2023
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome
Bhattacharya S, Basu S, Sheng E, Murphy C, Wei J, Kersh A, Nelson C, Bryer J, Ashchyan H, Steele K, Forrestel A, Seykora J, Micheletti R, James W, Rosenbach M, Leung T. Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome. Journal Of Clinical Investigation 2023, 133: e162137. PMID: 36355435, PMCID: PMC9797331, DOI: 10.1172/jci162137.Peer-Reviewed Original ResearchConceptsSteroid-sparing agentSweet's syndromeInflammatory diseasesCorticosteroid-related side effectsElevated IL-1Febrile neutrophilic dermatosisDramatic therapeutic responseReceptor 1 antagonistNeutrophil respiratory burstMultiorgan inflammatory diseasePersonalized medicine approachPI3K/AktSuccessful clinical interventionNeutrophilic dermatosisFrontline therapyRefractory casesNeutrophilic infiltrateBlood countIL-1βNeutrophil functionNeutrophil migrationTherapeutic responseLiver enzymesClinical challengeIL-1
2018
Neutrophilic dermatoses Pathogenesis, Sweet syndrome, neutrophilic eccrine hidradenitis, and Behçet disease
Nelson CA, Stephen S, Ashchyan HJ, James WD, Micheletti RG, Rosenbach M. Neutrophilic dermatoses Pathogenesis, Sweet syndrome, neutrophilic eccrine hidradenitis, and Behçet disease. Journal Of The American Academy Of Dermatology 2018, 79: 987-1006. PMID: 29653210, DOI: 10.1016/j.jaad.2017.11.064.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAntineoplastic AgentsAutoimmune DiseasesBehcet SyndromeChemotaxis, LeukocyteCytokinesDermisDiagnosis, DifferentialDrug EruptionsEpidermisEthnicityGenetic Predisposition to DiseaseHidradenitisHumansImmunity, InnateImmunosuppressive AgentsInflammationNeoplasmsNeutrophilsSweet SyndromeVasculitisConceptsNeutrophilic eccrine hidradenitisNeutrophilic dermatosisSweet's syndromeBehçet's diseaseInflammatory skin disorderSignificant patient morbidityUnique clinical featuresMedical education seriesSystemic corticosteroidsBiologic agentsClinical featuresNeutrophilic infiltrateCutaneous lesionsHistopathologic featuresPatient morbidityTherapeutic modalitiesNeoplastic processSkin disordersDermatosesHeterogeneous groupDiseaseDiagnosisHidradenitisDisordersSyndromeNeutrophilic dermatoses Pyoderma gangrenosum and other bowel- and arthritis-associated neutrophilic dermatoses
Ashchyan HJ, Nelson CA, Stephen S, James WD, Micheletti RG, Rosenbach M. Neutrophilic dermatoses Pyoderma gangrenosum and other bowel- and arthritis-associated neutrophilic dermatoses. Journal Of The American Academy Of Dermatology 2018, 79: 1009-1022. PMID: 29653213, DOI: 10.1016/j.jaad.2017.11.063.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory AgentsArthritisArthritis, RheumatoidDiagnosis, DifferentialDigestive System Surgical ProceduresDisease ManagementHumansImmunosuppressive AgentsInflammationInflammatory Bowel DiseasesNeutrophilsPostoperative ComplicationsPyoderma GangrenosumReoperationSkin UlcerStill's Disease, Adult-OnsetWound HealingConceptsNeutrophilic dermatosisBowel-associated dermatosis-arthritis syndromeDermatosis-arthritis syndromeRheumatoid neutrophilic dermatitisInflammatory skin disorderSignificant patient morbidityUnique clinical featuresMedical education seriesNeutrophilic dermatitisSystemic corticosteroidsPyoderma gangrenosumClinical characteristicsBiologic agentsClinical featuresNeutrophilic infiltrateCutaneous lesionsHistopathologic featuresPatient morbidityTherapeutic modalitiesNeoplastic processSkin disordersDermatosesHeterogeneous groupDiagnosisGangrenosumThe Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum
Ashchyan HJ, Butler DC, Nelson CA, Noe MH, Tsiaras WG, Lockwood SJ, James WD, Micheletti RG, Rosenbach M, Mostaghimi A. The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum. JAMA Dermatology 2018, 154: 409-413. PMID: 29450453, PMCID: PMC5876860, DOI: 10.1001/jamadermatol.2017.5978.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseHematologic malignant neoplasmsMedical comorbiditiesMalignant neoplasmsAssociation of agePyoderma gangrenosumClinical presentationBowel diseaseHematologic disordersMulticenter retrospective cohort studyTertiary academic referral centerInflammatory neutrophilic dermatosisPatients 65 yearsRetrospective cohort studyAcademic referral centerAge-specific evaluationPennsylvania Health SystemMassachusetts General HospitalLarge population studiesDifferent age groupsNeutrophilic dermatosisCohort studyInflammatory arthritisPatient demographicsReferral center
2017
Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center
Nelson CA, Noe MH, McMahon CM, Gowda A, Wu B, Ashchyan HJ, Perl AE, James WD, Micheletti RG, Rosenbach M. Sweet syndrome in patients with and without malignancy: A retrospective analysis of 83 patients from a tertiary academic referral center. Journal Of The American Academy Of Dermatology 2017, 78: 303-309.e4. PMID: 29107342, DOI: 10.1016/j.jaad.2017.09.013.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdrenal Cortex HormonesAdultAgedAnemiaArthralgiaColchicineDapsoneFemaleFilgrastimFms-Like Tyrosine Kinase 3Folic Acid AntagonistsHematologic AgentsHumansInflammationLeukemia, Myeloid, AcuteLeukopeniaMaleMiddle AgedMutationNeoplasmsNuclear ProteinsNucleophosminPotassium IodideRetrospective StudiesSweet SyndromeTertiary Care CentersThrombocytopeniaTubulin ModulatorsConceptsTertiary academic referral centerAbsence of arthralgiaDrug-induced formsSweet's syndromeAcademic referral centerReferral centerSingle tertiary academic referral centerSetting of malignancyAcute myeloid leukemiaConcurrent malignancyNeutrophilic dermatosisClinicopathologic characteristicsCommon medicationsCommon malignancyRetrospective studyMyeloid leukemiaRetrospective analysisRare disorderPatientsMalignancySyndromePotential associationArthralgiaLeukopeniaThrombocytopenia