2024
1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D)
FLATT A, MATUS A, GALLOP R, MARKMANN E, DALTON-BAKES C, PELECKIS A, LIU C, NAJI A, RICKELS M. 1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D). Diabetes 2024, 73 DOI: 10.2337/db24-1507-p.Peer-Reviewed Original ResearchMixed-meal tolerance testB-cell secretory capacityGlucose-potentiated arginineC-peptideBeta 2Secretory capacityBETA-2 scoreRepeated-measures correlation analysisYears post-transplantB cell functionIslet transplantationModerate effect sizeAllogeneic islet transplantationC-peptide/glucose ratioType 1 diabetesIslet graft functionGraft functionPost-transplantGraft monitoringTolerance testC-peptide/glucoseTransplantationLongitudinal cohortEffect sizeSS cells
2022
Alloantigen-specific Chimeric Antigen Receptor Regulatory T cell therapy in non-human primate islet transplantation
Ellis G, Coker K, Winn D, Deng M, Shukla D, Bhoj V, Milone M, Wang W, Liu C, Naji A, Duran-Struuck R, Riley J. Alloantigen-specific Chimeric Antigen Receptor Regulatory T cell therapy in non-human primate islet transplantation. The Journal Of Immunology 2022, 208: 175.21-175.21. DOI: 10.4049/jimmunol.208.supp.175.21.Peer-Reviewed Original ResearchCAR-TregsLarge animal modelPeripheral bloodIslet transplantationT cellsAnimal modelsRegulatory T cell therapyArtificial antigen presenting cellsCAR-Treg therapyEffector T cellsT-cell therapyAntigen presenting cellsOptimization of therapyType 1 diabetesCAR T cellsExpanded TregsTreg therapyAdoptive transferGraft rejectionAdoptive therapyDiabetic recipientsImmunosuppressive agentsNegative recipientsTreatment of cancerBlood glucose