2017
The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion
Christiano R, Kolev NG, Shi H, Ullu E, Walther TC, Tschudi C. The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion. Molecular Microbiology 2017, 106: 74-92. PMID: 28742275, PMCID: PMC5607103, DOI: 10.1111/mmi.13754.Peer-Reviewed Original ResearchConceptsInfectious metacyclic formsTsetse fly vectorMetacyclic formsVariant surface glycoprotein expression sitesQuiescent cellsGene expression profilesFly vectorsAvailability of nutrientsMammalian invasionsCell surface componentsCell divisionProcyclic trypanosomesMammalian hostsTrypanosoma bruceiMRNA sequencingExpression profilesExpression sitesMetabolic enzymesBloodstream formsInfectious metacyclicsProtein 6TranscriptomeTsetse fliesProteomeProtein levels
1988
Polygene transcripts are precursors to calmodulin mRNAs in trypanosomes.
Tschudi C, Ullu E. Polygene transcripts are precursors to calmodulin mRNAs in trypanosomes. The EMBO Journal 1988, 7: 455-463. PMID: 3366120, PMCID: PMC454342, DOI: 10.1002/j.1460-2075.1988.tb02833.x.Peer-Reviewed Original ResearchConceptsCalmodulin mRNACultured procyclic trypanosomesAbundant RNA speciesSteady-state RNAPulse-labeled RNAAuthentic precursorIntergenic regionRNA speciesProcyclic trypanosomesCalmodulin genePolyadenylation sitesAfrican trypanosomesHybridization probesTranscriptsStreptavidin-agaroseDiscrete endsSmall familyTrypanosomesMRNAGenesRNASpeciesCalmodulinTrypanosoma brucei gambienseBrucei gambiense