Checkpoint kinase 2 controls insulin secretion and glucose homeostasis
Chong A, Vandana J, Jeng G, Li G, Meng Z, Duan X, Zhang T, Qiu Y, Duran-Struuck R, Coker K, Wang W, Li Y, Min Z, Zuo X, de Silva N, Chen Z, Naji A, Hao M, Liu C, Chen S. Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Nature Chemical Biology 2023, 20: 566-576. PMID: 37945898, PMCID: PMC11062908, DOI: 10.1038/s41589-023-01466-4.Peer-Reviewed Original ResearchGlucose-stimulated insulin secretionInsulin secretionHuman β-cellsCynomolgus macaquesΒ-cellsImproved glucose clearanceType 2 diabetic human isletsDiabetic mouse modelDiabetic human isletsHuman β-cell lineDiscovery of insulinT2D conditionsΒ-cell lineGlucose toleranceGlucose clearanceMouse modelGlucose homeostasisMice showHuman isletsSecretionVivo studiesUntargeted metabolic profilingCell linesCheckpoint kinase 2Islets