2011
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
Tsetsenis T, Younts T, Chiu C, Kaeser P, Castillo P, Südhof T. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 14300-14305. PMID: 21844341, PMCID: PMC3161598, DOI: 10.1073/pnas.1112237108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalExcitatory Postsynaptic PotentialsExtinction, PsychologicalFearGene DeletionHippocampusInhibitory Postsynaptic PotentialsLong-Term Synaptic DepressionMiceMice, KnockoutModels, NeurologicalRab3 GTP-Binding ProteinsReversal LearningSynapsesSynaptic TransmissionConceptsLong-term potentiationI-LTDLong-term depressionInhibitory synapsesRab3-interacting moleculeEndocannabinoid-dependent long-term depressionLong-term plasticityRab3 isoformsKO miceMorris water-mazeFear conditioning assaysPresynaptically expressed long-term potentiationNMDA receptor-dependent long-term potentiationInitial phase of learningHippocampal inhibitory synapsesPhases of learningReversal learningWater-mazeGTP-dependent mannerSynaptic vesicle proteinsAcute slicesCA1 regionPresynaptic formShort-term plasticityExcitatory synapses
2010
TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
Chávez A, Chiu C, Castillo P. TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus. Nature Neuroscience 2010, 13: 1511-1518. PMID: 21076423, PMCID: PMC3058928, DOI: 10.1038/nn.2684.Peer-Reviewed Original ResearchConceptsDentate gyrusLong-term depressionInternalization of AMPA receptorsActivation of TRPV-1Postsynaptic long-term depressionExcitatory synaptic transmissionEndocannabinoid receptorsAMPA receptorsTRPV-1TRPV1 activationGyrusSynaptic transmissionDentateClathrin-dependent internalizationReceptorsEndocannabinoidAnandamideDepressionTRPV1