Featured Publications
Risk profiles, access to care, and outcomes in Hispanics hospitalized for lower extremity peripheral artery disease
Luna P, Harris K, Castro-Dominguez Y, Algara M, Severiche-Mena C, Smolderen KG, Mena-Hurtado C. Risk profiles, access to care, and outcomes in Hispanics hospitalized for lower extremity peripheral artery disease. Journal Of Vascular Surgery 2022, 77: 216-224.e15. PMID: 36037965, DOI: 10.1016/j.jvs.2022.08.021.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseLower extremity peripheral artery diseaseNon-Hispanic whitesEmergency departmentPAD careArtery diseaseRisk factorsSevere peripheral artery diseaseChronic limb-threatening ischemiaRisk profileNational Inpatient Sample dataCardiovascular risk factorsLimb-threatening ischemiaPatients' sociodemographic characteristicsWorse clinical outcomesMultivariable logistic regressionAssociation of ethnicityLength of stayHealth care consumptionHealth care coveragePAD hospitalizationsPrior amputationEndovascular revascularizationED admissionRenal failurePROGNOSTIC VALIDITY OF FRAILTY ASSESSMENT TOOLS IN PREDICTION OF MORTALITY AND MAJOR AMPUTATION IN PATIENTS UNDERGOING REVASCULARIZATION FOR LOWER EXTREMITY ARTERIAL DISEASE
Nikooie R, Smolderen K, Al-Damluji M, Meng C, Dai F, Nanna M, Sumpio B, Henke P, Mena-Hurtado C. PROGNOSTIC VALIDITY OF FRAILTY ASSESSMENT TOOLS IN PREDICTION OF MORTALITY AND MAJOR AMPUTATION IN PATIENTS UNDERGOING REVASCULARIZATION FOR LOWER EXTREMITY ARTERIAL DISEASE. Journal Of The American College Of Cardiology 2022, 79: 1779. DOI: 10.1016/s0735-1097(22)02770-x.Peer-Reviewed Original ResearchThe Nevada peripheral artery disease screening effort in a Medicare Advantage population and subsequent mortality and major adverse cardiovascular event risk
Smolderen K, Heath K, Scherr T, Bauzon S, Howell A, Mena-Hurtado C. The Nevada peripheral artery disease screening effort in a Medicare Advantage population and subsequent mortality and major adverse cardiovascular event risk. European Journal Of Vascular And Endovascular Surgery 2022, 63: e98. DOI: 10.1016/j.ejvs.2022.06.013.Peer-Reviewed Original ResearchGuideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions
Smolderen K, Romain G, Provance J, Scierka L, Mao J, Goodney P, Henke P, Sedrakyan A, Mena-Hurtado C. Guideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions. JACC Cardiovascular Interventions 2023, 16: 332-343. PMID: 36792257, PMCID: PMC10359106, DOI: 10.1016/j.jcin.2022.09.022.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyPeripheral vascular interventionsMedical therapyVascular interventionsEnzyme inhibitors/angiotensin receptor blockersVascular Quality Initiative registryAngiotensin receptor blockersLong-term mortalityRisk of amputationRisk of mortalityNational quality registryQuality improvement effortsAmputation outcomesAmputation riskMajor amputationAntiplatelet therapyCause mortalityReceptor blockersMean ageVascular careQuality registryObservational studyMortality riskHigh riskAmputation dataLongitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress ScaleInter-Rater Reliability for the Amputation Endpoint in the National Vascular Quality Initiative
Smolderen K, Romain G, Scierka L, Cleman J, Rahman M, Siddiqui W, Lau F, Mao J, Akhlaghi N, Higaki A, Fowler X, Carroll M, Telma K, Alvermann T, Baribeau V, Goodney P, Mena-Hurtado C. Inter-Rater Reliability for the Amputation Endpoint in the National Vascular Quality Initiative. JACC Cardiovascular Interventions 2024, 17: 622-631. PMID: 38479964, DOI: 10.1016/j.jcin.2024.01.003.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record reviewAmputation dataPeripheral arterial diseaseInterrater reliabilityVQI registryAcademic health systemTrained data collectorsNational quality registryInter-rater reliabilityEvaluate interrater reliabilityNational reporting systemHealth recordsQuality registryHealth systemCurrent Procedural Terminology codesInter-raterVascular Quality Initiative registryVascular Quality InitiativeProcedural Terminology codesNational Vascular Quality InitiativeRegistryQuality InitiativeAmputationSpearman's rRenal Denervation for the Treatment of Hypertension: A Scientific Statement From the American Heart Association
