Featured Publications
Antiplatelet regimens following carotid artery revascularization
Lee M, Ahmed ZV, Huang J, Brice A, Arham A, Castro-Dominguez Y, Aboian E, Nagpal S, Smolderen KG, Mena-Hurtado C. Antiplatelet regimens following carotid artery revascularization. American Heart Journal 2022, 253: 48-52. PMID: 35863439, DOI: 10.1016/j.ahj.2022.07.004.Peer-Reviewed Original ResearchConceptsDual antiplatelet therapySingle antiplatelet therapyCarotid artery stentingCarotid endarterectomyAntiplatelet therapyReal-world clinical practiceCarotid artery revascularizationLow adherence ratesArtery revascularizationArtery stentingAdherence ratesClinical practicePatientsTherapyEngland dataHigh percentageRevascularizationAntiplateletEndarterectomyStenting
2023
The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia.
Bager L, Petersen J, Havers-Borgersen E, Resch T, Smolderen K, Mena-Hurtado C, Eiberg J, Køber L, Fosbøl E. The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia. European Journal Of Preventive Cardiology 2023, 30: 1092-1100. PMID: 36708037, DOI: 10.1093/eurjpc/zwad022.Peer-Reviewed Original ResearchConceptsEvidence-based medical therapyARB/ACEILimb-threatening ischaemiaMyocardial infarctionMedical therapyHistory of MIHigh-risk patientsFirst-time hospitalizationUnadjusted odds ratioYears of ageMore comorbiditiesPatients 40Hazard ratioDanish registriesOverall mortalityAdjusted analysisAdverse prognosisOdds ratioPractice patternsPatientsMortality rateACEIIschaemiaTherapyMortality
2022
Escalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization
Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Chaar C. Escalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Journal Of Vascular Surgery 2022, 75: e281. DOI: 10.1016/j.jvs.2022.03.640.Peer-Reviewed Original ResearchRATES OF GUIDELINE DIRECTED MEDICAL THERAPY IN PATIENTS WITH CRITICAL LIMB ISCHEMIA UNDERGOING MAJOR AMPUTATION: INSIGHTS FROM THE NATIONAL CERNER HEALTH FACTS ELECTRONIC HEALTH RECORD DATABASE
Provance J, Spertus J, Hoffman M, Jones P, Bunte M, Vogel T, Mena-Hurtado C, Smolderen K. RATES OF GUIDELINE DIRECTED MEDICAL THERAPY IN PATIENTS WITH CRITICAL LIMB ISCHEMIA UNDERGOING MAJOR AMPUTATION: INSIGHTS FROM THE NATIONAL CERNER HEALTH FACTS ELECTRONIC HEALTH RECORD DATABASE. Journal Of The American College Of Cardiology 2022, 79: 1771. DOI: 10.1016/s0735-1097(22)02762-0.Peer-Reviewed Original Research
2021
Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry
Scierka LE, Jelani QU, Smolderen KG, Gosch K, Spertus JA, Mena-Hurtado C, Jones P, Dreyer RP. Patient representativeness of a peripheral artery disease cohort in a randomized control trial versus a real-world cohort: The CLEVER trial versus the PORTRAIT registry. Contemporary Clinical Trials 2021, 112: 106624. PMID: 34793986, DOI: 10.1016/j.cct.2021.106624.Peer-Reviewed Original ResearchConceptsOptimal medical therapyPeripheral artery diseasePatient characteristicsBaseline patient characteristicsPAD cohortPAD populationPORTRAIT registryExercise therapyPAD patientsPAD symptomsArtery diseaseFinal cohortMedical therapyProspective studyBurdensome diseaseControl trialHealth statusPatientsTherapyCohortCLEVER studyDiseaseMulticenterRevascularizationRCTsReal-world antithrombotic treatment variability in patients undergoing peripheral vascular intervention: Insights from the VQI registry
Lee M, Ahmed ZV, Huang J, Jelani QU, Aboian E, Peri-Okonny PA, Smolderen KG, Mena-Hurtado C. Real-world antithrombotic treatment variability in patients undergoing peripheral vascular intervention: Insights from the VQI registry. American Heart Journal 2021, 244: 31-35. PMID: 34688650, DOI: 10.1016/j.ahj.2021.10.186.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsDual antiplatelet therapySingle antiplatelet therapyAntiplatelet therapyVascular interventionsOptimal medical therapyNew trial dataAntithrombotic prescriptionMedical therapyPrescription ratesProvider factorsVQI registryTrial dataTherapyHealth systemPatientsTreatment variabilityPractice levelInterventionHigh levelsRegistryPhysiciansLack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia
