Featured Publications
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels
Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell G, Yang R, Aiken C, Engelman A, Lusk C, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nature Structural & Molecular Biology 2023, 30: 425-435. PMID: 36807645, PMCID: PMC10121901, DOI: 10.1038/s41594-023-00925-9.Peer-Reviewed Original ResearchConceptsNuclear pore complexHIV-1 nuclear entryNuclear entryNuclear importNPC central channelPore complexHost nucleusCapsid dockingVirus genomeAffinity gradientNup153Central channelMechanistic insightsMolecular interactionsCapsidNucleoporinsNup358Nup62GenomeNucleusVirusDockingVirus-1 infectionImportComplexes
2018
Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape
Bastings MMC, Anastassacos FM, Ponnuswamy N, Leifer FG, Cuneo G, Lin C, Ingber DE, Ryu JH, Shih WM. Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape. Nano Letters 2018, 18: 3557-3564. PMID: 29756442, DOI: 10.1021/acs.nanolett.8b00660.Peer-Reviewed Original ResearchConceptsDNA nanotechnologyStructural DNA nanotechnologyThree-dimensional nanostructuresCellular uptakeDNA origami shapesDesigner nanoparticlesNanoparticle uptakeDNA origamiCell delivery vehicleTherapeutic deliveryAttractive platformCell uptakeNanotechnologyNanoparticlesGreater compactnessDifferent cell linesUnparalleled abilityNanostructuresResolution featuresLarge particlesLimited controlParticle shapeOrigamiRatio particlesParticles