Cluett J, Blazek O, Brown A, East C, Ferdinand K, Fisher N, Ford C, Griffin K, Mena-Hurtado C, Sarathy H, Vongpatanasin W, Townsend R, Disease O. Renal Denervation for the Treatment of Hypertension: A Scientific Statement From the American Heart Association. Hypertension 2024, 81: e135-e148. PMID: 39101202, DOI: 10.1161/hyp.0000000000000240.Peer-Reviewed Original ResearchRenal denervationBlood pressureEfficacy of renal denervationUS Food and Drug AdministrationRandomized clinical studyRenal sympathetic nervesNovel treatment strategiesBlood pressure control ratesLonger-term efficacyIndividual patient responseLowering blood pressureFood and Drug AdministrationSpectrum of hypertensionTreatment of hypertensionControl blood pressureUncontrolled blood pressureMultiple ongoing studiesCatheter-based proceduresAmerican Heart AssociationHigh blood pressureTherapeutic optionsSafety profileCardiovascular morbidityControl rateHypertension specialistsUnderstanding the Pain Experience and Treatment Considerations Along the Spectrum of Peripheral Artery Disease: A Scientific Statement From the American Heart Association.
Smolderen KG, Ujueta F, Buckley Behan D, Vlaeyen JWS, Jackson EA, Peters M, Whipple M, Phillips K, Chung J, Mena-Hurtado C, American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and Outcomes Research. Understanding the Pain Experience and Treatment Considerations Along the Spectrum of Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circ Cardiovasc Qual Outcomes 2025, 18: e000135. PMID: 39925269, DOI: 10.1161/HCQ.0000000000000135.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAssociation Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Smolderen K, Samaan Z, Decker C, Collins T, Lazar R, Itoga N, Mena-Hurtado C, Research O. Association Between Mental Health Burden, Clinical Presentation, and Outcomes in Individuals With Symptomatic Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 1511-1528. PMID: 37781785, DOI: 10.1161/cir.0000000000001178.Peer-Reviewed Original ResearchConceptsPsychological interventionsPeripheral artery diseaseMental healthStress reduction interventionsSymptomatic peripheral artery diseaseComorbid mental health conditionsMental health concernsRole of painMental health conditionsMental health burdenPAD careCognitive declineBehavioral health needsArtery diseaseCognitive dysfunctionPsychotropic interventionScientific statementPAD treatmentBehavior changeUse of opioidsAmerican Heart AssociationUse of benzodiazepinesChronic disease managementHealth behaviorsFragmentation of care
2025
Carotid artery stenting with open versus closed stent cell configurations in the CREST-2 Registry
Lal B, Roubin G, Meschia J, Jones M, Heck D, Sternbergh W, Aronow H, Mena-Hurtado C, Howard G, Mayorga-Carlin M, Sorkin J, Brott T. Carotid artery stenting with open versus closed stent cell configurations in the CREST-2 Registry. Journal Of Vascular Surgery 2025 PMID: 40024381, DOI: 10.1016/j.jvs.2025.02.025.Peer-Reviewed Original ResearchCarotid artery stentingOpen-cell stentClosed-cell stentsFood and Drug Administration-approved deviceArtery stentingEmbolic protectionComparison of clinical outcomesStandardized procedure protocolsSymptomatic patientsPeri-proceduralAntiplatelet therapyPatient selectionClinical outcomesInstitutional experiencePatient characteristicsProcedural detailsCREST-2Lesion characteristicsLesion selectionHigh riskStentVascular anatomyPatient preferencesPatientsProcedure protocolEffect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025 PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseHospital readmissionRelative riskDiabetes mellitusRandom-effects meta-analysisIncreased riskMeta-analysisAssociation of DMExtremity revascularizationMortality riskWound infectionRisk estimatesAssociated with diabetes mellitusClinical outcomesSystematic reviewArtery diseaseSystematic searchObservational studyWound infection riskReadmissionEffects of diabetesAmputationRiskHospitalAssociation between guideline-directed medical therapy and reintervention risk following peripheral vascular interventions in patients with peripheral artery disease.
