2022
Frame-Guided Assembly of Amphiphiles
Dong Y, Yang Y, Lin C, Liu D. Frame-Guided Assembly of Amphiphiles. Accounts Of Chemical Research 2022, 55: 1938-1948. PMID: 35786832, DOI: 10.1021/acs.accounts.2c00234.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsHydrophobic and Hydrophilic InteractionsLiposomesMembrane ProteinsNanostructuresProspective StudiesConceptsFrame-guided assemblyMolecular structureAssembly of amphiphilesArrangement of moleculesTraditional chemical industryMembrane protein incorporationProtein-lipid bilayerAmphiphilic assembliesAssembly morphologyAmphiphile assembliesFunctional nanomaterialsVersatile strategyAqueous environmentHydrophobic groupsHydrophobic moleculesFull surface areaHydrophobic interactionsAmphiphilesDrug deliveryMembrane proteinsFunctional complexAmphiphile concentrationAssembly strategyEPR effectNanomaterials
2021
FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria
Landajuela A, Braun M, Rodrigues CDA, Martínez-Calvo A, Doan T, Horenkamp F, Andronicos A, Shteyn V, Williams ND, Lin C, Wingreen NS, Rudner DZ, Karatekin E. FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria. PLOS Biology 2021, 19: e3001314. PMID: 34185788, PMCID: PMC8274934, DOI: 10.1371/journal.pbio.3001314.Peer-Reviewed Original ResearchConceptsMembrane fissionMembrane fission machineryMother cell membraneNegative-curvature lipidsMother cell cytoplasmUnique membrane topologyFission machineryMembrane scissionMembrane topologyLipid microdomainsMembrane necksFission proteinsLipid bindingMembrane curvatureFilamentous cellsBacillus subtilisFisBProtein BCell cytoplasmAcidic lipidsCell membraneCurvature sensingImmobile clustersIntrinsic abilityBacteria
2015
Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold
Raschle T, Lin C, Jungmann R, Shih WM, Wagner G. Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold. ACS Chemical Biology 2015, 10: 2448-2454. PMID: 26356202, PMCID: PMC4769731, DOI: 10.1021/acschembio.5b00627.Peer-Reviewed Original ResearchMeSH KeywordsDNAFluorescent DyesIon ChannelsLipid BilayersMembrane ProteinsMicroscopy, FluorescenceModels, BiologicalNanostructuresNuclear MatrixConceptsMembrane protein complexesMultiple membrane proteinsVoltage-gated anion channelsMembrane proteinsProtein complexesHeterotrimeric membrane protein complexIndividual membrane proteinsLipid bilayer nanodiscsSingle nanodiscBilayer nanodiscsProtein aggregationMembrane environmentAnion channelNanodiscsProteinLipid bilayersModel systemProof of principleOligonucleotide sequencesComplementary oligonucleotide sequencesComplexesTemporary attachmentDNASequenceBilayers