathwaysMicroglial cellsIFN-gammaInflammatory stimuliMicrogliaInflammatory genesProtein pathologyInfectious agentsPreclinical diagnosisNeurodegenerative diseasesTransmissible spongiformDiseaseBrainPrP amyloidRNA profilesExpression profilesCellsCDNA arraysPrevious studiesInfectionDiagnosisPathology
2004
New molecular markers of early and progressive CJD brain infection
Lu ZY, Baker CA, Manuelidis L. New molecular markers of early and progressive CJD brain infection. Journal Of Cellular Biochemistry 2004, 93: 644-652. PMID: 15660413, DOI: 10.1002/jcb.20220.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseBrain infectionTransmissible spongiform encephalopathiesHuman Creutzfeldt-Jakob diseaseAccessible peripheral tissuesL-selectin mRNASerum amyloid A3Progressive diseaseInflammatory pathwaysMIP-1alphaMIP-1betaIntracerebral inoculationPeripheral tissuesEarly diagnosisTSE infectionInfectious componentNormal brainTSE strainsInfectious agentsMyeloid cellsSimilar sequential changesImmune systemMouse brainTSE agentsNew molecular markersEarly induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease
Baker CA, Lu ZY, Manuelidis L. Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. Journal Of NeuroVirology 2004, 10: 29-40. PMID: 14982726, PMCID: PMC4624297, DOI: 10.1080/13550280490261761.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseCJD agentCJD brainsInterferon-sensitive genesImmune responseForeign infectious agentsHost immune responseAbnormal prion proteinHost defense mechanismsMicroglial responseInflammatory pathwaysClinical signsPure microgliaViral infectionInfectious agentsWhole brainImmune recognitionPersistent virusesInterferon responsePreclinical diagnosisInfectionEarly inductionBrainMicrogliaGene expression profiles
2002
Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles
Baker CA, Martin D, Manuelidis L. Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles. Journal Of Virology 2002, 76: 10905-10913. PMID: 12368333, PMCID: PMC136595, DOI: 10.1128/jvi.76.21.10905-10913.2002.Peer-Reviewed Original ResearchMeSH KeywordsAmyloid beta-PeptidesAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBrainCD40 AntigensChemokine CXCL10Chemokines, CXCCreutzfeldt-Jakob SyndromeGene ExpressionGene Expression ProfilingInterleukin-1Leukocyte Common AntigensLipopolysaccharidesMiceMicrogliaReceptor, Macrophage Colony-Stimulating FactorReceptors, CCR5RNA, MessengerTumor Necrosis Factor-alphaConceptsCreutzfeldt-Jakob diseaseCJD agentInfectious agentsCJD-infected miceB lymphocyte chemoattractantCytokine interleukin-1betaResult of infectionPathological prion proteinBrain cell typesMicroglial studiesMicroglial changesMicroglial markersReverse transcription-PCRAntigen presentationInterleukin-1betaBrain homogenatesMicrogliaPrP levelsBacterial lipopolysaccharideCellular activationPathological PrPActivated cellsBovine spongiformSpongiform encephalopathiesMolecular pathways