Callegari S, Romain G, Capuano I, Cleman J, Scierka L, Smolderen K, Mena-Hurtado C. Association between guideline-directed medical therapy and reintervention risk following peripheral vascular interventions in patients with peripheral artery disease. Vascular Medicine 2025, 1358863x251320347. PMID: 39992181, DOI: 10.1177/1358863x251320347.Peer-Reviewed Original ResearchGuideline-directed medical therapyGuideline-directed medical therapy ratesPeripheral vascular interventionsPeripheral arterial diseaseReintervention outcomesReintervention riskMedical therapyArtery diseaseVascular interventionsAngiotensin receptor blockersCompeting risk analysisScore-matched cohortReceipt of statinsPost-PVIAngiotensin-converting enzymeReceptor blockersReinterventionMedicare outcomesMedication adherencePatientsRegistry dataTherapyOutcomesReceiptRiskHealth Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study
Mosarla R, Chowdhury M, Smolderen K, Mena-Hurtado C, Spertus J, Yeh R, Secemsky E. Health Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study. The American Journal Of Cardiology 2025, 243: 22-31. PMID: 39894333, DOI: 10.1016/j.amjcard.2025.01.017.Peer-Reviewed Original ResearchPredictor of health statusHealth statusEQ-VASAssociated with health statusHealth status measuresTarget vessel/lesion revascularizationTotal scoreBaseline health statusAll-cause deathImprove health statusPeripheral endovascular interventionsHealth status improvementChronic limb-threatening ischemiaRepeated measures modelPeripheral arterial disease severitySymptomatic peripheral arterial diseaseStatus measuresPeripheral arterial diseaseLimb-threatening ischemiaLong-term improvementPeripheral vascular interventionsStatus improvementHealthMultivariate regressionClaudicationOutcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial
Malas M, Hamouda M, Farber A, Menard M, Conte M, Rosenfield K, Strong M, Doros G, Powell R, Mena-Hurtado C, Gasper W, Schermerhorn M, Allievi S, Smolderen K, Dake M, Rymer J, Tuttle K. Outcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial. Journal Of Vascular Surgery 2025, 81: 945-956.e3. PMID: 39846933, DOI: 10.1016/j.jvs.2024.12.128.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmputation, SurgicalChronic Limb-Threatening IschemiaEndovascular ProceduresFemaleGlomerular Filtration RateHumansIschemiaKidneyLimb SalvageMaleMiddle AgedPeripheral Arterial DiseaseProspective StudiesRenal DialysisRenal Insufficiency, ChronicRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsChronic limb-threatening ischemiaChronic kidney diseaseDialysis-dependent patientsBEST-CLIChronic kidney disease stagePrimary trial outcomeRisk of amputationAssociated with lower mortalityEndovascular therapyAll-cause mortalityHigh risk of poor outcomesRisk of poor outcomesEndovascular revascularizationKidney diseaseBEST-CLI trialOutcomes of lower extremity revascularizationAssociated with better survivalMultivariate Cox regression analysisBest Surgical TherapyIncreased reintervention rateStage 4 CKD patientsRisk of reinterventionGroup C patientsAdverse limb eventsChronic kidney disease severityDefining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting
Kluger J, Romain G, Mena‐Hurtado C, Grubman S, Pajarillo C, Cleman J, Scierka L, Smolderen K. Defining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting. Catheterization And Cardiovascular Interventions 2025, 105: 927-937. PMID: 39789704, DOI: 10.1002/ccd.31410.Peer-Reviewed Original ResearchConceptsMinimal clinically important differenceHealth status changesHealth statusSF-36Visual analog scaleEQ-5DDistribution-based MCIDPhysical component scoreCarotid artery stentingDisease-specific instrumentHealth status improvementTransfemoral carotid artery stentingSymptom statusClinically important differenceTF-CASStatus changesGeneric instrumentsArtery stentingRegistry dataComponent scoresImportant differencePatients no changeStatus improvementAsymptomatic carotid stenosisHealthInteraction of anxiety symptoms with peripheral artery disease treatment strategies and health status outcomes.