Llanos-Chea F, Jelani QU, Trejo-Paredes C, Curtis JP, Parzynski CS, Huang J, Faridi KF, Turner J, Smolderen KG, Mena-Hurtado C. Lack of Guideline-Directed Medical Therapy in Patients Undergoing Endovascular Procedures for Critical Limb Ischemia. Journal Of The American College Of Cardiology 2021, 77: 1374-1375. PMID: 33706882, DOI: 10.1016/j.jacc.2020.12.063.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCohort StudiesEndovascular ProceduresFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIschemiaMaleMiddle AgedPeripheral Arterial DiseasePlatelet Aggregation Inhibitors
2020
Adherence to Guideline-Recommended Therapy Including Supervised Exercise Therapy Referral Across Peripheral Artery Disease Specialty Clinics: Insights From the International PORTRAIT Registry
Saxon J, Safley D, Mena-Hurtado C, Heyligers J, Fitridge R, Shishehbor M. Adherence to Guideline-Recommended Therapy Including Supervised Exercise Therapy Referral Across Peripheral Artery Disease Specialty Clinics: Insights From the International PORTRAIT Registry. Journal Of Vascular Surgery 2020, 71: 1813-1814. DOI: 10.1016/j.jvs.2020.02.007.Peer-Reviewed Original ResearchAdherence to Guideline‐Recommended Therapy—Including Supervised Exercise Therapy Referral—Across Peripheral Artery Disease Specialty Clinics: Insights From the International PORTRAIT Registry
Saxon JT, Safley DM, Mena‐Hurtado C, Heyligers J, Fitridge R, Shishehbor M, Spertus JA, Gosch K, Patel MR, Smolderen KG. Adherence to Guideline‐Recommended Therapy—Including Supervised Exercise Therapy Referral—Across Peripheral Artery Disease Specialty Clinics: Insights From the International PORTRAIT Registry. Journal Of The American Heart Association 2020, 9: e012541. PMID: 31973609, PMCID: PMC7033887, DOI: 10.1161/jaha.119.012541.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmbulatory Care FacilitiesAustraliaCardiovascular AgentsExercise TherapyFemaleGuideline AdherenceHealthcare DisparitiesHumansMaleMiddle AgedNetherlandsPeripheral Arterial DiseasePractice Guidelines as TopicPractice Patterns, Physicians'Prospective StudiesQuality Indicators, Health CareReferral and ConsultationRegistriesUnited StatesConceptsSupervised exercise therapyPeripheral artery diseaseGuideline-recommended therapiesMedian odds ratioPORTRAIT registryAntiplatelet medicationsPAD symptomsOdds ratioSpecialty clinicSpecialty care facilityEvidence-based careCessation counselingExercise therapyCurrent smokersArtery diseaseCare facilitiesPatientsTherapy/counselingUS sitesReferralTherapyStatinsProcedural databaseQuality measuresMedications
2019
Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia
Haghighat L, Ionescu CN, Regan CJ, Altin SE, Attaran RR, Mena-Hurtado CI. Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia. Vascular And Endovascular Surgery 2019, 53: 316-324. PMID: 30808262, DOI: 10.1177/1538574419831489.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaLimb ischemiaDevelopment of CLIMolecular therapyPoor surgical candidatesImpairment of angiogenesisSurgical candidatesMicrovascular changesNovel imaging modalityTreatment optionsMorbid diseaseTranslational medicine studiesTherapyMedicine studiesImaging modalitiesIschemiaDiseasePatientsPathophysiologyArteriogenesisImpairmentTrialsAntiplatelet therapy for tibial balloon angioplasty: A clinical perspective
Ionescu CN, Altin SE, Mena-Hurtado C. Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective. SAGE Open Medicine 2019, 7: 2050312119854579. PMID: 31210934, PMCID: PMC6545680, DOI: 10.1177/2050312119854579.Peer-Reviewed Original ResearchTibial balloon angioplastyCritical limb ischaemiaBalloon angioplastyAntiplatelet therapyLimb ischaemiaCritical limb ischaemia patientsNumber of patientsMultiple comorbiditiesPreclinical dataAngioplasty techniquesTherapeutic approachesHigh riskPost interventionAngioplastyClinical perspectiveTherapyIschaemiaPatientsShort durationComorbiditiesTrialsImportant role
