Featured Publications
Vesicle Tubulation with Self‐Assembling DNA Nanosprings
Grome MW, Zhang Z, Pincet F, Lin C. Vesicle Tubulation with Self‐Assembling DNA Nanosprings. Angewandte Chemie International Edition 2018, 57: 5330-5334. PMID: 29575478, PMCID: PMC5924453, DOI: 10.1002/anie.201800141.Peer-Reviewed Original ResearchConceptsMembrane-deforming proteinsDNA origami designMembrane tubulationMembrane tubulesMembrane curvatureMembrane surface coverageVesicle tubulationDNA structureLipid bilayersTubulationNanospringsTube morphologyIntricate interplayArtificial nanomachinesVesicle deformationSpherical vesiclesNanotechnologyMajor goalProteinDNAVesiclesNanomachinesBioengineeringDetergentsMorphologyIn vivo cloning of artificial DNA nanostructures
Lin C, Rinker S, Wang X, Liu Y, Seeman NC, Yan H. In vivo cloning of artificial DNA nanostructures. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 17626-17631. PMID: 18927233, PMCID: PMC2584761, DOI: 10.1073/pnas.0805416105.Peer-Reviewed Original ResearchConceptsArtificial DNA nanostructuresDNA nanostructuresDNA nanotechnologyGenetic information carriersStandard molecular biology techniquesNanostructuresVersatile methodFour-arm junctionsVivo cloningMolecular biology techniquesNumber of assaysComplex secondary structureBiology techniquesNanotechnologyHigh copy numberLiving cellsFerguson analysisHelper phageCorrect replicationPossible solutionsSecondary structureCopy numberPhagemidCarriersDNA
2023
Recent Advances in DNA Origami-Engineered Nanomaterials and Applications
Zhan P, Peil A, Jiang Q, Wang D, Mousavi S, Xiong Q, Shen Q, Shang Y, Ding B, Lin C, Ke Y, Liu N. Recent Advances in DNA Origami-Engineered Nanomaterials and Applications. Chemical Reviews 2023, 123: 3976-4050. PMID: 36990451, PMCID: PMC10103138, DOI: 10.1021/acs.chemrev.3c00028.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDNA origami techniquePaul RothemundDNA nanotechnologyOrigami techniqueExciting achievementsNanomaterialsMaterials scienceRecent progressRecent advancesNanotechnologyUseful applicationsApplicationsRothemundSignificant advancesUnexplored research avenuesOriginal proposalFieldPhysicsMathematicsEngineeringAdvancesUnique field
2021
DNA origami
Dey S, Fan C, Gothelf K, Li J, Lin C, Liu L, Liu N, Nijenhuis M, Saccà B, Simmel F, Yan H, Zhan P. DNA origami. Nature Reviews Methods Primers 2021, 1: 13. DOI: 10.1038/s43586-020-00009-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsDNA origami technologyOrigami technologyDNA origami techniqueNear-atomic precisionDNA nanotechnologyOrigami techniqueDNA origamiDrug deliveryOrigami structuresMolecular machinesOrigami designBiological materialsLiving cellsSynthesisVivo synthesisNanophotonicsNanotechnologyNanofabricationNanostructuresNanoelectronicsBioimagingScale of productionFabricationTechnologyFunctionalization
2018
Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape
Bastings MMC, Anastassacos FM, Ponnuswamy N, Leifer FG, Cuneo G, Lin C, Ingber DE, Ryu JH, Shih WM. Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape. Nano Letters 2018, 18: 3557-3564. PMID: 29756442, DOI: 10.1021/acs.nanolett.8b00660.Peer-Reviewed Original ResearchConceptsDNA nanotechnologyStructural DNA nanotechnologyThree-dimensional nanostructuresCellular uptakeDNA origami shapesDesigner nanoparticlesNanoparticle uptakeDNA origamiCell delivery vehicleTherapeutic deliveryAttractive platformCell uptakeNanotechnologyNanoparticlesGreater compactnessDifferent cell linesUnparalleled abilityNanostructuresResolution featuresLarge particlesLimited controlParticle shapeOrigamiRatio particlesParticles
2011
Synthesis and Characterization of Self-Assembled DNA Nanostructures
Lin C, Ke Y, Chhabra R, Sharma J, Liu Y, Yan H. Synthesis and Characterization of Self-Assembled DNA Nanostructures. Methods In Molecular Biology 2011, 749: 1-11. PMID: 21674361, DOI: 10.1007/978-1-61779-142-0_1.ChaptersConceptsDNA nanostructuresDNA nanotechnologySelf-assembled DNA nanostructuresSuch nanoscale objectsStructural DNA nanotechnologyCharacterization of SelfDNA-based nanodevicesExcellent yieldsNanoscale objectsNanostructuresArtificial nanostructuresMolecular speciesBuilding blocksNanotechnologyFast evolvementMain building blocksNanoarchitecturesLarge varietySynthesisMaterialsNanodevicesPreparationCharacterizationBuilding materialsYield
2009
Designer DNA Nanoarchitectures
Lin C, Liu Y, Yan H. Designer DNA Nanoarchitectures. Biochemistry 2009, 48: 1663-1674. PMID: 19199428, PMCID: PMC2765550, DOI: 10.1021/bi802324w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStructural DNA nanotechnologyDNA nanotechnologyDNA nanoarchitecturesSelf-assembled architecturesWatson-Crick base pairing rulesProtein-protein interactionsBase pairing rulesDNA nanostructuresMulticomponent nanomachinesPrinciples of DNAArtificial nanostructuresNanometer precisionHelical DNA structureUnicellular diatomsFunctional groupsDNA structureNanotechnologyNanostructuresMolecular speciesNanoarchitecturesSuch eleganceExciting progressHigh yieldsBiological systemsDNA
2008
Mirror Image DNA Nanostructures for Chiral Supramolecular Assemblies
Lin C, Ke Y, Li Z, Wang JH, Liu Y, Yan H. Mirror Image DNA Nanostructures for Chiral Supramolecular Assemblies. Nano Letters 2008, 9: 433-436. PMID: 19063615, PMCID: PMC2669104, DOI: 10.1021/nl803328v.Peer-Reviewed Original ResearchConceptsChiral supramolecular assembliesStructural DNA nanotechnologyNatural d-DNACircular dichroism spectraSupramolecular assembliesDNA supramoleculesAtomic force microscopeDNA nanostructuresDNA nanotechnologyL-DNADichroism spectraVivo medical applicationsNuclease resistanceForce microscopePolyacrylamide gel electrophoresisOpposite chiralityNanostructuresD-DNAPeriodic nanostructuresMedical applicationsSupramoleculesGel electrophoresisSubstantial complementChiralityNanotechnology