Odu T, Romain G, Scierka L, Cleman J, Callegari S, Jacque F, Mena-Hurtado C, Smolderen K. Interaction of anxiety symptoms with peripheral artery disease treatment strategies and health status outcomes. Vascular Medicine 2025, 1358863x241306406. PMID: 39760470, DOI: 10.1177/1358863x241306406.Peer-Reviewed Original ResearchPilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease
Kim T, Brahmandam A, Alameddine D, Forman R, Hardik A, Fucito L, Mena-Hurtado C, Guzman R, Chaar C. Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease. JVS-Vascular Insights 2025, 3: 100174. DOI: 10.1016/j.jvsvi.2024.100174.Peer-Reviewed Original ResearchSmoking cessation ratesSmoking cessation programSmoking cessationCessation programsCessation ratesQuit smokingTeachable momentInpatient smoking cessation interventionsPatient-Reported Outcomes Measurement Information System questionnairesFree nicotine replacement therapyPilot studySmoking cessation counselingSmoking cessation interventionsProvider follow-upCarbon monoxide breath testNicotine replacement therapyCare of patientsQuality of lifeCessation counselingCessation interventionsInpatient strategiesVascular surgeryMental healthStop smokingCounseling sessions
2024
Chronic Venous Insufficiency and Management
Attaran R, Babapour G, Mena-Hurtado C, Ochoa Chaar C. Chronic Venous Insufficiency and Management. Interventional Cardiology Clinics 2024, 14: 283-296. PMID: 40049854, DOI: 10.1016/j.iccl.2024.11.013.Peer-Reviewed Original ResearchConceptsVenous insufficiencyHistory of deep vein thrombosisVaricose veinsPositive family historyDeep vein thrombosisIncompetent superficial veinsChronic venous insufficiencyChronic venous diseaseElimination of varicose veinsCatheter-based techniquesVein recanalizationAssociated with poor qualityVenous obstructionVein thrombosisPharmacological therapyFamily historyVenous diseaseRisk factorsLeg discomfortFemale genderSuperficial veinsLeg ulcersProlonged standingInsufficiencyVeinNew Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease. Journal Of Nuclear Cardiology 2024, 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.Peer-Reviewed Original ResearchPeripheral arterial diseaseDiagnostic modalitiesRisk stratificationArtery diseaseEarly diagnosisImprove risk stratificationAssociated with higher ratesLower extremity peripheral arterial diseaseEvaluation of therapyClinically relevant areasPreclinical modelsObstructive atherosclerotic diseaseClinical studiesArtery stenosisMicrovascular diseasePreprocedural assessmentPeripheral vasculaturePET imagingAtherosclerotic diseaseNuclear cardiologyTherapeutic interventionsClinical diseaseDiseaseComplex physiologyPerfusionLack of diversity in patients undergoing carotid artery stenting: Implications for the Distressed Community Index
Pajarillo C, Romain G, Cleman J, Scierka L, Grubman S, Schenck C, Kluger J, Smolderen K, Mena-Hurtado C. Lack of diversity in patients undergoing carotid artery stenting: Implications for the Distressed Community Index. Vascular Medicine 2024, 30: 27-37. PMID: 39526556, DOI: 10.1177/1358863x241292545.Peer-Reviewed Original ResearchDistressed Communities IndexCommunity distressDistress groupCarotid artery stentingDistressed Communities Index scoreHierarchical Cox regressionCumulative incidence function curvesSocial determinantsNon-Hispanic/LatinoStroke incidenceAccess barriersFine-Gray modelArtery stentingDistressKaplan-Meier survival curvesVascular Quality Initiative databaseZip-codeFine-GrayMortality incidenceCox regressionAssociationAnalyzed patientsNo significant differenceMortalityLack of diversity
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