2016
The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury
Song L, Papaioannou G, Zhao H, Luderer H, Miller C, Dall’Osso C, Nazarian R, Wagers A, Demay M. The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology 2016, 157: 4066-4075. PMID: 27526034, PMCID: PMC5045513, DOI: 10.1210/en.2016-1474.Peer-Reviewed Original ResearchConceptsVDR KO miceVitamin D receptorWild-type miceKO miceResident macrophagesM-CSFM-CSF gene expressionVitamin D receptor ablationM-CSF-induced proliferationVitamin D receptor knockoutVitamin D receptor statusInflammatory response to injuryMacrophage colony-stimulating factorColony-stimulating factorPeritoneal resident macrophagesRecruitment of macrophagesTissue resident macrophagesRegulation of innateLigand-dependent actionsLiganded vitamin D receptorResponse to injuryCyclin D1 expressionMacrophage self-renewalParabiosis studiesMacrophage defect
2015
Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice
Kolodin D, van Panhuys N, Li C, Magnuson A, Cipolletta D, Miller C, Wagers A, Germain R, Benoist C, Mathis D. Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice. Cell Metabolism 2015, 21: 543-557. PMID: 25863247, PMCID: PMC4747251, DOI: 10.1016/j.cmet.2015.03.005.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueTreg compartmentT cellsAccumulation of regulatory T cellsConventional CD4(+) T cellsCD4(+) T cellsRegulatory T cellsAdipose tissueMHC class II moleculesEpidemic of obesityClass II moleculesAntigen receptor repertoireWeeks of lifeConsequent metabolic abnormalitiesIndolent proliferationsVAT-TregRegulatory TLean miceMetabolic abnormalitiesLocal inflammationLymphoid organsSoluble mediatorsLean individualsMetabolic indicesPhenotypic conversion
2014
Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
Sinha M, Jang Y, Oh J, Khong D, Wu E, Manohar R, Miller C, Regalado S, Loffredo F, Pancoast J, Hirshman M, Lebowitz J, Shadrach J, Cerletti M, Kim M, Serwold T, Goodyear L, Rosner B, Lee R, Wagers A. Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle. Science 2014, 344: 649-652. PMID: 24797481, PMCID: PMC4104429, DOI: 10.1126/science.1251152.Peer-Reviewed Original ResearchConceptsGDF11 levelsSystemic delivery of recombinant proteinsAged miceSkeletal muscleStem cell dysfunctionAged muscle stem cellsDelivery of recombinant proteinsMuscle stem cellsGrowth differentiation factor 11Differentiation factor 11Parabiosis experimentsSystemic deliveryMouse skeletal muscleImpaired regenerationSatellite cellsCell dysfunctionExercise capacityHeterochronic parabiosisYoung bloodStem cellsFactor 11Regenerative functionMiceMuscle agingRejuvenation factorVascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Katsimpardi L, Litterman N, Schein P, Miller C, Loffredo F, Wojtkiewicz G, Chen J, Lee R, Wagers A, Rubin L. Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Science 2014, 344: 630-634. PMID: 24797482, PMCID: PMC4123747, DOI: 10.1126/science.1251141.Peer-Reviewed Original ResearchConceptsAssociated with reduced blood flowImproved olfactory discriminationAdult central nervous systemDecline of neurogenesisAged mouse brainAge-related declineCentral nervous systemNegative effects of agingNeural stem cellsOlfactory discriminationAge-related decline of neurogenesisCognitive functionAged miceIncreased neurogenesisNeural stem cell behaviorVascular remodelingSecreted factorsEffects of ageEnhanced neurogenesisYoung bloodStem cellsStem cell behaviorBlood flowNeurogenic nicheNervous system
2013
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
Loffredo F, Steinhauser M, Jay S, Gannon J, Pancoast J, Yalamanchi P, Sinha M, Dall’Osso C, Khong D, Shadrach J, Miller C, Singer B, Stewart A, Psychogios N, Gerszten R, Hartigan A, Kim M, Serwold T, Wagers A, Lee R. Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy. Cell 2013, 153: 828-839. PMID: 23663781, PMCID: PMC3677132, DOI: 10.1016/j.cell.2013.04.015.Peer-Reviewed Original ResearchConceptsCardiac hypertrophyYoung miceOld miceCirculating factorsTreatment of old miceAge-related hypertrophyReduced cardiomyocyte sizeGrowth differentiation factor 11Aptamer-based proteomicsDifferentiation factor 11Blood-borne factorsReverse age-related cardiac hypertrophyCardiomyocyte sizeHeart failureSurgical techniqueHypertrophyCardiac agingHeterochronic parabiosisTherapeutic opportunitiesTGF-bFactor 11Influence of circulation factorsBehavioral effectsMiceMolecular remodeling