The biliary atresia susceptibility gene, EFEMP1, regulates extrahepatic bile duct elastic fiber formation and mechanics
Gupta K, Llewellyn J, Roberts E, Liu C, Naji A, Assoian R, Wells R. The biliary atresia susceptibility gene, EFEMP1, regulates extrahepatic bile duct elastic fiber formation and mechanics. JHEP Reports 2024, 101215. DOI: 10.1016/j.jhepr.2024.101215.Peer-Reviewed Original ResearchExtrahepatic bile ductNeonatal extrahepatic bile ductsBiliary atresiaSusceptibility genesBile ductFibulin-3Genome wide association studiesExtracellular matrix protein 1Pressure myographyGene EFEMP1Elastic fibersExtracellular matrix proteinsAssociation studiesHuman extrahepatic bile ductsExtracellular matrix componentsElastic fiber organizationMatrix protein 1Decreased elastic fibersBile duct structuresMatrix proteinsFormation of elastic fibersFunctional relevanceGenesFiber formationNormal ducts