2023
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome
Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh A, Nelson C, Bryer J, Ashchyan H, Steele K, Forrestel A, Seykora J, Micheletti R, James W, Rosenbach M, Leung T. Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome. Journal Of Clinical Investigation 2023, 133: e162137. PMID: 36355435, PMCID: PMC9797331, DOI: 10.1172/jci162137.Peer-Reviewed Original ResearchConceptsSteroid-sparing agentSweet's syndromeInflammatory diseasesCorticosteroid-related side effectsElevated IL-1Febrile neutrophilic dermatosisDramatic therapeutic responseReceptor 1 antagonistNeutrophil respiratory burstMultiorgan inflammatory diseasePersonalized medicine approachPI3K/AktSuccessful clinical interventionNeutrophilic dermatosisFrontline therapyRefractory casesNeutrophilic infiltrateBlood countIL-1βNeutrophil functionNeutrophil migrationTherapeutic responseLiver enzymesClinical challengeIL-1
2020
Geographic disparities in access to scalp cooling for the prevention of chemotherapy-induced alopecia in the United States
Singer S, Tkachenko E, Sharma P, Nelson C, Mostaghimi A, LeBoeuf NR. Geographic disparities in access to scalp cooling for the prevention of chemotherapy-induced alopecia in the United States. Journal Of The American Academy Of Dermatology 2020, 85: 1248-1252. PMID: 32610170, DOI: 10.1016/j.jaad.2020.06.073.Peer-Reviewed Original ResearchPatient Perspectives on the Use of Artificial Intelligence for Skin Cancer Screening
Nelson CA, Pérez-Chada LM, Creadore A, Li SJ, Lo K, Manjaly P, Pournamdari AB, Tkachenko E, Barbieri JS, Ko JM, Menon AV, Hartman RI, Mostaghimi A. Patient Perspectives on the Use of Artificial Intelligence for Skin Cancer Screening. JAMA Dermatology 2020, 156: 501-512. PMID: 32159733, PMCID: PMC7066525, DOI: 10.1001/jamadermatol.2019.5014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArtificial IntelligenceBiopsyEarly Detection of CancerFemaleGrounded TheoryHealth Services AccessibilityHumansInterviews as TopicMaleMass ScreeningMelanomaMiddle AgedObserver VariationPatient Acceptance of Health CarePhysician-Patient RelationsQualitative ResearchReproducibility of ResultsSkin NeoplasmsConceptsSkin cancer screeningCancer screeningSkin cancerPatient's perspectiveAccurate diagnosisDana-Farber Cancer InstituteGeneral dermatology clinicNonmelanoma skin cancerHistory of melanomaHealth care accessPhysician-patient relationshipMelanoma clinicDermatology clinicWomen's HospitalPatient anxietySkin lesionsMAIN OUTCOMECare accessCancer InstitutePatientsQualitative studyCancerHealth careClinicHospitalA Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria
Nelson CA, Zhong CS, Hashemi DA, Ashchyan HJ, Brown-Joel Z, Noe MH, Imadojemu S, Micheletti RG, Vleugels RA, Wanat KA, Rosenbach M, Mostaghimi A. A Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria. JAMA Dermatology 2020, 156: 270-279. PMID: 31940000, PMCID: PMC6990734, DOI: 10.1001/jamadermatol.2019.4221.Peer-Reviewed Original ResearchConceptsMulticenter cross-sectional studyNecrobiotic xanthogranulomaCross-sectional studyPlasma cell dyscrasiaDiagnostic criteriaMulticenter cohortMalignant conditionsConsensus exerciseSystematic reviewPeriorbital distributionLymphoproliferative disordersCutaneous lesionsMultiple myelomaMinor criteriaBetter treatment response rateDiagnosis of NXGTertiary academic referral centerNon-Langerhans cell histiocytosisAcademic referral centerTreatment response ratesPennsylvania Health SystemMassachusetts General HospitalBoard-certified dermatologistsIntralesional triamcinoloneIntravenous immunoglobulin
2019
Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes
