2024
The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods
South A, Giammattei V, Bagley K, Bakhoum C, Beasley W, Bily M, Biswas S, Bridges A, Byfield R, Campbell J, Chanchlani R, Chen A, McGowan L, Downs S, Fergeson G, Greenberg J, Hill-Horowitz T, Jensen E, Kallash M, Kamel M, Kiessling S, Kline D, Laisure J, Liu G, Londeree J, Lucas C, Mannemuddhu S, Mao K, Misurac J, Murphy M, Nugent J, Onugha E, Pudupakkam A, Redmond K, Riar S, Sethna C, Siddiqui S, Thumann A, Uss S, Vincent C, Viviano I, Walsh M, White B, Woroniecki R, Wu M, Yamaguchi I, Yun E, Weaver D. The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods. American Journal Of Epidemiology 2024, kwae116. PMID: 38881045, DOI: 10.1093/aje/kwae116.Peer-Reviewed Original ResearchManual record reviewHypertensive disordersRecord reviewElectronic health record dataICD-10Health record dataInternational Classification of Diseases diagnostic codesReduce CVD burdenPrevalence of hypertensionIncreased prevalence of hypertensionCardiovascular mortality ratesCVD burdenBlood pressureInternational ClassificationDiagnostic codesClinical careRecord dataInclusion criteriaLife courseIncreased prevalencePediatric hypertensionLong-term consequencesMortality rateEpidemiologyBiomedical informatics
2023
Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox modelDoes This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentation
2022
Urine Uromodulin Is Not Associated With Blood Pressure in the Chronic Kidney Disease in Children Cohort
Bakhoum CY, Matheson MB, Greenberg JH, Furth SL, Ix JH, Garimella PS. Urine Uromodulin Is Not Associated With Blood Pressure in the Chronic Kidney Disease in Children Cohort. Hypertension 2022, 79: 2298-2304. PMID: 35920156, PMCID: PMC9458625, DOI: 10.1161/hypertensionaha.122.19566.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseClinic blood pressureSystolic blood pressureBlood pressureUromodulin levelsKidney diseaseChild CohortMean systolicSodium intakeClinic systolic blood pressureMean systolic blood pressureHealthy pediatric cohortDiastolic blood pressureGlomerular filtration rateHigh blood pressureMultivariable linear regression modelsLoop of HenleUrine uromodulinDietary sodiumMedian ageSalt intakePediatric cohortFiltration rateGlomerular diseaseMultivariable model
2021
Prevalence of subclinical retinal ischemia in patients with cardiovascular disease – a hypothesis driven study
Long CP, Chan AX, Bakhoum CY, Toomey CB, Madala S, Garg AK, Freeman WR, Goldbaum MH, DeMaria AN, Bakhoum MF. Prevalence of subclinical retinal ischemia in patients with cardiovascular disease – a hypothesis driven study. EClinicalMedicine 2021, 33: 100775. PMID: 33842865, PMCID: PMC8020165, DOI: 10.1016/j.eclinm.2021.100775.Peer-Reviewed Original ResearchAdverse cardiovascular eventsASCVD risk scoreCardiovascular diseaseCardiovascular eventsRetinal ischemiaHealthy controlsRisk scoreCardiovascular disease risk calculatorsUC San Diego HealthAtherosclerotic cardiovascular disease risk calculatorOptical coherence tomography scansHemoglobin A1c levelsSystolic blood pressureSan Diego HealthCause of mortalityIschemic infarctSmoking historyA1c levelsBlood pressureRisk calculatorNoninvasive testsOdds ratioTomography scanAdditional biomarkersRetinal pathologyProteinuria and nocturnal blood pressure dipping in hypertensive children and adolescents
Bakhoum CY, Vuong KT, Carter CE, Gabbai FB, Ix JH, Garimella PS. Proteinuria and nocturnal blood pressure dipping in hypertensive children and adolescents. Pediatric Research 2021, 90: 876-881. PMID: 33504962, PMCID: PMC8313642, DOI: 10.1038/s41390-020-01315-3.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringBody mass indexAssociation of proteinuriaBlood pressureRisk factorsUrine PCRNocturnal blood pressure dippingKidney function declineNocturnal blood pressureAdverse cardiovascular outcomesElevated blood pressureModifiable risk factorsDiastolic blood pressureGlomerular filtration rateBlood pressure dippingBlood pressure monitoringSpot urine proteinHypertensive childrenImpactOur studyCardiovascular outcomesCreatinine ratioFunction declineMass indexProspective studyUrine protein
2020
The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial
Bakhoum CY, Anderson CAM, Juraschek SP, Rebholz CM, Appel LJ, Miller ER, Parikh CR, Obeid W, Rifkin DE, Ix JH, Garimella PS. The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial. American Journal Of Hypertension 2020, 34: 154-156. PMID: 32856709, PMCID: PMC7951043, DOI: 10.1093/ajh/hpaa140.Peer-Reviewed Original ResearchConceptsSystolic blood pressureUrine uromodulinUromodulin levelsBlood pressureSodium dietSalt intakeDASH-Sodium trialHigh sodium dietHigh salt intakeHigh-salt dietSalt-induced hypertensionBlood pressure changesBody mass indexMultivariable linear regressionLoop of HenleHigher baseline levelsThick ascending limbFeeding periodGreater increaseSodium trialSalt dietDietary ApproachesMass indexRandomized trialsSBP change