β-Cell Secretory Capacity Predicts Metabolic Outcomes over 6 Years following Human Islet Transplantation.
Flatt A, Matus A, Gallop R, Markmann E, Dalton-Bakes C, Peleckis A, Liu C, Naji A, Rickels M. β-Cell Secretory Capacity Predicts Metabolic Outcomes over 6 Years following Human Islet Transplantation. Diabetes 2024 PMID: 39630971, DOI: 10.2337/db24-0729.Peer-Reviewed Original ResearchPurified human pancreatic isletsB-cell massB-cell secretory capacityHuman pancreatic isletsSecretory capacityProinsulin secretory ratiosInsulin independenceBeta 2Pancreatic isletsMeasures of graft functionHormone metabolismSecretory ratioIntra-portal infusionOne-year post-transplantGlucose-potentiated arginineType 1 diabetesGraft functionPost-transplantB cellsIsletsMetabolic outcomesFasting glucagonHuman islet transplantationSustained insulin independence