Hashemi DA, Brown-Joel ZO, Tkachenko E, Nelson CA, Noe MH, Imadojemu S, Vleugels RA, Mostaghimi A, Wanat KA, Rosenbach M. Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes. JAMA Dermatology 2019, 155: 455-459. PMID: 30785603, PMCID: PMC6523472, DOI: 10.1001/jamadermatol.2018.5635.Peer-Reviewed Original ResearchConceptsNecrobiosis lipoidicaClinical featuresThyroid diseaseDiagnosis of NLRare granulomatous conditionComorbidities of patientsMulticenter retrospective reviewElevated blood glucosePennsylvania Health SystemMassachusetts General HospitalNL lesionsNotable comorbiditiesMedical comorbiditiesMedian hemoglobinPatient demographicsMedian ageRetrospective reviewEpidemiologic characteristicsPathophysiologic characteristicsBiopsy statusGranulomatous conditionsCase reportFemale sexBlood glucoseRisk factors
2018
The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum
Ashchyan HJ, Butler DC, Nelson CA, Noe MH, Tsiaras WG, Lockwood SJ, James WD, Micheletti RG, Rosenbach M, Mostaghimi A. The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum. JAMA Dermatology 2018, 154: 409-413. PMID: 29450453, PMCID: PMC5876860, DOI: 10.1001/jamadermatol.2017.5978.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseHematologic malignant neoplasmsMedical comorbiditiesMalignant neoplasmsAssociation of agePyoderma gangrenosumClinical presentationBowel diseaseHematologic disordersMulticenter retrospective cohort studyTertiary academic referral centerInflammatory neutrophilic dermatosisPatients 65 yearsRetrospective cohort studyAcademic referral centerAge-specific evaluationPennsylvania Health SystemMassachusetts General HospitalLarge population studiesDifferent age groupsNeutrophilic dermatosisCohort studyInflammatory arthritisPatient demographicsReferral center
2017
Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center
Nelson CA, Noe MH, McMahon CM, Gowda A, Wu B, Ashchyan HJ, Perl AE, James WD, Micheletti RG, Rosenbach M. Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center. Journal Of The American Academy Of Dermatology 2017, 78: 303-309.e4. PMID: 29107342, DOI: 10.1016/j.jaad.2017.09.013.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdrenal Cortex HormonesAdultAgedAnemiaArthralgiaColchicineDapsoneFemaleFilgrastimFms-Like Tyrosine Kinase 3Folic Acid AntagonistsHematologic AgentsHumansInflammationLeukemia, Myeloid, AcuteLeukopeniaMaleMiddle AgedMutationNeoplasmsNuclear ProteinsNucleophosminPotassium IodideRetrospective StudiesSweet SyndromeTertiary Care CentersThrombocytopeniaTubulin ModulatorsConceptsTertiary academic referral centerAbsence of arthralgiaDrug-induced formsSweet's syndromeAcademic referral centerReferral centerSingle tertiary academic referral centerSetting of malignancyAcute myeloid leukemiaConcurrent malignancyNeutrophilic dermatosisClinicopathologic characteristicsCommon medicationsCommon malignancyRetrospective studyMyeloid leukemiaRetrospective analysisRare disorderPatientsMalignancySyndromePotential associationArthralgiaLeukopeniaThrombocytopenia
2015
Impact of store-and-forward (SAF) teledermatology on outpatient dermatologic care: A prospective study in an underserved urban primary care setting
Nelson CA, Takeshita J, Wanat KA, Bream KD, Holmes JH, Koenig HC, Roth RR, Vuppalapati A, James WD, Kovarik CL. Impact of store-and-forward (SAF) teledermatology on outpatient dermatologic care: A prospective study in an underserved urban primary care setting. Journal Of The American Academy Of Dermatology 2015, 74: 484-490.e1. PMID: 26679528, DOI: 10.1016/j.jaad.2015.09.058.Peer-Reviewed Original Research
2014
The Reliability of Teledermatology to Triage Inpatient Dermatology Consultations
Barbieri JS, Nelson CA, James WD, Margolis DJ, Littman-Quinn R, Kovarik CL, Rosenbach M. The Reliability of Teledermatology to Triage Inpatient Dermatology Consultations. JAMA Dermatology 2014, 150: 419-424. PMID: 24522374, DOI: 10.1001/jamadermatol.2013.9517.Peer-Reviewed Original Research