2011
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
Tsetsenis T, Younts T, Chiu C, Kaeser P, Castillo P, Südhof T. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 14300-14305. PMID: 21844341, PMCID: PMC3161598, DOI: 10.1073/pnas.1112237108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalExcitatory Postsynaptic PotentialsExtinction, PsychologicalFearGene DeletionHippocampusInhibitory Postsynaptic PotentialsLong-Term Synaptic DepressionMiceMice, KnockoutModels, NeurologicalRab3 GTP-Binding ProteinsReversal LearningSynapsesSynaptic TransmissionConceptsLong-term potentiationI-LTDLong-term depressionInhibitory synapsesRab3-interacting moleculeEndocannabinoid-dependent long-term depressionLong-term plasticityRab3 isoformsKO miceMorris water-mazeFear conditioning assaysPresynaptically expressed long-term potentiationNMDA receptor-dependent long-term potentiationInitial phase of learningHippocampal inhibitory synapsesPhases of learningReversal learningWater-mazeGTP-dependent mannerSynaptic vesicle proteinsAcute slicesCA1 regionPresynaptic formShort-term plasticityExcitatory synapsesLong-term plasticity at inhibitory synapses
Castillo P, Chiu C, Carroll R. Long-term plasticity at inhibitory synapses. Current Opinion In Neurobiology 2011, 21: 328-338. PMID: 21334194, PMCID: PMC3092861, DOI: 10.1016/j.conb.2011.01.006.Peer-Reviewed Original ResearchConceptsSynaptic plasticityInhibitory synaptic plasticityModification of neural circuitsNeural circuitsNeural circuit refinementNeural circuit functionGABAergic plasticityRegulate excitabilityExcitatory/inhibitory balanceInhibitory plasticityCircuit refinementExcitatory synapsesLong-term plasticitySynaptic efficacyFunctional relevanceCircuit functionDiverse mechanismsLTP/LTDEfficacySynapses
2007
Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus
Chiu C, Castillo P. Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology 2007, 54: 68-78. PMID: 17706254, PMCID: PMC2225485, DOI: 10.1016/j.neuropharm.2007.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornArachidonic AcidsBenzoxazinesCalciumCalcium Channel BlockersCannabinoid Receptor ModulatorsCholinergic AgentsDentate GyrusElectric StimulationEndocannabinoidsExcitatory Postsynaptic PotentialsGlyceridesIn Vitro TechniquesMiceMice, Inbred C57BLMice, KnockoutMorpholinesNaphthalenesNeural PathwaysNeuronal PlasticityNeuronsPatch-Clamp TechniquesRatsRats, WistarReceptor, Cannabinoid, CB1ConceptsECB signalingDentate gyrusDiacyglycerol lipaseGroup I metabotropic glutamate receptorsDepress excitatory synaptic transmissionSuppression of excitationBreakdown of anandamideExcitatory synapsesMedial perforant pathAbundant eCBECB-LTDECB releaseCannabinoid receptorsExcitatory synaptic transmissionBrain structuresGlutamatergic inputsEntorhinal cortexSynaptic plasticityGlutamate receptorsPerforant pathDentate granule cellsDentateEndocannabinoidGyrusAnandamide