2016
Carotid artery stenting versus carotid endarterectomy
Nanna MG, Gomes P, Njoh RF, Ward C, Attaran RR, Mena C. Carotid artery stenting versus carotid endarterectomy. Postgraduate Medical Journal 2016, 92: 532-539. PMID: 27317752, DOI: 10.1136/postgradmedj-2015-133689.Peer-Reviewed Original ResearchConceptsCarotid endarterectomyCarotid artery stentingCarotid artery stenosisArtery stentingMedical therapyArtery stenosisCarotid stenosisTreatment optionsSurgical techniqueTreatment strategiesCarotid arteryMajor causeEndarterectomyStenosisStrokeMorbidityStentingArterySignificant contributorOptionsTherapyMortalityTrials
2015
Endovascular Treatment of Below the Knee Arteries
Ward C, Gamberdella J, Mena-Hurtado C. Endovascular Treatment of Below the Knee Arteries. 2015, 3195-3203. DOI: 10.1007/978-3-642-37078-6_192.Peer-Reviewed Original ResearchPatient-specific challengesBTK interventionKnee revascularizationPeriprocedural medicationsArterial revascularizationEndovascular revascularizationKnee arteriesEndovascular treatmentBTK arteriesAngiosome conceptWidespread therapyEndovascular specialistsAnatomical considerationsRevascularizationPatientsArteryAccess approachMedicationsTherapy
2014
Endovascular Treatment of Below-the-Knee Arteries
Ward C, Gamberdella J, Mena-Hurtado C. Endovascular Treatment of Below-the-Knee Arteries. 2014, 1-11. DOI: 10.1007/978-3-642-37393-0_192-2.Peer-Reviewed Original ResearchPatient-specific challengesBTK interventionKnee revascularizationPeriprocedural medicationsArterial revascularizationEndovascular revascularizationKnee arteriesEndovascular treatmentBTK arteriesAngiosome conceptWidespread therapyEndovascular specialistsAnatomical considerationsRevascularizationPatientsArteryAccess approachMedicationsTherapyManagement of Atherosclerotic Aortoiliac Occlusive Disease
Bujak M, Gamberdella J, Mena C. Management of Atherosclerotic Aortoiliac Occlusive Disease. Interventional Cardiology Clinics 2014, 3: 531-543. PMID: 28582078, DOI: 10.1016/j.iccl.2014.06.001.Peer-Reviewed Original ResearchAortoiliac occlusive diseaseOcclusive diseaseAtherosclerotic aortoiliac occlusive diseaseNew revascularization techniquesRisk factor modificationClassic risk factorsGold standard therapyInvasive endovascular techniquesCardiovascular eventsRevascularization techniquesStandard therapyAtherosclerotic diseaseEndovascular techniquesSmoking cessationSurgical interventionSymptom improvementFactor modificationRisk factorsDiseaseTherapyPreventionSecondary goalHypertensionHyperlipidemiaSmokingManagement of Symptomatic Carotid Disease in 2014
Litsky J, Stilp E, Njoh R, Mena-Hurtado C. Management of Symptomatic Carotid Disease in 2014. Current Cardiology Reports 2014, 16: 462. PMID: 24464307, DOI: 10.1007/s11886-013-0462-3.Peer-Reviewed Original ResearchConceptsSymptomatic carotid stenosisCarotid artery stentingCarotid endarterectomyCarotid stenosisMedical therapyHigh-grade symptomatic carotid stenosisExtracranial carotid artery stenosisPreventive medical therapyClass I recommendationSymptomatic carotid diseaseCarotid artery stenosisCause of deathRetinal symptomsStroke preventionArtery stentingI recommendationLandmark trialsPerioperative eventsArtery stenosisCarotid diseaseSymptomatic lesionsNoninvasive evaluationStenosisTherapyModern management
2013
Upper Extremity Interventions
Huynh T, Mena-Hurtado C. Upper Extremity Interventions. 2013, 371-379. DOI: 10.1007/978-1-4471-4528-8_29.Peer-Reviewed Original ResearchUpper extremity interventionsSubclavian arterySubclavian artery lesionsExtracranial cerebrovascular diseaseLeft subclavian arteryAtherosclerotic occlusive diseasePrinciple etiologySubclavian stenosisArtery lesionsOcclusive diseaseEndovascular therapyCerebrovascular diseaseEndovascular proceduresTraditional surgeryProximal segmentSafe alternativeArteryLesionsDiseaseInterventionStenosisSurgeryTherapyEtiologyInnominate